Seawater-strength salt stress of the ice plant (Mesembryanthemum crystallinum) initially results in wilting, but full turgor is restored within approximately 2 days. We are interested a mechanistic explanation for this behavior and, as requisite in-depth biochemical studies, have begun to analyze gene expression changes roots coincident with onset stress. cDNAs that suggested mRNA amount under were found; their deduced amino acid sequences share homologies proteins Mip (major intrinsic...

The antipsychotic efficacy of aripiprazole is not generally associated with extrapyramidal symptoms, cardiovascular effects, sedation or elevations in serum prolactin that characterize typical atypical antipsychotics. aim this study was to clarify the mechanism action underlies its favourable clinical profiles. preclinical and side-effect profiles were evaluated usingseveral pharmaco-behavioural test systems mice rats, both vivo ex vivo, compared those other conventional Each antipsychotics...

Kisspeptin, a peptide encoded by the Kiss1 gene, has been considered as potential candidate for factor triggering onset of puberty, and its expression in hypothalamus was found to increase during peripubertal period rodent models. The present study aimed clarify oestrogenic regulation changes mRNA anteroventral periventricular nucleus (AVPV) hypothalamic arcuate (ARC), determine which population kisspeptin neurones shows change parallel that luteinising hormone (LH) pulses at period....

The present study was conducted to determine the morphological and functional interaction between kisspeptin gonadotrophin-releasing hormone (GnRH) neuronal elements at median eminence in female rats clarify a possibility that directly stimulates GnRH release nerve end. A dual immunoelectron microscopic of showed kisspeptin-immunoreactive element abutted GnRH-immunoreactive element, although no obvious synaptic structure found neurones eminence. current retrograde tracing with FluoroGold...

Deduced amino acid sequences encoded by the cDNAs related to MIP gene family from Nicotiana excelsior were characterized. Phylogenetic characterization of products corresponding genes named NeMip1, NeMip2, and NeMip3 strongly suggested that they are water channel proteins localized in plasma membrane. Organ specificity expression was examined leaves, roots, reproductive organs. NeMip1 expressed roots organs; however, it hardly detectable leaves. Two other genes, NeMip2 NeMip3, all organs...

Follicular development and ovulation are strongly suppressed during lactation in mammals via a profound suppression of gonadotrophin secretion. The present study aimed to examine the role oestrogen feedback action suppressing luteinising hormone (LH) secretion hypothalamic kisspeptin expression latter half lactation. Plasma LH concentrations kept at low levels throughout lactating period intact oestrogen-replaced ovariectomised (OVX) rats, whereas plasma gradually elevated from day 10...

This study aimed to describe real-world treatment patterns and medication adherence among patients with bipolar disorder (BD) in Japan.Adult a BD diagnosis were identified between July 2013 February 2018, using an employment-based health insurance claims database from the JMDC Inc. Treatment of target drugs (mood stabilizers, antipsychotics) (measured by proportion days covered [PDC]) assessed during first- through third-year follow-up. Adherence was also for patient subgroups.The analyzed...

The promoter region of the MipB gene encoding an aquaporin from Mesembryanthemum crystallinum was isolated and used in a transcriptional fusion to control uidA expression tobacco. sequence determined for 2 kb upstream translation initiation site. Three start sites were utilized with approximately equal frequency, located 176, 170, 161 bases, respectively, As judged by analysis GUS expression, retains its specificity transgenic In germinating seedlings, all cells showed different intensities...

Vasopressin V(1b) receptor is specifically expressed in the pituitary and mediates adrenocorticotropin release, thereby regulating stress responses via its corticotropin releasing factor-like action. In present study we examined catecholamine release response to two types of mice lacking gene (V(1b)R(-/-) mice) vs. wild-type mice. There were no significant differences basal plasma levels catecholamines between genotypes. induced by forced swimming, norepinephrine (NE), but not epinephrine...

Persistence with antipsychotic treatment is critical in managing patients schizophrenia. To evaluate whether aripiprazole long-acting injection (aripiprazole once-monthly, AOM) can contribute to longer persistence compared daily orally administered (OA) real-world clinical settings Japan, schizophrenia was between treated AOM and those OA, using a claims database compiled by JMDC Inc., Tokyo, Japan. Data of who newly initiated or OA May 2015 November 2017 were analyzed. The Cox proportional...

Abstract The rate of medication persistence was examined in patients with schizophrenia or schizoaffective disorder during switching from previously administered antipsychotics to brexpiprazole, a new dopamine D 2 receptor partial agonist. A multicenter, single‐arm, open‐label 24‐week interventional study conducted, consisting two 12‐week consecutive periods: an initial switch (by plateau cross‐titration) the subsequent period, followed by second maintenance period. Prior were olanzapine...

Sigma and 5-HT(1A) receptor stimulation can increase acetylcholine (ACh) release in the brain. Because ACh facilitates learning memory, we evaluated degree to which OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethane sulfonate), a novel sigma agonist, augment improve impairments rats due cholinergic- or age-related deficits. Single oral administration of improved scopolamine-induced passive-avoidance task memory impairment Morris...

Treatment continuation is essential for relapse prevention in patients with schizophrenia. The aim of this exploratory study was to compare the time treatment discontinuation between schizophrenia prescribed brexpiprazole (BRX group) and those other atypical antipsychotics (OAA clinical settings Japan using health insurance claims data.De-identified data working individuals aged < 75 years their dependents were assessed from April 2017 May 2020 a nationwide database. Cox proportional hazards...

The reasons for the presence of a multitude plasma membrane-localized water channels (PIP aquaporins) in plants may be functional differences (or other solute) transport, or developmental, environmental tissue- specific regulation expression. We compared tissueand cell-specific expression McMipA, an abundantly expressed PIP from common ice plant (Mesembryanthemum crystallinum), with that previously characterized McMipB [Yamada et al. (1997) Plant Cell Physiol. 38: 1326]. activity 2.2 kb DNA...

Abstract Objectives To determine the long‐term safety of switching to brexpiprazole from aripiprazole or non‐aripiprazole dopamine antagonists. Methods Post‐hoc analysis 56‐week study Japanese outpatients with schizophrenia switched 2 mg/day over 4‐week period further titration (1–4 mg/day) allowed during 52‐week, open‐label period. Major assessment items: total/low‐density lipoprotein (LDL)‐/high‐density (HDL)‐cholesterol, triglycerides, blood glucose, body weight and prolactin. Secondary...

We have previously shown that 48-h fasting profoundly suppresses pulsatile LH secretion in female rats the presence of estrogen, and paraventricular nucleus (PVN) is an estrogen action site mediating this inhibition. The present study determined whether male a testosterone-dependent manner, PVN involved fasting-induced changes release. Mean concentrations baseline levels pulses were significantly reduced by castrated males implanted with various length (6, 12, 24 mm) subcutaneous...

This study was performed to assess the long-term efficacy, safety, and tolerability of brexpiprazole in elderly Japanese patients with schizophrenia.This is a post hoc analysis previous open-label conducted over 56 weeks which consisted two consecutive phases: 4-week switching period 52-week period. Mean change Positive Negative Syndrome Scale (PANSS) total score, response rates, number incidence treatment-emergent adverse events (TEAEs), other safety parameters were analyzed using...

Abstract Background The main objective of this study was to examine the burden schizophrenia, depression, Alzheimer’s disease/dementia, and stroke on caregivers non-caregivers in Japan. This also aimed provide a comparative landscape caregiving for each disorder. Methods Japan National Health Wellness Survey database, 2016 2018 used study. Health-related quality life (HRQoL), work productivity, health care utilization were assessed using self-administered, Internet-based questionnaire....