A5005227042- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Colorectal Cancer Surgical Treatments
- Clinical Nutrition and Gastroenterology
- Appendicitis Diagnosis and Management
- Multiple and Secondary Primary Cancers
- Hernia repair and management
- Medical Imaging and Pathology Studies
- Radiopharmaceutical Chemistry and Applications
Fukuyama University
2024-2025
Fukuyama Cardiovascular Hospital
2013-2023
National Hospital Organization
2012-2023
Weatherford College
2023
National Hospital Organization Takamatsu Medical Center
2021
Funabashi Municipal Medical Center
2017
Mitsui Memorial Hospital
2017
National Cancer Center Hospital East
2011
National Institute of Mental Health
2011
Kyorin University Hospital
2011
The growth of human hepatoma Hep 3B cells is potently inhibited by TGF-beta 1 (ID50 = 0.2 ng/ml, 8 pM). A mutant cell line was derived that not in at 5 ng/ml (200 pM) and lacked receptor type II (TGF-beta RII) gene. Transfection the cloned cDNA for RII to this restored expression as well inhibition 1. In both wild-type stably transfected with cDNA, coimmunoprecipitated I presence ligand. These experiments provide direct evidence role inhibitory effect on suggest acts means a heteromeric...
Lymph node metastasis (LNM) has been established as a critical risk factor for prognosis in intrahepatic cholangiocarcinoma (ICC). The clinical implications of lymph dissection (LND) have debated. This study aimed to clarify the prognostic impact LND by multicenter retrospective analysis.A total 310 ICC patients who had undergone curative resection between 2000 and 2016 were retrospectively analyzed. was estimated under an inverse probability treatment weighting (IPTW) approach using...
A right-sided round ligament (RSRL) is a rare congenital anomaly characterized by the umbilical vein being connected to right paramedian trunk. As it associated with intrahepatic vascular anomalies, poses special difficulties in hepatic resection, and an accurate understanding of those anomalies indispensable. An 80-year-old man visited health clinic chief complaint jaundice. Hyperbilirubinemia impaired liver function were detected upon laboratory examination. Therefore, patient was referred...
Objective This study aimed to investigate the clinical significance of preoperative hyperbilirubinemia in Japanese patients and assess its potential as a predictor severity acute appendicitis. Methods We studied 318 with appendicitis who underwent appendectomy between July 2010 June 2017. analyzed data including age, sex, white blood cell count, C-reactive protein (CRP) level, fever, peritoneal irritation signs, serum total bilirubin level risk factors for complicated (perforated or...
Background This study aimed to evaluate the effects of sarcopenia and inflammation on prognosis patients with pancreatic cancer after pancreaticoduodenectomy. Methods Eighty who had undergone pancreaticoduodenectomy for between July 2010 December 2023 were included in this study. The psoas muscle index was used assess sarcopenia. C-reactive protein-to-albumin ratio, prognostic nutritional index, neutrophil-to-lymphocyte platelet-to-lymphocyte ratio calculate preoperative inflammatory marker...
Abstract Objective Recent advancements in genome analyses, including the BRAF gene and mismatch repair (MMR) gene/microsatellite instability (MSI), have revealed biological diversity of colorectal cancer (CRC). BRAF‐mutated CRC has a poor prognosis; however, cases exhibiting deficient MMR (dMMR)/MSI‐high (MSI‐H) mutations demonstrated significant prognostic improvement following recent immune checkpoint inhibitor therapy. Therefore, diagnosis these subtypes is important. This study aimed to...
In the surgical treatment of intrahepatic cholangiocarcinoma (ICC), postoperative complications may be predictive long-term survival. This study aimed to identify an immune-nutritional index (INI) that can used for preoperative prediction complications.Multi-institutional data from 316 patients with ICC who had undergone resection were retrospectively analysed, a focus on various INIs.Severe (Clavien-Dindo grade III-V) identified in 66 (20.8%), including Grade V 7 (2.2%). Comparison areas...
<b><i>Introduction:</i></b> We evaluated the prognostic significance of preoperative albumin-to-globulin ratio (AGR) in patients with hepatocellular carcinoma (HCC) various liver etiologies. <b><i>Methods:</i></b> retrospectively analyzed 157 HCC between July 2010 and February 2021. The relationship clinicopathological variables was investigated using univariate multivariate analyses. Statistical set at <i>p</i> &#x3c; 0.05....
Background The prognosis of intrahepatic cholangiocarcinoma (ICC) has been poor, because the high recurrence rate even after curative surgery. This study aimed to evaluate prognostic impact surgical resection recurrent ICC. Patients and methods A total 345 cases ICC who underwent hepatectomy with intent in 17 institutions were retrospectively analyzed, focusing on patterns treatment modalities for Results Median survival time overall 5-year recurrence-free 17.8 months 28.5%, respectively....
In fulminant hepatic failure (FHF), rapidly progressive cerebral oedema remains the main fatal complication and an obstacle in liver transplantation. A 29-year-old Japanese woman presented with sudden-onset encephalopathy jaundice. Hepatic deteriorated within 2 days of onset She manifested extensory sustained clonus was responsive only to pain. Diffuse noted on brain computerized tomography (CT) scan. Urgent living-donor transplantation (LDLT) at time admission abandoned because...
This study was performed to determine the prognostic value of lymphocyte-to-CRP ratio after curative resection for hepatocellular carcinoma.Between July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical pathologically confirmed carcinoma were included in this retrospective study. Cox regression analysis used evaluate relationship between clinicopathological characteristics recurrence-free survival (RFS) overall (OS). A P-value <0.05 considered...
Lymph node metastases (LNM) are associated with lethal prognosis in intrahepatic cholangiocarcinoma (ICC). Lymphadenectomy is crucial for accurate staging and hopes of possible oncological treatment. However, the therapeutic implications optimal extent lymphadenectomy remain contentious.
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis. Therefore, indicators that can be used for the early prediction of prognosis PDAC are needed. Peroxiredoxin (PRDX) 4 secretion-type antioxidant enzyme located in cytoplasmic endoplasmic reticulum. Recent studies have reported it closely related to development and many types cancer. Perilipin (PLIN) 2 lipid droplet coating protein. The high expression PLIN2 known an indicator some cancer oxidative stress...
Sarcopenia accompanied by systemic inflammation is associated with poor prognosis in patients advanced hepatocellular carcinoma (HCC). However, the effect of sarcopenia combined on HCC who underwent hepatectomy unclear. This study aimed to evaluate and HCC.
Background/Aim: Sarcopenia accompanied by systemic inflammation is associated with poor prognosis in patients cancer. This study evaluated the prognostic significance of sarcopenia (myopenia and myosteatosis) inflammatory markers older (aged ≥80 years) resected biliary tract Patients Methods: who underwent resection for cancer between July 2010 January 2023 at NHO Fukuyama Medical Center were retrospectively reviewed. Preoperative computed tomography measured myopenia myosteatosis, using...
Introduction: This study evaluated the performance of albumin-lymphocyte-globulin-C-reactive protein (CRP) (ALGC) index as a novel prognostic biomarker for hepatocellular carcinoma (HCC) after hepatectomy. Methods: Patients (n = 178) who underwent hepatectomy HCC (July 2010–December 2021) were analyzed. The ALGC was calculated ([albumin × lymphocyte]/[CRP globulin 104]). divided into low group (<1.82; n 81) and high (≥1.82; 97). association with survival assessed by univariate...
It has been shown that the nutritional state of donor may affect outcome liver transplantation. However, many donors staying in intensive care unit for a long period are reduced state. In this study, we investigated effects various methods repletion on transplantation pigs. Donor pigs were divided into three groups according to pretreatment given 7 days before harvesting: group I fasted and received intravenous administration saline; II fed orally; III fasted, but 20% glucose intravenously....