Benjamin Lazarus

ORCID: 0000-0001-7936-025X
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About
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Research Areas
  • Gastroesophageal reflux and treatments
  • Dialysis and Renal Disease Management
  • Cardiac pacing and defibrillation studies
  • Central Venous Catheters and Hemodialysis
  • Potassium and Related Disorders
  • Cardiac Arrhythmias and Treatments
  • Helicobacter pylori-related gastroenterology studies
  • Vasculitis and related conditions
  • Nephrotoxicity and Medicinal Plants
  • Drug-Induced Adverse Reactions
  • Renal Diseases and Glomerulopathies
  • Vascular Procedures and Complications
  • Diabetes Treatment and Management
  • Antibiotic Resistance in Bacteria
  • Acute Kidney Injury Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Neurological disorders and treatments
  • Chronic Kidney Disease and Diabetes
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Amoebic Infections and Treatments
  • Eicosanoids and Hypertension Pharmacology
  • ECG Monitoring and Analysis
  • Magnesium in Health and Disease
  • Facilities and Workplace Management
  • Escherichia coli research studies

Monash Health
2019-2025

Monash University
2023-2025

The University of Queensland
2014-2025

Princess Alexandra Hospital
2025

Queensland Health
2025

The George Institute for Global Health
2023-2024

UNSW Sydney
2023-2024

Monash Medical Centre
2018-2023

Austin Health
2019-2020

Johns Hopkins University
2016-2019

<h3>Importance</h3> Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about association between PPI use chronic kidney disease (CKD). <h3>Objective</h3> To quantify incident CKD in a population-based cohort. <h3>Design, Setting, Participants</h3> In total, 10 482 participants Atherosclerosis Risk Communities study with an estimated glomerular filtration rate of at least 60 mL/min/1.73...

10.1001/jamainternmed.2015.7193 article EN JAMA Internal Medicine 2016-01-11

Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy metformin. This may reflect uncertainty regarding risk of acidosis chronic disease.

10.1001/jamainternmed.2018.0292 article EN JAMA Internal Medicine 2018-06-04

ABSTRACT Aim Evaluate the area‐level incidence of kidney failure due to diabetes among Australians aged ≤ 45 years. Methods Using Australian registry and census data (2000–2022), rates prevalence (defined as commencing replacement therapy) people years were compared by geographical region. Results Incidence (per 100 000/year, 95% confidence interval) in Australia was 0.72 (0.68–0.77) 2000–2011, 1.13 (1.07–1.18) 2012–2022 (incidence rate ratio [IRR] 1.56, 1.50–1.62). Between 2012 2022, there...

10.1111/nep.70019 article EN cc-by-nc-nd Nephrology 2025-03-01

Abstract Accurate assessment of fluid status is a priority for patients with kidney failure undergoing long-term dialysis. There wide variation in current volume-related practices between dialysis units and an urgent need to develop better evidence guide practice. Clinical decisions relating volume management are implicitly based on status, there numerous different but imperfect methods assessment. Isotope-based dilutions impractical clinical use may not be gold-standard failure. Individual...

10.1681/asn.0000000724 article EN Journal of the American Society of Nephrology 2025-04-07

Millions of patients with kidney failure rely on hemodialysis (HD) central venous catheters (CVC) for their life-sustaining dialysis treatments. CVC dysfunction necessitates removal up to 20% CVCs and is an important problem failure. Thrombosis fibrin sheath formation are the most common mechanisms beyond first week after insertion. Factors such as female sex, left-sided placement prior increase risk dysfunction. Patient specific factors contribute substantially variation in number events....

10.1681/asn.0000000666 article EN Journal of the American Society of Nephrology 2025-02-20

BACKGROUND: Untreated microangiopathic hemolytic anemia in pregnancy is associated with adverse maternal and perinatal outcomes. Accurate diagnosis challenging owing to nonspecific clinical features pathologic findings. Timely initiation of appropriate management essential optimize CASE: A 26-year-old primiparous woman presented at 20 weeks gestation new-onset on a background poorly controlled type 1 diabetes. She received eculizumab for presumed atypical uremic syndrome. At 24 gestation,...

10.1097/aog.0000000000003570 article EN Obstetrics and Gynecology 2019-11-04

Key Points Replacement strategies for hemodialysis catheters with mechanical failure differed widely between services, which suggests clinical equipoise. For catheter failure, exchange did not result in more dysfunction or infection than removal and separate replacement. In Australia, infected were almost universally removed then replaced through a tunnel tract. Background Tunneled often have infectious complications that require unplanned replacement, but the optimal replacement strategy is...

10.2215/cjn.0000000000000495 article EN Clinical Journal of the American Society of Nephrology 2024-06-24

Acute interstitial nephritis (AIN) is a leading cause of acute kidney injury (AKI) in hospitalized patients, and β-lactam antibiotics are common cause.1Perazella M.A. Diagnosing drug-induced AIN the patient: challenge for clinician.Clin Nephrol. 2014; 81: 381-388Crossref PubMed Scopus (42) Google Scholar Early diagnosis β-lactam−induced essential to direct changes therapy, but it often difficult distinguish from other causes AKI, such as tubular necrosis. A biopsy gold-standard diagnostic...

10.1016/j.ekir.2020.04.008 article EN cc-by-nc-nd Kidney International Reports 2020-04-20

Since 1980, we have implanted 910 carbon tip leads from three different manufacturers. The pacing thresholds these were compared to those of standard polished platinum electrode configurations. Our major findings are that while acute voltage not significantly different, two the used in study statistically lower chronic then (p ≤ 0.01).

10.1111/j.1540-8159.1986.tb06700.x article EN Pacing and Clinical Electrophysiology 1986-11-01

This report describes some of the various techniques which may be used to demonstrate intermittent and/or incomplete fracture a pacing lead. Eleven patients treated with an R-wave-inhibited demand pacer showed signs paroxysmal arrhythmias. Intraoperative recordings ventricular electrogram presence spurious signals mimicking R-wave. These varied from patient but remained morphologically constant when given technique was in case. The most significant were picked up and recording on same

10.1111/j.1540-8159.1978.tb03466.x article EN Pacing and Clinical Electrophysiology 1978-04-01

Recent developments in cardiac pacemaker electrodes have resulted significant benefits to the group of patients as a whole. The results analysis 2,818 chronic are presented. These divided into major categories according their particularities: platinum iridium, elgiloy, carbon‐tip, anodized and granulated iridium‐platinum. All leads were ventricular position. acute threshold measurements reveal that carbon‐tipped appear most favorable overall characteristics. This will influence on long‐term...

10.1111/j.1540-8159.1988.tb06305.x article EN Pacing and Clinical Electrophysiology 1988-11-01

A controversy arose some 10 years ago over the reliability of polyurethane lead insulation. On basis one longest standing and largest databanks worldwide, authors compare cumulative survival several thousand polyurethane, standard silastic, high-performance silastic electrodes as it pertains to failure criterion described insulation degradation. With possible exception Medtronic 6972 (Medtronic, Inc.) electrode, have a 100% at 84 months, which is similar electrodes.

10.1111/j.1540-8159.1992.tb03003.x article EN Pacing and Clinical Electrophysiology 1992-11-01
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