A5034335495- Helicobacter pylori-related gastroenterology studies
- Human-Automation Interaction and Safety
- RNA modifications and cancer
- Diabetes Management and Research
- Genetic factors in colorectal cancer
- Diabetes Treatment and Management
- Pharmacological Receptor Mechanisms and Effects
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Risk and Safety Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Occupational Health and Safety Research
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Gastric Cancer Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Long-Term Effects of COVID-19
Tokyo Medical University
2015-2025
Osaka University
1979-2025
Konan Kosei Hospital
2024
Tokyo Medical University Hospital
2001-2023
Kobe University
2017-2023
Tokyo Medical University Hachioji Medical Center
2023
NTT (Japan)
2009-2023
Suzuki (Japan)
2021-2022
Weatherford College
2022
California Maritime Academy
2021
Background— Microvascular renal and retinal diseases are common major complications of type 2 diabetes mellitus. The relation between plasma lipids microvascular disease is not well established. Methods Results— case subjects were 2535 patients with mellitus an average duration 14 years, 1891 whom had kidney 1218 retinopathy. matched for duration, age, sex, low-density lipoprotein cholesterol to 3683 control who did have or study was conducted in 24 sites 13 countries. primary analysis...
The antipsychotic efficacy of aripiprazole is not generally associated with extrapyramidal symptoms, cardiovascular effects, sedation or elevations in serum prolactin that characterize typical atypical antipsychotics. aim this study was to clarify the mechanism action underlies its favourable clinical profiles. preclinical and side-effect profiles were evaluated usingseveral pharmaco-behavioural test systems mice rats, both vivo ex vivo, compared those other conventional Each antipsychotics...
Purpose: To clarify the prevalence and symptomatic characteristics of sleep disturbance/insomnia among type-2 diabetes mellitus (DM) Japanese patients. Methods: A cross-sectional survey patients with disorder was conducted. Participants consisted 622 DM (mean 56.1±9.56 years) sex- age-matched controls. Participants’ scores in version Pittsburgh Sleep Quality Index (PSQI-J), 12-item Center for Epidemiologic Studies Depression Scale (CES-D), Medical Outcomes Study 8-item Short Form Health...
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that causes degeneration of both upper and lower motor neurons. TAR DNA‐binding protein 43 kDa (TDP‐43) mislocalized in the neurons patients with ALS. TDP‐43 regulates RNA metabolism, including alternative splicing. Although dysregulation splicing by supposed to have key role ALS pathology, nature aberrant tissues has not been well studied. Aim To screen for alterations find those linked pathology. Methods...
ABSTRACT Objective Waist circumference measurement is commonly used as a method for predicting the visceral fat area. However, waist difficult to measure, and there large margin of error between measurements. Visceral adipose tissue that accumulates in abdominal cavity, when it excess, computed tomography reveals prominent protrusion anterior–posterior diameter abdomen coronal section at umbilicus level. Individuals with obesity often show forward protrusions. This study aimed verify whether...
To develop a novel antidepressant drug with central nervous system-stimulating activity, we prepared series of 1-[omega-(4-substituted phenyl-1-piperazinyl)alkyl]-3, 4-dihydro-2(1H)-quinolinone derivatives and examined their activities by effects at 30 100 mg/kg po on the sleeping time mice anesthetized halothane required for recovery from coma induced in cerebral concussion. We binding affinities sigma receptors evaluating ability to inhibit [(3)H]-1,3-di(o-tolyl)guanidine ([(3)H]DTG) rat...
Mental workload (MWL) is one of core elements human factor construct reflecting arousal level, and its optimisation crucial to maintain favourable operator functional state. However, sensible, reliable, diagnostic measurement MWL essential for applications adaptive aiding system design, usability testing, seafarers' training. To develop robust measures, 10 participants voluntarily participated in a simulator-based experiment study. During this study, the carried out standard four-level...
The interfacial tension between molten iron and slag was measured by the sessile drop method with transmission X-ray technique. Oxygen in remarkably decreased surface of melt at slag-metal boundary. It suggests that oxygen dissolved acts as a active solute interface. Consequently, depended, most part, on content melt, but composition had minor effect tension.In order to clear tension, experimental results were discussed terms Δσ(=σm-σms) indicated difference constant sufrace melt. values Δσ...
This study was designed to evaluate two pen needles (PNs) with the same diameter but different lengths (4 mm and 6 mm) needle tip shapes (straight tapered) compare their effects on glycemic control, perceived pain, safety, patients' ease of use preferences, visual impression.In this prospective, open-label, controlled crossover study, 41 insulin-treated patients type 1 or 2 diabetes were randomized into either Group (the 32-gauge × 4-mm PN used during Study Period 1, then 6-mm 2) order for...
We prospectively examined the additional effects of highly purified eicosapentaenoic acid (EPA) particularly on vascular function diabetic patients with hypercholesterolemia receiving statin therapy. enrolled 28 type 2 diabetes complicated by dyslipidemia who had been treated statins for at least one year. The were randomly assigned to groups: administration alone (group S: n = 13) and addition EPA current therapy SE: 15). was administered a dose 1,800 mg/day 6 months. To evaluate function,...
The interfacial tension between molten steel and slag was measured by the sessile drop method with transmission X-ray technique. results were summarised as follows;(1) increase of oxygen content in caused remarkable decrease surface at steel-slag boundary. fact shows that dissolved acts surface-active reagent metal-slag boundary well metal-gas interface.(2) Consequently, depended most part on effect composition not so much.(3) In order to clear tension, experimental discussed values Δσ...
Despite numerous reports that have linked diabetes with cognitive impairment (CI), there are few studies attempted to clarify the morbidity of CI among elderly diabetic patients. The Mini-Mental State Examination (MMSE) was performed on 240 patients aged 65 years or older who had no diagnosis dementia. MMSE scores were 28-30 (normal range) in 151 (63%), 24-27 (suspected CI) 77 (32%), and ≤ 23 (definite 12 (5%). Eight underwent further detailed examination: final Alzheimer's disease (AD) (N =...
ABSTRACT We assessed the association of neutrophil function with glycated hemoglobin (HbA1c) levels in a Japanese general population. Participants were 809 males and females who over 20 years old living Iwaki region Aomori Prefecture located northern Japan. Lifestyle parameters (smoking, alcohol consumption, exercise habits), HbA1c such as reactive oxygen species (ROS) production capability phagocytic activity (PA) measured. ROS was measured before after stimulus to obtain basal stimulated...
Although type 2 diabetes mellitus (DM) is a risk factor for the development of dementia, underlying brain pathologies and mechanisms vary among patients. In this study, we classified patients with clinically diagnosed Alzheimer's disease (AD) associated DM into subgroups based on their amyloid tau accumulation patterns positron emission tomography (PET), analyzed differences in clinical features imaging findings between subgroups. Sixty-four probable or possible AD were using PiB (detects...
Objective For measuring serum 3,3′,5′-triiodothyronine (rT3) levels, radioimmunoassay (RIA) has traditionally been used owing to the lack of other reliable methods; however, it recently become difficult perform. Meanwhile, liquid chromatography-tandem mass spectrometry (LC-MS/MS) attracting attention as a novel alternative method in clinical chemistry. To best our knowledge, there are no studies date comparing results quantification human rT3 between LC-MS/MS and RIA. We therefore examined...