A5072943126- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Infectious Encephalopathies and Encephalitis
- Wnt/β-catenin signaling in development and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microtubule and mitosis dynamics
- Calcium signaling and nucleotide metabolism
- Vitamin C and Antioxidants Research
- Cellular Mechanics and Interactions
- Piperaceae Chemical and Biological Studies
- Cholesterol and Lipid Metabolism
- Genetic Neurodegenerative Diseases
- MicroRNA in disease regulation
- Immune cells in cancer
- Skin and Cellular Biology Research
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- Endoplasmic Reticulum Stress and Disease
University of Ferrara
2020-2023
Bambino Gesù Children's Hospital
2018-2021
University of Rome Tor Vergata
2016-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Université Paris Cité
2011
Délégation Paris 7
2011
Centre National de la Recherche Scientifique
2011
Autophagy is an intracellular degradation pathway whose levels are tightly controlled to secure cell homeostasis. Unc-51-like kinase 1 (ULK1) a conserved serine-threonine that plays central role in the initiation of autophagy. Here, we report upon autophagy progression, ULK1 protein specifically down-regulated by E3 ligase NEDD4L, which ubiquitylates for proteasome. However, whereas degraded, mRNA actively transcribed. Upon reactivation mTOR-dependent synthesis, basal promptly restored, but...
Article1 May 2021Open Access Source DataTransparent process TFG binds LC3C to regulate ULK1 localization and autophagosome formation Marianna Carinci Department of Pediatric Hemato-Oncology Cell Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy Medical Sciences, University Ferrara, Laboratory Technologies for Advanced Therapy (LTTA), Technopole Search more papers by this author Beatrice Testa Biology, Rome Tor Vergata, Matteo Bordi Giacomo Milletti Massimo Bonora Laura...
Abstract Background The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of inflammatory process in propagation viral infection. main consequence COVID-19 is induction a diffuse pro-inflammatory state, also defined as cytokine storm, which affects different organs, but mostly lungs. We aimed prove efficacy cinnamaldehyde, active compound cinnamon, an anti-inflammatory compound, able reduce SARS-CoV-2 induced storm. Results enrolled 53 patients...
Autophagy is a highly conserved process that acts sequestering cytoplasmic components for their degradation by the lysosomes. It consists of several sequential steps have to be finely regulated ensure both its progression and termination. Post-translational modifications (PTMs) play an important role in regulating ATG proteins function different stages autophagy. Recently, we demonstrated that, during prolonged starvation, ULK1 protein specifically ubiquitylated NEDD4L, this regulation...
Abstract Introduction: The recent pandemic outbursts, due to SARS-CoV-2, has highlighted once more the central role of inflammatory process in propagation viral infection. In fact, main consequence COVID-19 is induction a diffuse pro-inflammatory state, also defined as cytokine storm, that affects different organs, but mostly lungs. Therefore, despite progress vaccination campaign, high mutability this virus requires effective pharmaceutical approaches aimed reduce spread. Methods effect...