A5013366417- Blood Coagulation and Thrombosis Mechanisms
- Malaria Research and Control
- Pregnancy and preeclampsia studies
- Traditional and Medicinal Uses of Annonaceae
- Fibroblast Growth Factor Research
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Research on Leishmaniasis Studies
- Reproductive System and Pregnancy
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Sphingolipid Metabolism and Signaling
- Maternal and fetal healthcare
- Computational Drug Discovery Methods
Central University of Rajasthan
2016-2021
Abstract Gefitinib, an EGFR tyrosine kinase inhibitor, is used as FDA approved drug in breast cancer and non-small cell lung treatment. However, this has certain side effects complications for which the underlying molecular mechanisms are not well understood. By systems biology based silico analysis, we identified off-targets of gefitinib that might explain drugs. The crystal structure EGFR-gefitinib complex was binding pocket similarity searches on a druggable proteome database (Sc-PDB) by...
Abstract Purpose Extracellular matrix remodeling is essential for extravillous trophoblast (EVT) cell migration and invasion during placental development regulated by metalloproteinases (MMPs) tissue inhibitors of metalloproteases (TIMPs). Sphingosine kinases (SPHK1 SPHK2) synthesize sphingosine‐1‐phosphate (S1P), which works either intracellularly or extracellularly via its receptors S1PR1‐5 in an autocrine paracrine manner. The role SPHKs/S1P regulating the expression MMPs TIMPs EVT mostly...
Abstract Protein kinases of both the parasite and host are crucial in invasion survival might be drug targets against drug-resistant malaria. STK35L1 was among top five hits kinome-wide screening, suggesting a role malaria’s liver stage. The function malaria is not known yet. We found that highly upregulated during infection P. berghei HepG2 cells mice liver. Knockdown remarkably suppressed sporozoite hepatocytes. STAT3 phosphorylated sporozoites infection. activation required for...