A5013372232- Liver physiology and pathology
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Regulation of Appetite and Obesity
- Lung Cancer Treatments and Mutations
- Dietary Effects on Health
- Diet and metabolism studies
China Medical University
2024
Kunming Medical University
2020-2024
Peking University Cancer Hospital
2024
Peking University
2024
The combination of anti-angiogenesis agents with immune-checkpoint inhibitors is a promising treatment for patients advanced hepatocellular carcinoma (HCC); however, therapeutic resistance caused by cancer stem cells present in tumor microenvironments remains to be overcome. In this study, we report the first time that Kringle 1 domain human hepatocyte growth-factor α chain (HGFK1), previously described peptide, repressed sub-population CD90+ (CSCs) and promoted their differentiation...
Cocaine abuse has been strongly linked to blood-brain barrier (BBB) dysfunction, though the exact mechanism by which cocaine disrupts BBB remains unclear. In this study, we found that treatment reduces expression of glucose transporter 1 (GLUT1) in brain microvascular endothelial cells, a key factor cocaine-induced uptake, leakage, and cognitive impairment. Mechanistically, our results show upregulates miR-320a, turn suppresses GLUT1 via beta 2-adrenergic receptor (ADRB2). Notably,...