Konstantinos Sfakianoudis

ORCID: 0000-0001-7939-5903
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About
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Research Areas
  • Reproductive Biology and Fertility
  • Ovarian function and disorders
  • Assisted Reproductive Technology and Twin Pregnancy
  • Reproductive Health and Technologies
  • Reproductive System and Pregnancy
  • Endometriosis Research and Treatment
  • Prenatal Screening and Diagnostics
  • Sexual function and dysfunction studies
  • Sperm and Testicular Function
  • Pregnancy and Medication Impact
  • Gynecological conditions and treatments
  • Gestational Trophoblastic Disease Studies
  • Meta-analysis and systematic reviews
  • Ion channel regulation and function
  • Maternal and Perinatal Health Interventions
  • Academic Publishing and Open Access
  • Birth, Development, and Health
  • Cancer-related molecular mechanisms research
  • Social Issues and Policies
  • Periodontal Regeneration and Treatments
  • Folate and B Vitamins Research
  • Testicular diseases and treatments
  • Urticaria and Related Conditions
  • Celiac Disease Research and Management
  • Pluripotent Stem Cells Research

Center for Human Reproduction
2020

National and Kapodistrian University of Athens
2003-2020

Aretaeio Hospital
2020

University of Thessaly
2020

Athens Medical Center
2019

Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and anti-aging process, employing angiogenesis regeneration due to multiple growth factors cytokines involved. Numerous reports shown promising results with use ovarian treatment, regarding reactivation folliculogenesis. This case series on two women premature failure (POF) aged 40 27 years, respectively, one menopausal woman 46 years....

10.1177/0963689719859539 article EN cc-by-nc Cell Transplantation 2019-07-04

Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting clinical routine practice is imperative. This study aims provide pilot data regarding PRP application for rejuvenation. Four studies were conducted poor response (POR), premature insufficiency (POI), perimenopause, and menopause, respectively. Each reports thirty patients, 120 participants recruited total. All provided...

10.3390/jcm9061809 article EN Journal of Clinical Medicine 2020-06-10

This report presents the case of a woman aged 40 who has experienced premature menopause from age 35. Having rejected oocyte donation, she opted for intraovarian injection autologous platelet-rich plasma with aim to rejuvenate ovarian tissue and enable employment her own gametes through in-vitro fertilization. Six weeks following treatment, significant reduction in patient's follicle-stimulating hormone (FSH) levels were noted. A natural fertilization cycle led biochemical pregnancy,...

10.3390/jcm8010001 article EN Journal of Clinical Medicine 2018-12-20

Poor responders are described as those In Vitro Fertilization (IVF) patients who failing to respond controlled ovarian stimulation protocols. Extensive research has focused on crafting the optimal treatment. However, it appears that each approach fails be established effective or guaranteed towards successful management. Platelet-Rich Plasma (PRP) is a novel, highly promising been successfully applied for an array of medical issues. this case series, we present 3 poor responder with common...

10.1159/000491697 article EN Gynecologic and Obstetric Investigation 2018-08-22

Background/Aim: Patients diagnosed with chronic endometritis (CE) may fail to respond standard antibiotic treatment. The driver behind the approach reported here was imperative need for alternative therapeutic solutions. Case Report: This case report presents a woman CE and premature ovarian insufficiency having experienced repeated implantation failures following donated embryo transfers. patient through hysteroscopy, microbiological analysis scanning electron microscopy. Following...

10.21873/invivo.11504 article EN In Vivo 2019-01-01

The present study investigated the response of hypothyroid heart to ischaemia-reperfusion. Hypothyroidism was induced in Wistar rats by oral administration propylthiouracil (0.05%) for 3 weeks (HYPO rats), while normal animals (NORM) served as controls. Isolated hearts from NORM and HYPO were perfused Langendorff mode subjected zero-flow global ischaemia followed reperfusion (I/R). Post-ischaemic recovery left ventricular developed pressure expressed % initial value (LVDP%). Basal expression...

10.1677/joe.0.1780427 article EN Journal of Endocrinology 2003-09-01

Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect endometrial restoration, antibiotic appears perform well. However, regarding the improvement In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, consensus on optimal has yet be reached. This manuscript uniquely brings first report effective employment intrauterine infusion treat CE...

10.1186/s12905-018-0688-8 article EN cc-by BMC Women s Health 2018-12-01

How do stress related phenomena during labor differ between vaginal delivery (VD) and elective cesarean section (CS), remains of heightened interest. The purpose this study is to investigate discrepancies regarding the response VD CS.Cortisol, interleukin 6 (IL-6), growth hormone (GH) insulin-like factor 1 (IGF-1) levels from parturients' peripheral blood were evaluated on three time-points, namely first stage (TP1), two hours post (TP2) 48 h (TP3). Levels also umbilical cord blood. A total...

10.3390/jcm8081112 article EN Journal of Clinical Medicine 2019-07-27

Hypothyroid heart displays a phenotype of cardioprotection against ischemia and this study investigated whether administration dronedarone, an amiodarone-like compound that has been shown to preferentially antagonize thyroid hormone binding receptor α1 (TRα1), results in similar effect. Dronedarone was given Wistar rats (90 mg/kg, once daily (od) for 2 weeks) (DRON), while untreated animals served as controls (CONT). Hypothyroidism (HYPO) induced by propylthiouracil administration. Isolated...

10.1089/thy.2005.15.16 article EN Thyroid 2005-01-01

The present study aims to explore the effectiveness of laparoscopic surgery on women presenting with infertility, unidentified aetiology according standard infertility investigation, and recurrent failed In Vitro Fertilization (IVF) attempts. Identifying correcting possible underlying pathologies by laparoscopy may subsequently enable natural conception in an effort address avoid IVF overuse. One-hundred seven (107) attempts met inclusion criteria. Laparoscopic was performed as endpoint...

10.3390/jcm8040548 article EN Journal of Clinical Medicine 2019-04-22
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