A5101976615- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Pharmacogenetics and Drug Metabolism
- Telomeres, Telomerase, and Senescence
- Biochemical and Molecular Research
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Single-cell and spatial transcriptomics
- Traditional Chinese Medicine Studies
- Mesoporous Materials and Catalysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders
- Lung Cancer Research Studies
- Diet and metabolism studies
- Biological Research and Disease Studies
- Chronic Myeloid Leukemia Treatments
- Clinical Laboratory Practices and Quality Control
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Monoclonal and Polyclonal Antibodies Research
- Digestive system and related health
- Sepsis Diagnosis and Treatment
Stanford University
2025
Institute on Aging
2024
University of Minnesota
2024
University of Minnesota Medical Center
2024
University of Minnesota System
2024
Karolinska University Hospital
2008
Karolinska Institutet
2008
University Hospital Münster
2003
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2003
Zentrum für Kinderheilkunde
2003
Abstract The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis repair, immune reactivity, pathologies driven by aberrant phenotypes. spatial organization of proteins central these processes. High-resolution fluorescence microscopy proximity labeling have advanced studies protein associations, but the complete proteome remains uncharted. In this study, we systematically mapped human T-lymphocytes...
Hutchinson–Gilford progeria syndrome (HGPS) is a rare progeroid caused by mutations in the <i>LMNA</i> gene. Currently there no treatment available for HGPS, but promising results from several studies using farnesyl transferase inhibitors (FTIs) on cells and animal models of HGPS have been published clinical trial FTIs has started patients with HGPS. However, data treated come where was before pronounced disease development. This study used an inducible transgenic model abnormalities skin...
Carbamylphosphate synthetase 1 (E.C. 6.3.4.16) deficiency is a rare autosomal recessive disorder of the urea cycle that can result in severe neonatal hyperammonemia. Since genomic structure CPS1 gene was not yet elucidated, mutation detection performed by analysis transcripts past. Here, we present entire DNA sequence human including all exon-intron boundaries. Moreover, six patients leading to 9 novel mutations missense c.2528T>C and c.2623A>G, nonsense c.712C>T c.2115ins35bp, splice site...
Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these increases with age emerging data implicate senescence-associated maladaptive signaling as a potential contributor sepsis septic shock. senolytic drug fisetin promotes clearance senescent is hypothesized mitigate responses infection. We are conducting multi-center, randomized, double-blinded, adaptive allocation phase 2 clinical trial assess the efficacy in preventing deterioration...
<title>Abstract</title> Age is a major risk factor for liver cancer, as the case most adult human cancers. However, underlying mechanisms are not well defined. A better understanding of role aging in and other cancers can facilitate approaches assessment, early detection prevention. We hypothesize that age-driven changes render aged more sensitive to oncogenic stress hence tumorigenesis. To investigate how with age, we documented immune profile, transcriptome epigenome healthy livers from...
We produced three batches of a human-serum-based enzyme reference material (ERM) enriched with human aspartate aminotransferase (EC 2.6.1.1), alanine 2.6.1.2), creatine kinase 2.7.3.2), and lactate dehydrogenase 1.1.1.27). The added enzymes were not exhaustively purified; thus the final ERMs contained some as contaminants, which only glutamate activity might interfere. stability during storage after reconstitution was good. commutability four in ERM also good, except when German or...