A5058538864- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Metabolism and Genetic Disorders
- Protease and Inhibitor Mechanisms
- Museums and Cultural Heritage
- Pharmacological Effects and Assays
- Congenital Heart Disease Studies
- Atherosclerosis and Cardiovascular Diseases
- Memory, Trauma, and Commemoration
- Cell Adhesion Molecules Research
- Cardiovascular Issues in Pregnancy
- Digital and Traditional Archives Management
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Transplantation: Methods and Outcomes
- Cardiomyopathy and Myosin Studies
- Semiconductor materials and devices
- Lipid metabolism and biosynthesis
- Connexins and lens biology
- Cardiovascular Effects of Exercise
University of Colorado Denver
2008-2014
Children's Hospital Colorado
2013
BackgroundAlthough the pathophysiology and treatment of adult heart failure (HF) are well studied, HF in children remains poorly understood. In adults, adrenergic receptor (AR)-mediated adaptation plays a central role cardiac abnormalities HF, these patients respond to β-blocker (BB) therapy. However, with there is growing body literature suggesting lack efficacy therapies. Due unanticipated differences response therapy paucity data regarding molecular paediatric heart, we investigated...
Decreases in cardiac connexin43 (Cx43) play a critical role abnormal cell-to-cell communication and have been linked to the resistance of female heart arrhythmias. We therefore hypothesized that Cx43 expression would be greater cardiomyocytes than male under pathologic conditions. Adult ventricular myocytes were isolated from rats treated with phenylephrine (PE), well-established stimulus. gene protein was determined. The micro-RNA-1 (miR-1), micro-RNA known control cardiomyocytes, also mRNA...
Children with heart failure are treated similar medical therapy as adults failure. In contrast to failure, these treatment regiments not associated improved outcomes in children. Recent studies have demonstrated age-related pathophysiological differences the molecular mechanisms of between children and adults. There no animal models pediatric cardiomyopathy allow mechanistic studies. The purpose current experiments was develop a mouse model disease test whether influence β-adrenergic...
Atherosclerosis is a systemic disease resulting in plaque formation multiple vascular beds. Despite progress its prevention and treatment, the mechanisms underlying local development, progression, or regression remain poorly understood. To better understand process role for potential new therapeutic targets, current investigative approaches are employing expression profiling of genes proteins.1 Many recent genomic proteomic evaluations atherosclerosis have focused on blood-borne markers due...
Introduction: Single ventricle congenital heart disease (SV) is the leading cause of cardiovascular death and indication for transplantation in infancy. There are no proven therapies SV failure (HF). Human animal models HF demonstrate that myocardial phosphodiesterase-5 (PDE5) increased with cardiac stress treatment a PDE5 inhibitor (PDE5i) results enhanced function prevents remodeling. Sildenafil, PDE5i, increasingly utilized patients suffering from failing SV. The objective this study was...
Background Cardiolipin (CL) is a unique phospholipid that an essential component of the inner‐mitochondrial membrane critical for normal energy metabolism. Biosynthesis CL occurs via enzymatic pathway or through remodeling existing CLs. The content total and (18:2) 4 (tetralinoleic form, normally predominant in heart) are lower ventricular tissue from adults with heart failure secondary to idiopathic dilated cardiomyopathy (IDC). Purpose aim this study was determine expression levels...