A5024271944- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Glycation End Products research
- Blood Coagulation and Thrombosis Mechanisms
- Transplantation: Methods and Outcomes
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Parvovirus B19 Infection Studies
- Venous Thromboembolism Diagnosis and Management
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Blood groups and transfusion
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Hepatitis C virus research
- Liver Diseases and Immunity
- Fibroblast Growth Factor Research
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
University of Alberta
2018-2024
Alberta Hospital Edmonton
2018-2021
Shiraz University of Medical Sciences
2014-2019
Shiraz University
2012-2015
Infection with hepatitis E virus (HEV) is endemic in developing countries and reveals significant regional differences. Several studies have reported transmission via blood transfusion. To date, however, no cases of HEV RNA detection donors been from Iran.The aim this study was to determine the presence plasma samples referred a transfusion center Shiraz southwest Iran. The genotypes were also investigated using nucleotide sequencing.Blood collected 700 who Fars organization January March...
VWF (von Willebrand factor) is an endothelial-specific procoagulant protein with a major role in thrombosis. Aging associated increased circulating levels of VWF, which presents risk factor for thrombus formation.Circulating plasma, cellular protein, and mRNA were determined compared young aged mice. Major organs subjected to immunofluorescence analyses determine the vascular pattern expression presence platelet aggregates. An vitro model aging, using extended culture time endothelial cells,...
Viral load measurements are commonly used to monitor HCV infection in patients with chronic diseases or determining the number of HCV-genomes serum samples after sustained virological response. However, some patients, viral is too low be detected by PCR, especially treatment.The aim this study was develop a highly specific, sensitive, and reproducible in-house quantitative PCR using specific primers probe cited conservative region genome that allows simultaneous detection genotypes 1 - 4.In...
The simple aggregation of insulin under various chemical and physical stresses is still an important challenge for both pharmaceutical production clinical formulation. In the storage form, this protein subjected to modifications which alter its physicochemical properties. Aspirin (acetylsalicylic acid) most widely used medicine worldwide has been indicated acetylate a large number proteins in vitro vivo. study, as treated with aspirin at 37°C, significant level acetylation was observed by...
Abstract Background The role of human parvovirus B19 (B19V) infection in malignant and benign lesions such as head neck squamous cell carcinomas (HNSCCs) oral mucocele has not been established. Herein, we examined, for the first time, presence B19V HNSCCs from Iranian subjects. Methods One hundred eight HNSCC specimens were analyzed using nested polymerase chain reaction (nPCR) TaqMan quantitative PCR assays. Immunohistochemistry procedures performed to evaluate expression VP1/VP2 proteins,...
TIMAP, the endothelial cell-predominant protein phosphatase 1β regulatory subunit also known as PPP1R16B, promotes in vitro cell proliferation and angiogenic sprouting. TIMAP was first identified a target of TGF-β1 mediated repression, but molecular pathways regulating its expression cells are not well-defined. This study examined role BMP9, hypoxia growth factors regulation determined whether plays tumor angiogenesis vivo. which potently activated SMAD1/5/8 pathway cells, significantly...
The six most common missense mutations in the DNA binding domain of p53 are known as "hot spots" and include two frequently occurring (p53-R175H p53-R273H). stability function regulated by various post-translational modifications such phosphorylation, acetylation, sumoylation, methylation, interactions with other proteins including plakoglobin. Previously, using carcinoma cell lines we showed that plakoglobin interacted wild-type several endogenous mutants (e.g., R280K, R273H, S241F, S215R,...
Introduction TIMAP (TGF-β1 inhibited membrane associated protein) is an endothelial cell (EC)-predominant inhibitory protein phosphatase 1β (PP1β) regulatory subunit in the myosin targeting (MYPT) family (J. Biol. Chem. 2294:13280, 2019). promotes proliferation and survival of EC enhances vitro sprouting angiogenesis (Am. J. Physiol. - Renal 307: F623, 2014). Hypothesis Hypoxia stimulates expression EC, enhancing vivo tumor angiogenesis. Methods Mammary adenocarcinoma cells (E0771, syngeneic...