A5100399800- Liver physiology and pathology
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- HIV/AIDS drug development and treatment
- Cancer Mechanisms and Therapy
- HIV-related health complications and treatments
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- HIV Research and Treatment
- Cancer, Hypoxia, and Metabolism
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Ultrasound in Clinical Applications
- Cancer Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Pancreatic function and diabetes
- Intracranial Aneurysms: Treatment and Complications
- Gastric Cancer Management and Outcomes
- Health Promotion and Cardiovascular Prevention
- Medicinal Plants and Bioactive Compounds
Sichuan University
2011-2025
West China Hospital of Sichuan University
2011-2025
Air Force Medical University
2025
Xijing Hospital
2025
Chinese PLA General Hospital
2025
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Zunyi Medical University
2023
China Rehabilitation Research Center
2022
Capital Medical University
2013-2022
Abstract The role of cancer stem cells (CSCs) in inducing the recurrence hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a dramatic increase plasma vascular endothelial growth factor (VEGF) and an induction local CD133 + CSCs are associated with early HCC recurrence, suggesting VEGF expression tumour stemness contribute to relapse. In vitro studies demonstrated VEGF, via activation VEGFR2, increased number enhanced their capacity for...
Hypertension constitutes the primary health burden of cardiovascular diseases, and global control blood pressure (BP) remains insufficient. Single pill combinations (SPCs) are employed as a means to streamline management poor BP due non-adherence treatment inertia. The compound reserpine triamterene tablets constitute quadruple SPC, comprising 0.1 mg, dihydralazine 12.5 hydrochlorothiazide mg mg. It is widely in medical institutions has favourable efficacy, tolerability cost-effectiveness....
The potential of medical imaging to non-invasively assess intratumoral heterogeneity (ITH) is increasingly being recognized. This study aimed investigate the value ITH-based deep learning model for preoperative prediction histopathologic grade in hepatocellular carcinoma (HCC). A total 858 patients from primary cohort and two external cohorts were included. 3.0T or 1.5T axial portal venous phase MRI images collected. We conducted radiomics feature-driven K-means clustering automatic...
Nucleos(t)ide analogues (NAs) are widely used in anti-hepatitis B virus (anti-HBV) therapy for effective inhibition of HBV replication. However, resistance to NAs has emerged, resulting reactivation and disease recurrence. Data on the current dynamics still rare China. This study analysed 4491 plasma samples with primary genotypic mutations representative general situation northern China from 2009–2016. We found that entecavir (ETV), representing 57.6% (12 713/22 060) NA users North 2016,...
Abstract Sorafenib is the standard first‐line systemic chemotherapeutic drugs for advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib frequently observed in clinical practice. In this study, we first produced three (SR) HCC cell lines by using two human (Hep3B and Huh7) a primary line. We identified that epidermal growth factor receptor (EGFR) Kruppel‐like 4 (KLF4) are dramatically increased SR lines. Either inhibition of tyrosine kinase activity EGFR with...
// Kai Liu 1, 2, * , Tao Jiang Yabo Ouyang 2 Ying Shi Yunjin Zang 1 Ning Li Shichun Lu Dexi Chen Beijing You’an Hospital, Capital Medical University, Beijing, 100069, China Institute of Hepatology, These authors have contributed equally to this work Correspondence to: Lu, e-mail: Isc620213@aliyun.com Chen, dexi0963@yahoo.com Keywords: ASPP2, p53, SOS1, EGFR, apoptosis Received: December 08, 2014 Accepted: April 15, 2015 ...
YKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well cardiovascular diseases. We investigated the association between expression in epicardial adipose (EAT) atrial fibrosis patients with fibrillation (AF). Blood samples, subcutaneous (SAT), paracardial (PAT), EAT, adjacent myocardium were acquired from receiving coronary artery bypass grafts. The divided into AF group (n = 28) sinus rhythm (SR) 36). did not detect significant difference serum levels...
As an alternative pathway for liver regeneration, progenitor cells and their derived ductular reaction increase during the progression of many chronic diseases. However, mechanism underlying hepatocyte repopulation after injury remains unknown. Here, we conducted cell lineage tracing in mice found that fewer than 2% hepatocytes were from 9 weeks with a choline-deficient diet supplemented ethionine (CDE), this percentage increased approximately three-fold 3 recovery. We also proportion double...
Radiofrequency ablation (RFA) represents a valuable choice in hepatocellular carcinoma (HCC); however, local recurrence of HCC is common after RFA. Here, 20 primary patients treated by RFA were enrolled. Before (termed 0d) and treatment for 1 7 days 1d 7d, respectively), plasma noncancerous tissue collected. ELISA assay showed that C-X-C motif chemokine 10 (CXCL10) was increased ten (type I patients) but decreased the other II patients). The mean interval type less than patients....
This study aimed to investigate clinical and angiographic outcomes of Pipeline embolization device (PED) treatment large or giant basilar artery (BA) aneurysms examine associated factors.Clinical data 29 patients (18 men, 11 women) with BA were retrospectively examined. Mean age was 44.1 ± 21.2 years (range, 30-68). aneurysm size 22.2 8.3 mm 12.0-40.1).Mean follow-up 18.3 3.4 months 4.5-60). The rate adequate aneurysmal occlusion (O'Kelly-Marotta grade C-D) 87%. overall complication 44.8%;...
Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was suppress TP53 and induce the expression of transcription factor NANOG maintain cancer stem cells promote hepatocarcinogenesis.
As the backbone of highly active antiretroviral therapy (HAART), nucleoside reverse transcriptase inhibitors (NRTIs) have effectively improved outcomes for HIV-infected patients. However, long-term treatment with NRTIs can cause a series pathologies associated mitochondrial toxicity. To date, status and mechanism toxicity induced by are still not clear, especially in children. part national pediatric HAART program China, our study focused on its potential HIV-1-infected children who were...
Previous studies suggested that RsaI/PstI and DraI polymorphisms on cytochrome P450 2E1 (CYP2E1) may be associated with susceptibility to gastric cancer (GC). However, this association remains ambiguous. A meta-analysis of previously published was performed in an attempt elucidate association. The odds ratio 95% confidence interval were used assess the strength In overall analyses DraI, no identified. subgroup analyses, identified increase risk GC smoking population. addition, previous...
The mechanisms behind HIV-1-associated neurocognitive disorders are still unclear. Apoptosis-stimulating protein 2 of p53 (ASPP2) is a damage-inducible p53-binding that stimulates p53-mediated apoptosis and transactivates proapoptotic cell cycle regulatory genes. It has been reported ASPP2 specific function in the death retinal ganglion cells development Alzheimer's disease. In this study, we used knockout mice primary cerebrocortical neuron culture to analyze role interaction between with...
There is growing concern about mitochondrial DNA (mtDNA) mutations with long-term NRTI exposure in HIV-1 infected children.Twenty-four children who started ART more than 2 years earlier had an excellent virological response and not changed their regimen were enrolled retrospectively. Their corresponding PBMCs 2009 (T1), 2010 (T2) 2013 (T3) included. Sequencing of the entire mtDNA using next-generation sequencing revealed spectrum variants.The trend showed that number during occurred as T1 <...
AIM:To investigate the effect of hepatocyte nuclear factor 4α (HNF4α) on differentiation and transformation hepatic stellate cells (HSCs). METHODS:By constructing recombinant adenovirus vector expressing HNF4α shRNA vector, manipulating expression in HSC-T6 cells, we explored influence its induction capacity rat HSCs into hepatocytes. RESULTS:With increased mediated by AdHNF4α, relative Nanog was downregulated (98.33 ± 12.33 vs 41.33 5.67, P < 0.001).Consequently, G-P-6 PEPCK upregulated...