A5019338813- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Cancer-related cognitive impairment studies
- Radiation Effects in Electronics
- Boron Compounds in Chemistry
- ATP Synthase and ATPases Research
- Advanced NMR Techniques and Applications
- Tumors and Oncological Cases
- Cerebrovascular and Carotid Artery Diseases
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Research Studies
- Radiation Detection and Scintillator Technologies
- Oral and Maxillofacial Pathology
- Electronic and Structural Properties of Oxides
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Teratomas and Epidermoid Cysts
- Management of metastatic bone disease
Cliniques Universitaires Saint-Luc
2014-2025
UCLouvain
2014-2023
Maastricht University
2019-2022
Maastro Clinic
2022
Maastricht University Medical Centre
2021-2022
Centre Léon Bérard
2020-2021
Georgetown University Medical Center
2020
Georgetown University
2020
Amsterdam UMC Location University of Amsterdam
2019
KU Leuven
2016
Abstract Objective. To compare a not adapted (NA) robust planning strategy with three fully automated online adaptive proton therapy (OAPT) workflows based on the same optimization method: dose mimicking (DM). The added clinical value and limitations of OAPT methods are investigated for head neck cancer (HNC) patients. Approach. strategies aimed at compensating inter-fractional anatomical changes by mimiking different distributions corrected cone beam CT images (corrCBCTs). Order complexity,...
Objective.As proton arc therapy (PAT) approaches clinical implementation, optimizing treatment plans for this innovative delivery modality remains challenging, especially in addressing time. Existing algorithms minimizing time are either optimal but computationally demanding or fast at the expense of sacrificing many degrees freedom. In study, we introduce a flexible method pre-selecting energy layers (EL) PAT planning before actual robust spot weight optimization.Approach.Our EL...
Proton therapy is very sensitive to treatment uncertainties. These uncertainties can induce proton range variations and may lead severe dose distortions. However, most commercial tools only offer a limited integration of these during planning. In order verify the robustness plan, this study aims at developing comprehensive Monte Carlo simulation delivery, including setup errors, variation breathing motion, interplay effect.Most clinically relevant have been modeled implemented in fast engine...
Tumor hypoxia increases resistance to radiotherapy and systemic therapy. Our aim was develop validate a disease-agnostic disease-specific CT (+FDG-PET) based radiomics classification signature.A total of 808 patients with imaging data were included: N = 100 training/N 183 external validation cases for signature, 76 39 the H&N signature 62 36 Lung signature. The primary gross tumor volumes (GTV) manually defined by experts on CT. In order dichotomize between hypoxic/well-oxygenated tumors...
PET-guided dose painting (DP) aims to target radioresistant tumour regions in order improve radiotherapy (RT) outcome. Besides the well-known [18F]fluorodeoxyglucose (FDG), hypoxia positron emission tomography (PET) tracer [18F]fluoroazomycin arabinoside (FAZA) could provide further useful information guide radiation prescription. In this study, we compare spatial distributions of FDG and FAZA PET uptakes lung tumours.Fourteen patients with unresectable cancer underwent 4D-PET/CT on...
Dose painting (DP) aims to improve radiation therapy (RT) outcome by targeting radioresistant tumour regions identified through functional imaging, e.g., positron emission tomography (PET). Importantly, the expected benefit of DP relies on ability PET imaging identify areas which could be consistently targeted throughout treatment. In this study, we analysed spatial stability two potential targets in lung cancer patients undergoing RT: burden surrogate [18F]fluorodeoxyglucose (FDG) and...
Objectives: While hypofractionated stereotactic body radiotherapy (SBRT) has been largely adopted in the adult setting, its use remains limited pediatric patients. This is due, among other factors, to fear of potential toxicities regimens at a young age. In this context, we report preliminary acute (<3 months from SBRT) and middle-term (3–24 months) toxicity results national prospective study investigating SBRT Methods: Between 2013 2019, 61 patients were included. The first 40...
Background and purpose: IMPT faces challenges in lung cancer treatment, like maintaining plan robustness for moving tumors against setup, range errors, interplay effects. Proton Arc Therapy (PAT) is an alternative to maintain target coverage, potentially improving organ at risk (OAR) sparing, reducing beam delivery time (BDT), enhancing patient experience. We aim perform a systematic comparison study between ELSA-PAT assess its potential treatment. Material Methods: 14 Lung plans were...
Background and purpose: Intensity Modulated Proton Therapy (IMPT) faces challenges in lung cancer treatment, like maintaining plan robustness for moving tumors against setup, range errors, interplay effects. Arc (PAT) is an alternative to maintain target coverage, potentially improving organ at risk (OAR) sparing, reducing beam delivery time (BDT), enhancing patient experience. We aim perform a systematic comparison study between IMPT energy layer (EL) spot assignment algorithm – (ELSA-PAT)...
Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare condition characterized by stroke-like deficits, seizures, and headache that can occur years (RT) to the brain. RT cornerstone in treatment of primary brain tumours indicated more than 90% patients. It therefore essential be aware this entity prevent misdiagnosis leading inappropriate treatment. In article, typical imaging findings are presented through case report review literature.
We present the case of a 50-year-old woman previously treated with nivolumab-ipilimumab combination therapy for metastatic melanoma. Despite premature discontinuation these immune checkpoint inhibitors (ICIs) after 2 cycles due to severe immune-related hepatitis, patient achieved complete response. Nine months later, brain magnetic resonance imaging (MRI) showed progression single cerebral lesion, and was referred stereotactic radiosurgery. Unexpectedly, MRI acquired one month later as part...
Abstract Objectives Standard of care treatment for glioblastoma (GBM) involves surgical resection followed by chemoradiotherapy. However, variations in decisions and outcomes exist across hospitals physicians. In Belgium, where oncological is dispersed, the impact hospital volume on GBM remains unexplored. This nationwide study aims to analyse interhospital variability 30-day postoperative mortality 1-/2-year survival patients. Methods Data collected from Belgian Cancer Registry, identified...
Objective. As proton arc therapy (PAT) approaches clinical implementation, optimizing treatment plans for this innovative delivery modality remains challenging, especially in addressing time. Existing algorithms minimizing time are either optimal but computationally demanding or fast at the expense of sacrificing many degrees freedom. In study, we introduce a flexible method pre-selecting energy layers (EL) PAT planning before actual robust spot weight optimization. Our EL pre-selection...