A5060008040- Birth, Development, and Health
- Nanoparticles: synthesis and applications
- Zebrafish Biomedical Research Applications
- Environmental Toxicology and Ecotoxicology
- Contact Dermatitis and Allergies
- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
- Data Visualization and Analytics
- Chemical Safety and Risk Management
- Animal testing and alternatives
- Analytical Chemistry and Chromatography
- Neuroendocrine regulation and behavior
- Gold and Silver Nanoparticles Synthesis and Applications
- Per- and polyfluoroalkyl substances research
- Gestational Diabetes Research and Management
- Stress Responses and Cortisol
- Graphene and Nanomaterials Applications
- Nicotinic Acetylcholine Receptors Study
- History and advancements in chemistry
- Computational Drug Discovery Methods
- Cell Image Analysis Techniques
- Metabolomics and Mass Spectrometry Studies
- Microplastics and Plastic Pollution
U.S. Army Engineer Research and Development Center
2020-2022
North Carolina State University
2018-2019
Drawing integrated conclusions from diverse source data requires synthesis across multiple types of information. The ToxPi (Toxicological Prioritization Index) is an analytical framework that was developed to enable integration sources evidence by transforming into integrated, visual profiles. Methodological improvements have advanced and expanded its applicability, necessitating a new, consolidated software platform provide functionality, while preserving flexibility for future updates.We...
Predictive models for the impact of nanomaterials on biological systems remain elusive. Although there is agreement that physicochemical properties (particle diameter, shape, surface chemistry, and core material) influence toxicity, are limited often contradictory, data relating structure to even diameter. Given importance size in determining nanoscale properties, we aimed address this gap by examining effects a defined series gold nanoparticles (AuNPs) zebrafish embryos. Five AuNPs samples...
Abstract Perfluorooctanesulfonic acid (PFOS) is a perfluorinated compound used in many industrial and consumer products. It has been linked to broad range of adverse effects several species, including zebrafish ( Danio rerio ). The embryo widely vertebrate model elucidate potential chemicals because it amenable medium high throughput. However, there limited research on the full extent impact chorion those effects. Results from present study indicate that presence affected timing incidence...
The Toxicological Priority Index (ToxPi) is a method for prioritization and profiling of chemicals that integrates data from diverse sources. However, individual sources ("assays"), such as in vitro bioassays or vivo study endpoints, often feature sections missing data, wherein subsets have not been tested all assays. In order to investigate the effects recommend solutions, we designed simulation studies around high-throughput screening generated by ToxCast Tox21 programs on highlighted...
Solvent Violet 47 (SV47) and Disperse Blue 14 (DB14) are two anthraquinone dyes that were previously used in different formulations for the production of violet-colored smoke. Both have shown potential toxicity; however, there is no comprehensive understanding their effects. Zebrafish embryos exposed to SV47 or DB14 from 6 120 h post fertilization (hpf) assess dyes’ adverse effects on developing embryos. The ability both cross blood–brain barrier was also assessed. At concentrations between...
(1) Background: Disperse Blue 14, Red 9, Solvent 169 and Yellow 33 have been used to color smoke; however, they not comprehensively assessed for their potential health hazards. (2) Methods: To assess the effects of these dyes, zebrafish embryos were exposed from 6 120 h post fertilization (hpf) 10-55 µM 1-50 169, 7.5-13.5 or 133-314 14. Embryos monitored adverse on gene expression at 48 hpf as well mortality, development behavior hpf. The dyes examined cross blood-brain barrier. (3) Results:...
The behaviour of a nursing dam influences the development, physiology, and her offspring. Maternal behaviours can be modulated both by environmental factors, including diet, physical or behavioural characteristics In most studies effects environment on maternal behaviour, F0 dams nurse their own F1 Because are indirectly exposed to stressor in utero these studies, it is not possible differentiate between from direct exposure those mediated changes as consequence exposure. this study, we used...
Chemically induced skin sensitization is a common occupational and public health issue. Regulatory authorities require an assessment of potential to cause for many chemical products. Defined approaches (DASS) can identify sensitizers without using animal tests. While several DASS are internationally accepted by regulatory agencies, the data interpretation procedures vary in logical complexity, manual application be time-consuming or prone error. We developed App, open-source web application,...