A5081200198- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Patient Satisfaction in Healthcare
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- MRI in cancer diagnosis
- Congenital Heart Disease Studies
- Sarcoma Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Neuropeptides and Animal Physiology
- Healthcare Policy and Management
- Protein Degradation and Inhibitors
- Actinomycetales infections and treatment
- Patient-Provider Communication in Healthcare
- Cardiovascular Effects of Exercise
- Urologic and reproductive health conditions
- Ocular Oncology and Treatments
- Hospital Admissions and Outcomes
- Healthcare Operations and Scheduling Optimization
- Ion channel regulation and function
- Transplantation: Methods and Outcomes
- Urological Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
Texas Tech University Health Sciences Center
2015-2022
Texas Tech University
2016-2022
University of Colorado Denver
2010-2019
Pharmacogenetics involves complex interactions of gene products affecting pharmacodynamics and pharmacokinetics, but there is little information on the interaction multiple genetic modifiers drug response. Bucindolol a β-blocker/sympatholytic agent whose efficacy modulated by polymorphisms in primary target (β(1) adrenergic receptor [AR] Arg389 Gly cardiac myocytes) secondary modifier (α(2C) AR Ins [wild-type (Wt)] 322-325 deletion [Del] neurons). The major allele homozygotes minor carriers...
We evaluated the relationship of patient satisfaction to arrival and wait times. also sought determine factors that patients considered important visit experience.A total 361 participants completed a survey in clinic record times various areas then rate levels with these care received. A 211 ranked 6 related experience order important.Early, on time late arriving spent 26.0, 15.5 17.1 minutes waiting room had duration 82.5, 67.9 72.0 minutes, respectively. Significant differences existed...
Several studies in humans or transgenic animals have reported that the 389 Arg Gly polymorphic variation of β1-adrenergic receptor (AR) is associated with differential responses to beta-blocker therapy and/or myocardial disease progression. Analysis changes gene expression an important means defining molecular differences structural functional phenotypic variations. To determine if and between β1389 vs. overexpressors are qualitative quantitative expression, a comprehensive analysis mRNAs...
Renal medullary carcinoma (RMC) is a rare, aggressive primary renal malignancy that classically occurs in adolescent males with sickle cell trait and universally presents metastatic disease at presentation. We report case of young man likely ophthalmic metastasis. also review relevant literature available to date. The patient 20-year-old African-American male past medical history significant for who presented the University Medical Center cough right eye pain 1 month as well painless gross...
Horseshoe kidneys are one of the most common congenital genitourinary malformations and can increase complexity urologic procedures, especially nephrolithiasis. We present a patient who underwent robotic-assisted laparoscopic pyelolithotomy with intracorporeal pyeloscopy stone basketing to treat left lower pole burden located in horseshoe kidney. This procedure provided benefits expanded maneuverability, dexterity, stability, which resulted successful elimination on post-operative imaging....
Recurrence of pure seminoma in atypical lymph node sites, such as the pelvis are rare masses that show clinical signs late disease progression. We report a case 73-year-old male presented with urinary retention and pain his left lower extremity history right radical orchiectomy adjuvant radiation for stage 1 30 years prior. CT showed pelvic mass concerning malignancy. Patient subsequently underwent surgical excision pathology identified recurrence seminoma. This emphasizes etiology late,...
Peroxidation of membrane polyunsaturated fatty acids is a hallmark feature myocardial injury associated with aging and heart failure. We examined the extent to which changes in acid composition predict markers lipoxidative stress failure rat human myocardium. In Fisher 344 rats, was marked desaturation phospholipids, represented by increases 22:6 20:4/18:2 ratio that correlated closely malondialdehyde (MDA) 4‐hydroxnonenal (HNE)‐protein adducts. These phenomena occurred at an earlier age...