A5101520656- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Tracheal and airway disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Urological Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- HIV/AIDS Research and Interventions
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Congenital Diaphragmatic Hernia Studies
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- HIV Research and Treatment
- Cancer Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Electrolyte and hormonal disorders
Sydney Adventist Hospital
2017-2025
Bristol-Myers Squibb (United States)
2023-2025
GLA University
2025
Australian National University
2023-2024
University of Ottawa
2023
Concord Repatriation General Hospital
2017-2023
Parkview Health
2019-2023
Sutter Health
2023
Princess Alexandra Hospital
2014-2022
McMaster University
2022
Patients with Barrett's high-grade dysplasia (HGD) or early esophageal adenocarcinoma (EAC) that is shown on biopsy alone continue to undergo esophagectomy without more definitive histological staging. Endoscopic resection (ER) may provide accurate grading and local tumor (T) staging, therapy, complete excision (CBE); however, long-term outcome data are limited. Our objective was demonstrate the effect grade T stage, efficacy, safety of ER for HGD/EAC CBE in suitable patients.This...
252 Background: Liquid biopsy assays in mCRPC are utilized for treatment eligibility of PARP inhibitors (HRR) and Pembrolizumab (MSI High). These ctDNA targeted gene panels provide translational data beyond mutations. Tumor Fraction (TF), the percentage cfDNA from tumor, is a promising prognostic efficacy biomarker pre-chemo mCRPC, potential predictive to post-chemo PSMA radioligand therapy. Methods: We analyzed run with Illumina-TSO500 CA209-7DX Ph3 trial (Nivo+chemo vs. Chemo chemo-naïve...
To quantify and characterize the nature of cognitive change over 1 year in a cohort HIV-positive former plasma donors rural China.The present study is an observational study.One hundred ninety-two 101 demographically comparable HIV-negative individuals, all donors, who lived part China, received comprehensive medical neuropsychological examinations. At entry, 56% group was on combination antiretroviral treatment 60.9% at follow-up. Multiple regression score approach used with sample to...
A 60-year-old woman was referred to the emergency department after having abdominal pain for 2 weeks eating a whole fish. Outpatient computed tomography (CT) found 45-mm foreign body lodged in distal stomach, with 17 × 14 mm collection and adjacent fat stranding ([Fig. 1]). gastroscopy unsuccessful visualizing bone.
Abstract An emerging literature indicates that HIV infection is associated with deficits in prospective memory (ProM), or the ability to execute a future intention. This offers evidence of neurobiological dissociability ProM from other cognitive abilities and its incremental ecological validity as predictor poorer everyday functioning outcomes (e.g., medication nonadherence). The present study evaluated hypothesis represents unique construct disease. A confirmatory 4-factor structural...
Gastroparesis is a chronic gastric motility disorder. Dopamine D2 /D3 receptor antagonists metoclopramide and domperidone are current treatment options but associated with central nervous system cardiovascular safety concerns, respectively, precluding use. Trazpiroben (TAK-906), dopamine antagonist, under development for of moderate-to-severe gastroparesis. Nonclinical data suggest trazpiroben will have antagonism comparable or domperidone.To evaluate the safety, tolerability,...
Dysphagia palliation in inoperable esophageal cancer continues to be a challenge. Self-expandable metal stents have been the mainstay of endoscopic but significant risk adverse events (AEs). Liquid nitrogen spray cryotherapy is an established modality that can used with systemic therapy. This study reports outcomes cryotherapy, including dysphagia and quality life (QoL), patients receiving therapy.This was prospective multicenter cohort adults who underwent cryotherapy. QoL scores before...
Age, education, and gender are the most common covariates used to define normative standards against which neuropsychological (NP) performance is interpreted, but influences of other demographic factors have begun be appreciated. In developing nations, urban versus rural residence may differentially affect numerous that could influence cognitive test performances, including quality both formal informal educational experiences employment opportunities. Such disparities necessitate corrections...
A 68-year-old man underwent endoscopic ultrasound (EUS) and fine-needle aspiration of a large cystic lesion the pancreatic neck seen incidentally on computed tomography (CT). CT demonstrated nonenhancing, exophytic, multilocular mass, measuring 82 × 72 mm ([Fig. 1], [Video 1]). mural calcific focus was noted posteroinferiorly more solid component posteriorly. The density averaged 19 HU for 40 component.
Dysregulation of histone methylation epigenetic marks may result in intellectual and developmental disability, as seen Kabuki syndrome. Animal data suggest that increasing by inhibiting lysine-specific demethylase 1A (LSD1) improve cognitive outcomes a model TAK-418 is novel LSD1 inhibitor, developed potential therapeutic agent for central nervous system disorders such Here, we report safety, tolerability, pharmacokinetic pharmacodynamic profiles single multiple doses (ClinicalTrials.gov:...
Background HLA-DR*04 was identified as a predictor of HIV-Associated neurocognitive disorder (HAND), low CD4 T-cell responses to HIV, and plasma HIV RNA levels in U.S. cohort. We hypothesized that activation leads poor immune control the CNS, predisposing HAND, but also provided fewer target (activated T-cells) for replication. To assess consistency these HLA Class II associations new cohort extend analysis I, types, neurocognitive, virologic status were examined former donors China. Methods...
Intercostal chest catheter (ICC) insertion is a common hospital procedure with attendant risks including life-threatening complications such as pneumothorax and visceral damage.To investigate the effect of quality improvement (QI) initiative on associated inpatient thoracostomy tube insertion.Following an audit ICC in inpatients over 2-year period we implemented comprehensive QI programme. This involved formal training mandatory use thoracic ultrasound, standardisation documentation,...
A 9-year-old girl presented with sudden onset continuous abdomen pain, oliguria and constipation for 2 days. Ultrasound of the voiding cystourethrography revealed intraperitoneal perforation urinary bladder. Cystoscopy showed two perforations at dome Open surgical repair was performed biopsy taken from their edges. Histopathological examination biopsied material malacoplakia xanthogranulomatous cystitis. The patient doing well 15 months follow-up. Xanthogranulomatous cystitis leading to...
Abstract Purpose Endoscopic ultrasound‐guided gastro‐enterostomy (EUS‐GE) is a relatively novel technique that has been shown to require less re‐intervention than standard endoscopic enteral stenting for gastric outlet obstruction and invasive, quicker, more cost‐effective surgery. This study evaluated the outcomes safety of EUS‐GE in patients treated across two Australian centers. Methods Retrospective data on demographics, presenting symptoms, disease, clinical outcomes, were collected all...
Cholecystectomy and endoscopic retrograde cholangiopancreatography are the gold standard for managing acute cholecystitis malignant biliary obstruction, respectively. Recent advances in therapeutic ultrasound (EUS) have provided alternatives patients whom these approaches fail, namely, EUS-guided gallbladder drainage (EUS-GB) bile duct (EUS-BD). We aimed to assess technical clinical success of techniques largest multicenter cohort published date.A retrospective, multicenter, observational...
A 42-year-old woman was referred for resection of a sporadic, 60-mm, high grade tubulovillous adenoma in the descending duodenum ([Fig. 1]). Submucosal injection gelofusine, methylene blue, and diluted adrenaline 2]) followed by piecemeal endoscopic mucosal (EMR) using an EVIS EXERA II 180 duodenoscope (Olympus, Tokyo, Japan) snare (SnareMaster SD-230U-20; Olympus). Minor bleeding from vessels along lateral margin settled spontaneously, two clips (Instinct Hemoclip; Cook Medical, Limerick,...