A5059429278- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- HIV/AIDS Impact and Responses
- HIV Research and Treatment
- Global Maternal and Child Health
- Reproductive tract infections research
- Poverty, Education, and Child Welfare
- COVID-19 epidemiological studies
- HIV/AIDS drug development and treatment
- Adolescent and Pediatric Healthcare
- demographic modeling and climate adaptation
- Syphilis Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Sport and Mega-Event Impacts
- Sports, Gender, and Society
- Child Nutrition and Water Access
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Health Policy Implementation Science
- Mental Health Research Topics
- Green IT and Sustainability
- Evolution and Genetic Dynamics
- Cervical Cancer and HPV Research
National Research Foundation
2012-2022
Stellenbosch University
2013-2022
Ghent University
2011-2021
Hasselt University
2014-2021
Ghent University Hospital
2011-2021
Rega Institute for Medical Research
2016-2021
KU Leuven
2016-2021
International Centre for Reproductive Health
2018-2019
ETH Zurich
2016
Openbare Scholengemeenschap De Hogeberg
2010
Abstract Background Human papillomavirus (HPV) and HIV are each responsible for a considerable burden of disease. Interactions between these infections pose substantial public health challenges, especially where prevalence is high HPV vaccine coverage low. Methods Between July 2005 January 2006, cross-sectional community-based survey in Mombasa, Kenya, enrolled female sex workers using snowball sampling. After interview gynaecological examination, blood cervical cytology samples were taken....
Public health responses to HIV epidemics have long relied on epidemiological modelling analyses help prospectively project and retrospectively estimate the impact, cost-effectiveness, affordability, investment returns of interventions, plan design evaluations. But translating model output into policy decisions implementation ground is challenged by differences in background expectations modellers decision-makers. As part PLoS Medicine Collection "Investigating Impact Treatment New...
There is robust clinical evidence to support offering early access antiretroviral treatment (ART) all HIV-positive individuals, irrespective of disease stage, both improve patient health outcomes and reduce HIV incidence. However, as the global guidelines shift meet this evidence, it still largely unknown if ART for (also referred "treatment prevention" or "universal test treat") a feasible intervention in resource-limited countries where approach could have biggest impact on course...
Efficient HIV prevention requires accurate identification of individuals with risky sexual behaviour. However, self-reported data from behaviour surveys are prone to social desirability bias (SDB). Audio Computer-Assisted Self-Interviewing (ACASI) has been suggested as an alternative face-to-face interviewing (FTFI), because it may promote interview privacy and reduce SDB. little is known about the suitability accuracy ACASI in urban communities high prevalence South Africa. To test this, we...
While the HIV epidemic is levelling off in sub-Saharan Africa, it remains at an unacceptably high level. Young people aged 15-24 years remain particularly vulnerable, resulting a regional prevalence of 1.4% young men and 3.3% women. This study assesses effectiveness peer-led prevention intervention secondary schools Rwanda on people's sexual behavior, knowledge attitudes. In non-randomized longitudinal controlled trial, fourteen were selected two neighboring districts Bugesera (intervention)...
Potent antiretroviral therapy (ART) reduces mortality and morbidity in people living with HIV by reducing viral load allowing their immune systems to recover. The reduction soon after starting ART has led the hypothesis that early widespread could prevent onward transmission therefore eliminate epidemic long term. While several authors have argued it is feasible use treatment as prevention (TasP), provided started sufficiently early, others reasonably drawn attention many operational...
In the context of an operational research project in Tete, Mozambique, use of, and barriers to, HIV sexual reproductive health (HIV/SRH) commodities services for female sex workers (FSWs) were assessed as part a baseline situational analysis.In cross-sectional survey 311 FSWs recruited using respondent driven sampling interviewed face-to-face, three focus group discussions held with respectively 6 full-time Mozambican, 7 occasional Mozambican 9 Zimbabwean FSWs, to investigate HIV/SRH...
Different models exist to provide HIV/STI services for most-at-risk populations (MARP). Along the Tete traffic corridor in Mozambique, linking Malawi and Zimbabwe, a night clinic opening between 4 10 PM was established targeting female sex workers (FSW) long-distance truck drivers (LDD). The offers free individual education counselling, condoms, STI care, HIV testing, contraceptive outreach peer education. To evaluate this model, we assessed relevance, service utilisation, efficiency...
Abstract Sport has become a popular tool for HIV prevention, based on claims that it can foster life skills are necessary to translate knowledge, attitudes and behavioural intentions into actual behaviour. Empirical evidence of the effectiveness sport-based prevention programmes is, however, sorely lacking. We therefore conducted cross-sectional survey assessing sexual behaviour determinants thereof among 454 youth Mathare Youth Association (MYSA) in Kenya control group 318 non-MYSA members....
Female sex workers (FSWs) are extremely vulnerable to adverse sexual and reproductive health (SRH) outcomes. To mitigate these risks, they require access services covering not only HIV prevention but also contraception, cervical cancer screening violence. develop context-specific intervention packages improve uptake, we identified gaps in service utilization four different cities. A cross-sectional survey was conducted, as part of the baseline assessment an implementation research project....
Background A baseline cross-sectional survey among female sex workers (FSWs) was conducted in four cities within the context of an implementation research project aiming to improve FSWs' access HIV, and sexual reproductive health (SRH) services. The measured where FSWs seek HIV/SRH care what motivates their choice. Methods Using respondent-driven sampling (RDS), FWSs were recruited Durban, South Africa (n = 400), Tete, Mozambique 308), Mombasa, Kenya 400) Mysore, India 458) interviewed....
Objectives To investigate uptake and provision of antenatal care (ANC) services in the Uzazi Bora project: a demonstration-intervention project for Safe Motherhood prevention mother-to-child transmission HIV Kenya. Methods Data were extracted from clinic, laboratory maternity ward registers all pregnant women attending ANC January 2004 until September 2006 at three clinics Mombasa two rural Kwale district Coast Province, Kenya (n = 25 364). Multiple logistic proportional odds regression...
Abstract Over the past decade, effects of AIDS-related parental death on children's socio-economic, educational and psychological well-being have become apparent. Most studies, however, compared plight so-called AIDS orphans with non-orphaned children only. Consequently, such study designs are unable to establish if cause parents confers additional those parent-bereavement. We therefore conducted a cross-sectional survey assess socio-economic hardship among 140 children, 133 orphaned by...
Objectives To estimate the prevalence of age-disparate (AD) relationships among young black and coloured adults in Cape Town (South Africa) determine socio-demographic predictors individual relationship characteristics women these relationships.Methods A secondary analysis Area Panel Study (N = 1960) data was conducted. Descriptive statistics were used to quantify age-mixing pattern logistic regression identify significant behavioural correlates AD relationships.Results Prevalence high both...
To identify gaps in the use of HIV prevention and care services commodities for female sex workers, we conducted a baseline cross-sectional survey four cities, context an implementation research project aiming to improve sexual reproductive health services.Using respondent-driven sampling, 400 workers were recruited Durban, 308 Tete, Mombasa 458 Mysore interviewed face-to-face. RDS-adjusted proportions estimated by nonparametric bootstrapping compared across cities using post hoc pairwise...
Abstract Patterns of age differences between sexual partners – “age-mixing” may partially explain the magnitude HIV epidemics in Sub-Saharan Africa. However, evidence age-disparity as a risk factor for remains mixed. We used data from socio-centric study behaviour Malawi to quantify age-mixing pattern and find associations relationship characteristics 1,922 participants. Three difference measures were explored predictors prevalent infection. found that each year increase male participant...
The WHO recommends antiretroviral treatment (ART) for all HIV-positive patients regardless of CD4 count or disease stage, referred to as "Early Access ART All" (EAAA). health systems effects EAAA implementation are unknown. This trial was implemented in a government-managed public system with the aim examine "real world" impact on care retention and viral suppression.In this stepped-wedge randomized controlled trial, 14 sector facilities Eswatini were paired randomly assigned stepwise...