A5029156207- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal Tumor Research and Treatment
- Stochastic Gradient Optimization Techniques
- Heat shock proteins research
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- thermodynamics and calorimetric analyses
- Intestinal Malrotation and Obstruction Disorders
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
- Privacy-Preserving Technologies in Data
- Liver physiology and pathology
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Chromatin Dynamics
- Surgical site infection prevention
Lanzhou University
2021-2025
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2024
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2024
Gansu Provincial Hospital
2021-2022
First Hospital of Lanzhou University
2021
Institute of Bioinformatics
2018-2019
Tsinghua University
2018-2019
National Institute on Aging
2010-2012
The potential of medical imaging to non-invasively assess intratumoral heterogeneity (ITH) is increasingly being recognized. This study aimed investigate the value ITH-based deep learning model for preoperative prediction histopathologic grade in hepatocellular carcinoma (HCC). A total 858 patients from primary cohort and two external cohorts were included. 3.0T or 1.5T axial portal venous phase MRI images collected. We conducted radiomics feature-driven K-means clustering automatic...
Knowledge Distillation (KD) aims at transferring the knowledge of a well-performed neural network (the {\it teacher}) to weaker one student}). A peculiar phenomenon is that more accurate model doesn't necessarily teach better, and temperature adjustment can neither alleviate mismatched capacity. To explain this, we decompose efficacy KD into three parts: correct guidance}, smooth regularization}, class discriminability}. The last term describes distinctness wrong probabilities} teacher...
Interleukin-6 (IL-6) is a proinflammatory cytokine that exerts wide range of cellular, physiological, and pathophysiological responses. Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer activator transcription-3 activation downstream signaling. To further elucidate biological properties PDTC, global gene expression profiling human HepG2 hepatocellular carcinoma cells was carried out after treatment with PDTC or for up 8...
Objective We aimed to investigate the efficacy and safety of enhanced recovery after surgery (ERAS) for patients with gastric cancer undergoing minimally invasive (MIS).Methods searched PubMed, Cochrane Library, Web Science, Embase, CNKI, VIP, WanFang, CBM relevant RCTs from database inception until December 2021, studies that compared ERAS traditional care (TC) in MIS cancer.Results A total 25 comprising 2809 were included this study. When TC group, group had a shorter postoperative...
Background Transcription factor is one of the most important regulators in transcriptional process. Nevertheless, functional interpretation transcription factors still a main challenge due to poor performance methods relating regulatory regions genes. Epigenetic information, such as chromatin accessibility, contains genome‐wide knowledge about regulation and thus may shed light on factors. Methods We propose EpiFIT (Epigenetic based Functional Interpretation factors), tool infer functions...
Members of the heat shock protein-90 (Hsp90) family are key regulators biological processes through dynamic interaction with a multitude protein partners. However, transient nature these interactions hinders identification Hsp90 interactors. Here we show that chemical cross-linking ethylene glycolbis (succinimidylsuccinate), but not shorter cross-linkers, generated an abundant 240-kDa heteroconjugate molecular chaperone in different cell types. The combined use pharmacological and genetic...