A5002522556- Developmental Biology and Gene Regulation
- Microscopic Colitis
- Aquaculture disease management and microbiota
- Autoimmune and Inflammatory Disorders
- Hidradenitis Suppurativa and Treatments
- Eosinophilic Disorders and Syndromes
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Wound Healing and Treatments
- Histiocytic Disorders and Treatments
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Vascular Tumors and Angiosarcomas
- Cellular Mechanics and Interactions
- Hair Growth and Disorders
- Cancer Cells and Metastasis
- Congenital heart defects research
- Neurogenesis and neuroplasticity mechanisms
New York University
2020-2025
National Taiwan University Hospital
2024
National Taiwan University
2008-2022
Intensive cellular movements occur during gastrulation. These rely heavily on dynamic actin assembly. Rho with its associated proteins, including the Rho-activated formin, Diaphanous, are key regulators of assembly in protrusion and migration. However, function Diaphanous gastrulation cell remains unclear. To study role gastrulation, we isolated a partial zebrafish diaphanous-related formin 2 (zdia2) clone N-terminal regulatory domains. The GTPase binding domain zDia2 is highly conserved...
Abstract A delicate balance between proliferating and differentiating signals is necessary to ensure proper growth neuronal specification. By studying the developing zebrafish brain, we observed a specific dynamic expression of microtubule destabilizer gene, stathmin-like 4 ( stmn4 ), in dorsal midbrain region. The was mutually exclusive pan-neuronal marker, elavl3 that indicates its role regulating neurogenesis. We showed knockdown or overexpression resulted premature differentiation...
In the zebrafish lateral line system, interneuromast cells (INCs) between neuromasts are kept quiescent by underlying Schwann (SWCs). Upon severe injuries that cause complete loss of an entire neuromast, INCs can occasionally differentiate into but how they escape from inhibition SWCs is still unclear. Using a genetic/chemical method to ablate neuromast precisely, we found small portion larvae regenerate new neuromast. However, residual regeneration capacity was hindered inhibiting...
Abstract Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease affecting human apocrine sweat gland-bearing regions. One unique feature of HS the development keratinized sinus tracts that grow extensively deep in dermis and are highly immunogenic. Here, we demonstrated stem cell fate infidelity exists tracts, which exhibit features both surface epidermis appendages. Using single transcriptome analyses, finely dissected different compartments epithelium identified their...
ABSTRACT In the zebrafish lateral line system, interneuromast cells (INCs) between neuromasts are normally kept quiescent by underlying Schwann (SWCs). Upon severe injuries that cause complete loss of an entire neuromast, INCs can occasionally differentiate into but how they escape from inhibition SWCs is still unclear. Using a genetic/chemical method to specifically ablate we found small portion larvae regenerate new regeneration was hindered inhibiting macrophages. By in toto imaging,...