A5100343971- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cellular transport and secretion
- Liver physiology and pathology
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
Xuzhou Medical College
2024
Hospital of Hebei Province
2022
University of Electronic Science and Technology of China
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020
BC Cancer Agency
1999
Abstract MUC15 is a novel mucin associated with the cell membrane that overexpressed in human gliomas. Its function glioma unclear. In this study, high levels were detected tissues and cells. We found transfection siRNA U251 T98G cells reduced expression decreased proliferation, invasion, migration ( P < .05). After transfecting pcDNA3.1‐myc‐His‐MUC15 plasmid to overexpress MUC15, was significantly upregulated increased activated Raf/MEK/ERK signalling pathway ERK inhibitor PD98059 partly...
The combination of anti-angiogenesis agents with immune-checkpoint inhibitors is a promising treatment for patients advanced hepatocellular carcinoma (HCC); however, therapeutic resistance caused by cancer stem cells present in tumor microenvironments remains to be overcome. In this study, we report the first time that Kringle 1 domain human hepatocyte growth-factor α chain (HGFK1), previously described peptide, repressed sub-population CD90+ (CSCs) and promoted their differentiation...