A5057480827- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Effects of Radiation Exposure
- Colorectal Cancer Surgical Treatments
- Biliary and Gastrointestinal Fistulas
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Medical Imaging and Pathology Studies
- Eosinophilic Disorders and Syndromes
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
Monash Health
2013-2024
Monash Medical Centre
2010-2024
Hudson Institute of Medical Research
2024
Monash University
2016-2023
Austin Health
2021
University Gastroenterology
2018
Geelong Hospital
2015
Westmead Hospital
2009-2013
St. Michael's Hospital
2010-2013
Royal Hospital for Children
1999
Patients with Barrett's high-grade dysplasia (HGD) or early esophageal adenocarcinoma (EAC) that is shown on biopsy alone continue to undergo esophagectomy without more definitive histological staging. Endoscopic resection (ER) may provide accurate grading and local tumor (T) staging, therapy, complete excision (CBE); however, long-term outcome data are limited. Our objective was demonstrate the effect grade T stage, efficacy, safety of ER for HGD/EAC CBE in suitable patients.This...
Background and study aims: Endoscopic mucosal resection (EMR) for large colonic laterally spreading tumors (LSTs) is a safe, efficacious, cost-effective treatment. The most common serious complication delayed bleeding, which reduces these advantages, but consensus guidelines large-polyp EMR do not exist.
<h3>Aims:</h3> The mammalian target of rapamycin (mTOR), an important regulator protein translation and cell proliferation, is activated in various malignancies. In a randomised controlled trial advanced renal carcinoma patients, targeted therapy to mTOR by means analogues has been shown significantly improve survival. An vitro study revealed that oesophageal squamous (OSCC) lines expression inhibited rapamycin. objectives this histological were determine the proportion OSCC tissues with...
Background: KRAS G12D mutation subtype is present in over 40% of pancreatic ductal adenocarcinoma (PDAC), one the leading global causes cancer death. This retrospective cohort study aims to investigate whether detection PDAC patients a determinant prognosis across all stages disease. Methods: We reviewed medical records 231 presenting with at large tertiary hospital, and compared survival using Kaplan Meier, log-rank test Cox proportional hazards regression model. Results: was not...
Abstract Background Various minimally invasive approaches exist for the management of choledocholithiasis at time laparoscopic cholecystectomy. The aim this study was to compare endoscopic retrograde cholangiopancreatography (ERCP) with bile duct exploration (LBDE) and test hypothesis that intraoperative ERCP is no different LBDE in terms rate clearance or retained stones. Methods Eligible patients undergoing emergency cholecystectomy were randomized a 1 : ratio. primary outcomes rates...
Pancreatic cancer (PC) is largely refractory to existing therapies used in unselected patient trials, thus emphasizing the pressing need for new approaches selection personalized medicine. KRAS mutations occur 90% of PC patients and confer resistance epidermal growth factor receptor (EGFR) inhibitors (e.g., panitumumab), suggesting that wild-type may benefit from targeted panitumumab therapy. Here, we use tumor tissue procured by endoscopic ultrasound-guided fine-needle aspirate (EUS-FNA)...
AIM: Prospective evaluation of repeat endoscopic retrograde cholangiopancreatography (ERCP) for failed Schutz grade 1 biliary cannulation in a high-volume center. METHODS:Prospective intention-to-treat analysis patients referred following recent unsuccessful ERCP.RESULTS: Fifty-one (35 female; mean age: 62.5 years; age range: 40-87 years) with previous were ERCP.The indication ERCP was primarily choledocholithiasis (45%) or pancreatic malignancy (18%).Successful 100%.The precut needle knife...
Abstract Background and Aim: Gastric carcinoid tumors are rare but increasing in incidence. Current recommendations suggest endoscopic resection for type I carcinoids found the stomach, however reports of incomplete have led to difficulty planning future management. Our purpose was describe application multi‐band mucosectomy (MBM) device achieve en‐bloc multiple gastric tumors. Methods: Over a 30‐month period (June 2006–January 2009) eight patients attending assessment were identified at two...
Esophageal lichen planus is a rare condition, and although the majority of cases occur in conjunction with at other sites, endoscopic features are often misinterpreted resulting delay diagnosis. We report series five patients presenting to our unit between 2005 2009. All were female presented dysphagia. Endoscopy demonstrated proximal esophageal stricturing four patients. Characteristic histological findings found Lichen was diagnosed preceded gastrointestinal symptoms, all patients; had...
Abstract Background While endoscopic step‐up approach with delayed drainage (more than 28 days from diagnosis) was shown to produce the best outcomes in treatment of pancreatic walled‐off necrosis (WON), we assessed our single centre experience early versus necrotic collections. Methods Patients who underwent collections between 2011 and 2022 under Monash Health were identified. They excluded if below 18 years old or their follow up data missing. The included patients' medical records,...
Background . Self-expandable metal stents (SEMs) are increasingly being utilised instead of invasive surgery for the palliation patients with malignant gastroduodenal outlet obstruction. Aim To review two tertiary centres’ experience placement SEMs and clinical outcomes. Methods Retrospective analysis prospectively collected data over 12 years. Results Ninety-four (mean age, 68; range 28–93 years) underwent enteral stenting during this period. The primary tumour was gastric adenocarcinoma in...
Dysplasia surveillance in inflammatory bowel disease (IBD) is often suboptimal and deviates from guidelines.
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death and lacks effective treatment options. Diagnostic endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsies represent an appealing source material for molecular analysis to inform targeted therapy, as they are often the only available tissue patients presenting with PDAC irrespective disease stage. However, EUS-FNA typically not used screen precision medicine studies due concerns about low yield quality....
Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) is traditionally performed with patients in the prone position (PP). However, this poses a potentially increased risk of anesthetic complications. An alternative left lateral (LL) decubitus position, which commonly used for endoscopic procedures. Our aim was to compare cannulation rate, time, outcomes ERCP LL versus PP. Patients methods We conducted non-inferiority, prospective, randomized control trial 1:1...
Abstract Background Recent prospective studies suggest combination therapy with immunomodulators improves efficacy, but long‐term data is limited. Aim To assess whether anti‐tumour necrosis factor alpha (anti‐TNF) monotherapy was associated earlier loss of response (LOR) than in a real‐world cohort follow up. Methods A retrospective audit conducted inflammatory bowel disease patients receiving anti‐TNF tertiary centre and specialist private practices. All accurate for commencement adequate...
Impacted esophageal foreign bodies are a relatively common indication for urgent endoscopy [1]. We report case, and demonstrate with video, the endoscopic removal of perforating fish bone closure perforation.
To determine the effect of carbon dioxide insufflation on most important outcome measure colonoscopic quality: adenoma detection rate (ADR).Bowel cancer is second common cause deaths in males and females Australia. Carbon has recent times become methodology choice for screening colonoscopy bowel cancer, as this been shown to have significant advantages when compared with traditional air insufflation.Endoscopies performed over a period 9 months immediately before after implementation at...