A5087870399- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Heart Failure Treatment and Management
- Estrogen and related hormone effects
- Ovarian function and disorders
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Potassium and Related Disorders
- Radioactive Decay and Measurement Techniques
- Hormonal and reproductive studies
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Cytokine Signaling Pathways and Interactions
- Pluripotent Stem Cells Research
- Atherosclerosis and Cardiovascular Diseases
Einstein Medical Center Philadelphia
2025
Johns Hopkins University
2023-2024
Johns Hopkins Medicine
2023
University of Wisconsin–Madison
2018-2022
Central University of Venezuela
2014-2017
"HSR25-162: Long-term Outcomes in Patients With Tumor Lysis Syndrome and Comorbid Gout: A Propensity-Matched Study From the Global Federated Health Research Network" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Objectives Emerging evidence has shown a role for tumor antigen-specific regulation in cancer. Identifying individuals with pre-existing regulatory responses may be key to understand those who are more likely respond Programmed Death-1 (PD-1) or PD-1 Ligand 1 (PD-L1) checkpoint blockade. We hypothesized that functional assay could identify the of PD-1/PD-L1 interactions on tumor-specific immune cells peripheral blood patients advanced non-small-cell lung cancer (NSCLC). Methods performed...
Individuals harbor preexisting HLA-DR/DQ-restricted responses to collagen type V (ColV) mediated by Th17 cells under Treg control, both specific peptides that bind inherited HLA class II antigens. Yet after transplant, the donor-DR somehow influences graft outcome. We hypothesized that, long a lung or heart allograft, particular HLA-DR of mismatched transplant donor transforms specificity "anti-self" response. This could explain why, over term, certain DRs be more immunogenic than others.We...
The aim of this study was to investigate the impact estrogen and progesterone analog supplementation on development autoimmune conditions.
Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise preclinical studies and case reports. We hypothesized that of IL1RAP (IL-1 receptor accessory protein), a shared subunit the IL-1, IL-33, IL-36 receptors, could be more efficient than IL-1 alone.
175 Background: The success of PD-1/PD-L1 inhibition is clearly dependent on optimal patient selection. Developing validated biomarkers that identify patients with an increased probability response to these antibodies remains a challenge. DTH responses are standard method evaluate cellular immune in animal and human immunotherapy trials. trans-vivo delayed-type hypersensitivity (tvDTH) methodology, using the SCID mouse footpad swelling PBMC (peripheral blood mononuclear cells) + antigen...
Abstract IL-1, IL-33 and IL-36 have complementary pro-inflammatory roles during the immune response promoting autoimmune inflammatory diseases, such as myocarditis. Therapeutic blockers targeting IL-1 pathway previously been developed. However, we hypothesized that blockade of shared co-receptor these three pathways, receptor accessory protein (IL1RAP), would exhibit a more potent broader anti-inflammatory profile. To investigate this hypothesis, induced coxsackievirus B3 (CVB3)-mediated or...
In Spanish colonial California, the folk-hero "Zorro" left his mark on by a sword- slashed "Z".In transplant recipients, rare Tregs also leave their conventional T & B LC targets. This is caused Ag-specific CD4 that release IL35-coated exosomes, “cross-dressing” (xD) targets with IL35. Hypothesis We wished to test 3 hypotheses related this finding: 1) just as MHC+ exosome “passenger” DC greatly amplifies alloactivation xD of host DC, IL35 suppression passenger amplified cells; 2) monitoring...
IL-1, IL-33 and IL-36 have complementary, pro-inflammatory roles during the immune response that promote autoimmune diseases, particularly myocarditis. While antibodies neutralize circulating cytokines exist, we hypothesized blockade of their shared co-receptor, IL-1 receptor accessory protein (IL1RAP), would exhibit a more potent broader anti-inflammatory profile. The CAN10 antibody blocks IL1RAP is currently under development for treating severe inflammatory diseases. To investigate if an...