A5002039555- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Blood disorders and treatments
- Erythrocyte Function and Pathophysiology
- Trace Elements in Health
- Glutathione Transferases and Polymorphisms
- Blood transfusion and management
- Lymphoma Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Folate and B Vitamins Research
- Osteomyelitis and Bone Disorders Research
- Multiple and Secondary Primary Cancers
- Oral Health Pathology and Treatment
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Palliative Care and End-of-Life Issues
- Magnesium in Health and Disease
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Disease Management Strategies
- Fluoride Effects and Removal
Oxford University Hospitals NHS Trust
2018-2023
John Radcliffe Hospital
1997-2022
University of Oxford
2016-2022
Churchill Hospital
2016-2020
University Teaching Hospital
2018
low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence deficiency absence anaemia is uncertain.to examine associations cognitive impairment, depression and neuropathy with blood measurements folate status people.cross-sectional study general practice Banbury, England.a total 1,000 individuals aged 75 years or living community.low were identified 13% people associated memory impairment depression. After adjustment for age, sex smoking,...
SUMMARY Background/aims : Current Helicobacter pylori eradication therapy for peptic ulcer disease usually involves a 2‐week course of either bismuth preparation or omeprazole in combination with antibiotics. We have studied shorter, 7‐day treatment to assess efficacy and tolerability. Methods Four hundred thirty‐six patients, three non‐randomized groups, received (40 mg mane), amoxycillin (500 t.d.s.) metronidazole (400 t.d.s.): 308 patients the triple 14 days; 80 were treated 7 48 days but...
Accurate diagnosis of rare inherited anaemias is challenging, requiring a series complex and expensive laboratory tests. Targeted next-generation-sequencing (NGS) has been used to investigate these disorders, but the selection genes on individual panels narrow validation strategies have fallen short standards required for clinical use. Clinical-grade negative results requires test distinguish between lack adequate sequencing reads at locations known mutations real absence mutations. To...
Summary With the developing COVID‐19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment schedules. The National Haemoglobinopathy Panel (NHP) has issued guidance on care of sickle cell disease, thalassaemia, Diamond Blackfan anaemia (DBA), congenital dyserythropoietic (CDA), sideroblastic anaemia, pyruvate kinase deficiency other red enzyme membrane disorders. Cascading accurate information for clinicians is paramount...
Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patientsFaced with the rapidly evolving pandemic, March 2020 UK Government advocated strict self-isolation ('shielding') to protect extremely vulnerable patient groups deemed at high risk severe SARS-CoV-2 infection. 1These included children adults sickle cell (HbSS).On advice National Hemoglobinopathy Panel (NHP), a multidisciplinary expert advisory group, shielding guidance was extended all disease (SCD)...
Transfusion-dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS with T2* magnetic resonance imaging scans. 81% had liver and 16·8% cardiac Liver R2* (1000/T2*), but not R2*, was correlated number of units (r=0·72, P<0·0001) ferritin (r=0·53, P<0·0001). The area under the curve a time-ferritin plot found be much greater in loading (median 53·7x10(5) Megaunits vs. 12·2x10(5) Megaunits, P=0·002). HFE, HFE2, HAMP or SLC40A1 genotypes were...
Serology for the presence of anti-D after RhD-incompatible platelet transfusions was performed in 24 RhD-negative patients with haematological disease and 59 non-haematological disease. None were given prophylaxis to prevent RhD immunization. Eight out (13.5%) non-haematology developed detectable anti-D, whereas 0 (0%) haematology formed (P = 0.06). The risk alloimmunization using concentrates prepared by modern technical methods appears be small disease, but is significant...
Both chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are CD5/19 positive. The t(11;14) MCL translocation is identified by fluorescent in situ hybridization (FISH) can distinguish the two disorders. We attempted to identify flow cytometric other markers predictive of a positive FISH test.We examined 100 atypical CLL/MCL cases for demographic, hematological, variables, 96 were tested four known MCL.Twenty-two confirmed as MCL. Multivariate analysis variables associated with...
Recent studies have shown a good response to immunosuppressive treatment with cyclosporin A (CSA) in patients the myelodysplastic syndrome (MDS). We treated six transfusion-dependent MDS CSA for minimum of 3 months. None these showed significant response, while drug was withdrawn 3/6 because intolerable side-effects. Two reasons failure this our can be advanced. Firstly, hypoplastic variant predominated previous contrast ours. Secondly, concomitant use other agents might enhanced effect CSA....
<ns4:p>The multiple clinical benefits of hydroxycarbamide in sickle cell disease are supported by a large body evidence. The maximum tolerated dose (MTD) is the regimen recommended guidelines from panel National Heart, Lung, and Blood Institute (NHLBI) experts, but other dosage regimens have been used babies (BABY-HUG) 9 to 18 months old (20 mg/kg per day) developing countries such as India (10 day); however, there has no direct comparison efficacy, effectiveness, or cost-effectiveness these...
Background: Sickle Cell Disease (SCD) has been designated by WHO as a public health problem in sub-Saharan Africa, and the development of newborn screening (NBS) is crucial to reduction high SCD morbidity mortality. Strategies from field implementation science can be useful for supporting translation NBS evidence income countries unique cultural context Africa. One such strategy community engagement at all levels healthcare system, widely-used framework, “Getting Outcomes®” (GTO), which...
Abstract We report four cases presenting with severe osteoporosis which on further investigation were found to have an underlying lymphoplasmacytoid lymphoma (LPL). Common secondary causes of excluded in each case. Three the responded treatment a biphosphonate. As these lymphomas share some common pathological and clinical features multiple myeloma (MM) association is likely represent more than coincidental finding. The incidence occurring LPL will become clearer if routine imaging carried...