A5054375344- Alzheimer's disease research and treatments
- Antimicrobial Peptides and Activities
- Proteoglycans and glycosaminoglycans research
- Parkinson's Disease Mechanisms and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Proteins in Food Systems
- Fibroblast Growth Factor Research
- Supramolecular Self-Assembly in Materials
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Structure and Function
- Biochemical and Structural Characterization
- Wound Healing and Treatments
- Sperm and Testicular Function
- Ginkgo biloba and Cashew Applications
- Endometriosis Research and Treatment
- HIV Research and Treatment
- Connexins and lens biology
- Hemostasis and retained surgical items
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Disorders and Functions
- Diabetic Foot Ulcer Assessment and Management
- Prostate Cancer Treatment and Research
Tel Aviv University
2021-2023
National Institute of Immunology
2021-2022
Central University of Rajasthan
2016-2021
National Dairy Research Institute
2021
Institute of Medical Sciences
2021
University of Southern California
2019
Krishna Institute of Medical Sciences Deemed University
2014
All India Institute of Medical Sciences
2006-2012
ThermoGenesis (United States)
2005-2011
University of Georgia
1988
Cn-AMP2 is an antimicrobial peptide derived from liquid endosperm of coconut (Cocos nucifera). It consists 11 amino acid residues and predicted to have high propensity for β-sheet formation that disposes this be amyloidogenic. In the present study, we examined amyloidogenic propensities in silico then tested predictions under vitro conditions. The study revealed possesses comparable with Aβ. Upon solubilisation agitation aqueous buffer, forms visible aggregates display bathochromic shift...
Protegrin‐4 (PG‐4) is a member of the porcine leukocyte protegrins family cysteine‐rich antimicrobial peptides (AMPs) isolated from Sus scrofa . It consists 18 amino acid residues and works as part innate immune system. In this study, we examined intrinsic aggregation propensity AMP using multiple computational algorithms, namely, TANGO, AGGRESCAN, FOLDAMYLOID, AMYLPRED, ZYGGREGATOR, found that peptide predicted to have high for β sheet formation disposes be amyloidogenic. Under in vitro...
α-Synuclein (αS) is an intrinsically disordered protein whose aggregation and deposition in Lewy bodies involved the progression of Parkinson's disease (PD) other related disorders. The process αS also triggered by mutations like A53T E46K SNCA gene disruption metal-ion homeostasis. Currently, there no obviating therapy available market that could effectively prevent disease. In this backdrop, exists emerging need to consider naturally occurring polyphenols flavonoids as potential...
A 25-year-old female patient came to Department of Obstetrics and Gynaecology with the complaint pain at caesarean scar site, which had increased just before menstrual cycle.She a prior delivery 3 years back.Abdominal examination revealed swelling size about 4 x cm site scar, was firm, tender immobile, initially thought be stitch granuloma.Patient underwent excision swelling.Specimen sent Pathology for histopathological examination.Grossly, it single globular soft tissue mass measured 3x3...
Purpose: Crystallin is a major protein present in eye lens. Peptide fragment αA(66-80) derived from αA-crystallin possesses high aggregation propensity and forms amyloid-like structures. aggregates are known to interact with soluble crystallins destabilize native structures that subsequently undergo aggregation. lens leads reduction opacity, the condition generally referred as cataract. Thus, appears be an important event during cataract development, therefore, inhibition of may attractive...
Accumulation of ordered protein aggregates (or amyloids) represents a hallmark many diseases (e.g., Alzheimer's disease, type II diabetes, Parkinson's etc.), results from intermolecular association partially unfolded proteins/ peptides. Such associations usually take place in highly crowded conditions. The aggregates, which are formed under vitro and vivo conditions exhibit substantial variations their structure function. heterogeneities amyloids might arise due to macromolecular crowding...
Autologous thrombin can be produced by activating the patient's own plasma. By adding calcium chloride (CaCl2) to anticoagulated plasma, coagulation cascade will initiated, and active produced. However, obtained this method degrades very quickly is not practical for use during surgery. The aim of study was investigate stability using processing device (TPD; Thermogenesis Corporation). TPD consists a tubular chamber containing negatively charged surface activation. Plasma (11 ml) reagent...
Pheromone peptides are an important component of bacterial quorum‐sensing system. The pheromone peptide cOB1 (VAVLVLGA) native commensal Enterococcus faecalis has also been identified as antimicrobial (AMP) and reported to kill the prototype clinical isolate strain E. V583. In this study, shown form amyloid‐like structures, a characteristic which is never for so far. With in silico analysis, was predicted be highly amyloidogenic. Further, under experimental conditions, formed aggregates...
A lysozyme isolated from the milk of a monotreme, echidna, Tachyglossus aculeatus multiaculeatus, has been crystallized (space group P2(1), with unit-cell dimensions = 37.1, b 42.0, c 38.1 A, beta 91 degrees and Z 2) structure refined to an R value 0.167 for all measured data in resolution range 7.0-1.9 A. It had previously inferred sequence homology alpha-lactalbumins that echidna (EML) would bind one calcium ion per molecule. This confirmed present study which largest peak difference...
Abstract Purpose Extracellular matrix remodeling is essential for extravillous trophoblast (EVT) cell migration and invasion during placental development regulated by metalloproteinases (MMPs) tissue inhibitors of metalloproteases (TIMPs). Sphingosine kinases (SPHK1 SPHK2) synthesize sphingosine‐1‐phosphate (S1P), which works either intracellularly or extracellularly via its receptors S1PR1‐5 in an autocrine paracrine manner. The role SPHKs/S1P regulating the expression MMPs TIMPs EVT mostly...
Abstract The treatment of epididymal spermatozoa guinea pig and ejaculated rabbit with neuraminidase from Arthrobacter ureafaciens induced significant acrosome reaction while the Cl. perfringens failed to do so. addition inhibitors kept enzyme control level. zona‐free hamster ova test showed that rendered 82% 69% capable fertilization. Thus, seems enhance rate by first capacitating in vitro.
Background: Diabetic foot ulcer is the leading cause of non-traumatic lower extremity amputations. A prospective casecontrol study was carried out on 50 patients with diabetic ulcers (cases) and non-diabetic (controls) to determine microbiological profile, their antibiotic sensitivity patterns along different demographic parameters. The prevalence extended-spectrum beta-lactamases (ESBLs) producers, carbapenemase methicillin-resistant Staphylococcus aureus among isolates potential risk...
Heparin is naturally occurring polysaccharides which interacts with seminal plasma proteins and regulate multiple steps in fertilization process. Qualitative quantitative information regarding the affinity for heparin-seminal interactions not generally well documented there are no reports of a comprehensive analysis these human plasma. Such should improve our understanding how GAGs especially heparin present reproductive tract fertilization. In this study, we use SPR to study various...
Abstract Ultrafine Gold nanoparticles (Au NPs) functionalized with various biomolecules constitute an alternative to antibodies as anti‐amyloidogenic agents. However, generating stable ultrafine Au NPs high surface activity is challenging. Here, the capacity of phosphate groups in used stabilize NPs. The characteristics decorated adenosine mono‐, di‐, and tri‐phosphate are compared well peptide nucleic acid‐containing controls. Among them, ATP‐Au found be superior having small size (2–4 nm)...