A5091819241- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Food Allergy and Anaphylaxis Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Antibiotics Pharmacokinetics and Efficacy
- Adenosine and Purinergic Signaling
- Renal Diseases and Glomerulopathies
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune and Inflammatory Disorders Research
- Blood disorders and treatments
- Vascular Malformations and Hemangiomas
- Salivary Gland Disorders and Functions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Dermatological and COVID-19 studies
- Cerebrovascular and genetic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
Hôpital du Valais
2023-2025
University Hospital of Lausanne
2019-2025
Hôpital de Sion
2025
University of Lausanne
2020-2024
Hôpital de l'enfance
2018-2021
Hôpital Orthopédique de la Suisse Romande
2019-2021
Despite newer treatments with immunosuppressive agents, there still exists a considerable morbidity and mortality risk among patients anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Since 1994 the European Vasculitis Society (EUVAS) has aimed for an improved outcome AAV, conducting several prospective randomized controlled trials (RCTs). The aim present study was to further evaluate long-term survival of AAV included in seven RCTs conducted by EUVAS as well identify...
Eosinophilic granulomatosis with polyangiitis (EGPA) is often associated glucocorticoid-dependent asthma and/or ear, nose and throat (ENT) manifestations. When immunosuppressants mepolizumab are ineffective, dupilumab could be an option. We describe the safety efficacy of off-label use in relapsing refractory EGPA.We conducted observational multicentre study EGPA patients treated dupilumab. Complete response was defined by Birmingham Vasculitis Activity Score (BVAS)=0 prednisone dose ≤4...
Kidney involvement is common in anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) and the prognosis determined by severity of kidney damage. This study focused on long-term outcomes, defining possible risk factors comparing performance three different histological classifications to predict outcomes for patients with AAV.
<h3>Background:</h3> Aromatase inhibitor (AI) therapy in women with estrogen receptor-positive (ER+) breast cancer (BC) causes accelerated bone loss and increased risk of osteoporosis fractures as side effects. Denosumab (i.e. 60 mg twice a year) is viable against resorption, but the short-term monitoring mineral density (BMD) change time still an unmet clinical need, since current techniques (including dual-energy X-ray absorptiometry, DXA) require 1-2 years between two consecutive...
Background: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries classically associated with cranial manifestations ischaemia, such as headaches (notably temporal region), jaw claudication visual symptoms that can lead to blindness. Extracranial are less frequently reported related involvement thoracic abdominal aorta its main branches. Classic diagnostic tools (such artery ultrasonography...
Background: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries classically associated with cranial manifestations ischaemia, such as headaches (notably temporal region), jaw claudication visual symptoms that can lead to blindness. Extracranial are less frequently reported related involvement thoracic abdominal aorta its main branches. Classic diagnostic tools (such artery ultrasonography...
Following the results of MANDARA trial, this real-life study aimed at comparing effectiveness and safety profile mepolizumab versus benralizumab in a European EGPA cohort. We conducted retrospective observational comparative including patients, who received or asthma dose. Patients were matched 1:1 by sex, age, BVAS oral corticosteroid (OCS) dosage treatment initiation (T0). Complete response (CR) partial (PR), disease activity, OCS, pulmonary parameters, eosinophil count, relapses, outcomes...
Dear editor, The rapidly expanding coronavirus disease 2019 (COVID-19) is a global health challenge and source of anxiety amplified by the constant news stream. The mortality rate from COVID-19 difficult to establish given heterogeneity reports confounding factors such as difference in healthcare systems around world. occurrence severe acute respiratory distress syndrome (ARDS) are increased elderly patients with underlying conditions cardiovascular chronic conditions. To date, neither...
Abstract Background Up to 20% of patients with moderate severe Graves' orbitopathy (GO) do not respond high‐dose glucocorticoids (GC). A few studies, including a randomized trial, have demonstrated the efficacy interleukin‐6 (IL‐6) blockade tocilizumab (TCZ) in GC‐refractory GO. However, data on predictors response TCZ and long‐term outcomes are lacking. Methods Observational single‐center study ten consecutive treated for GO, between 2016 2020. Median (interquartile range) follow‐up was 24...
Beta-lactam allergy is a common problem in everyday medical practice and recognized as major public health issue. Carrying this label frequently leads to the avoidance of all beta-lactam antibiotics, favoring use other less preferred classes that are more expensive associated with side effects increased antimicrobial resistance. Therefore, delabeling part stewardship programs. Herein, we retrospectively examined clinical records 576 patients who were referred our center for antibiotics...
Most hospitals use electronic health records (EHR) to warn care professionals of drug hypersensitivity (DH) and other allergies. Indiscriminate recording patient self-reported allergies may bloat the alert system, leading unjustified avoidances increases in costs. The aim our study was analyze hypersensitivities documented EHR patients at Lausanne University Hospital (CHUV).
During one of the worst global health crises, millions people were vaccinated against SARS-CoV-2. In rare cases, new onset systemic inflammatory diseases reported with temporal coincidence to vaccination. We describe a case severe Eosinophilic Granulomatosis Polyangiitis (EGPA) in young asthmatic woman, occurring after second dose mRNA-1273 vaccine. She presented multisystem EGPA cardiac and central nervous system involvement, complicated by secondary immune thrombocytopenia (ITP). review...
Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can involve smaller vessels. The clinical presentation heterogeneous characterized by significant number patients exhibiting general symptoms including asthenia, fever, unintended weight loss. Although PAN virtually any organ, preferentially the skin, nervous system, gastrointestinal tract....
Background: Beta-lactam antibiotics are the most frequent drug family to cause allergic reactions. Herein, we examined frequency of confirmed allergies beta-lactam, as well sensitivity and negative predictive value (NPV) skin testing in an adult population referred a university allergy clinic Switzerland. Methods: This is retrospective analysis clinical records patients who were investigated for label beta-lactam (penicillin, cephalosporin or carbapenem) between January 1 2011 December 31...
Background: Following the results of MANDARA trial, this real-life study aimed at comparing effectiveness and safety profile mepolizumab versus benralizumab in a European EGPA cohort. Methods: We conducted retrospective observational comparative including patients, who received or asthma dose. Patients were matched 1:1 by sex, age, BVAS oral corticosteroid (OCS) dosage treatment initiation (T0). Complete response (CR) partial (PR), disease activity, OCS, pulmonary parameters, eosinophil...
Adenosine deaminase 2 deficiency (DADA2) is a genetic auto- inflammatory disease that most often presents in childhood, but can also have late onset adulthood. It characterized by vasculitis, mainly of the skin and nervous system form stroke, associated to immunodeficiency cytopenias. The diagnosis made measuring adenosine (ADA2) enzymatic activity confirming presence mutations ADA2 gene testing. treatment choice for phenotype early administration anti-TNFa avoid risk major neurological...
Abstract BACKGROUND AND AIMS Kidney involvement is common in ANCA-associated vasculitis (AAV) and prognosis largely determined by the severity of kidney damage at diagnosis response to treatment. Rapidly progressive glomerulonephritis most severe clinical manifestation AAV. Current therapy with immunosuppressive glucocorticoid treatment plays a crucial role rescue function, but rate patients reaching end-stage renal disease (ESRD) remains high. The aim study determine predictive factors...