A5020788310- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Acute Ischemic Stroke Management
- Mitochondrial Function and Pathology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- CRISPR and Genetic Engineering
- Forensic Toxicology and Drug Analysis
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Ion channel regulation and function
- Genomics and Chromatin Dynamics
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Suicide and Self-Harm Studies
Broad Institute
2020
Allen Institute for Brain Science
2019
Icahn School of Medicine at Mount Sinai
2019
Children's Hospital of Philadelphia
2019
University of Pennsylvania
2018-2019
Columbia University
2015-2018
MIND Research Institute
2015-2018
Weill Cornell Medicine
2015-2018
New York Psychoanalytic Society and Institute
2015-2018
Cornell University
2011-2018
Radiation-induced inhibition of rapamycin-sensitive pathway and its effect on the cellular response to radiation were studied in human breast cancer cell line MCF-7. Both rapamycin shared molecular targets induced similar physiologic responses. Each these treatments increased immunostaining mammalian target (mTOR) nucleus, led decreased phosphorylation autophosphorylation site Ser2481. In addition dephosphorylation established mTOR downstream effectors 4E-binding protein 1 p70 ribosomal S6...
Abstract CACNA1I , a schizophrenia risk gene, encodes subtype of voltage-gated T-type calcium channel Ca V 3.3. We previously reported that patient-derived missense de novo mutation (R1346H) impaired 3.3 function. Here, we generated 3.3-RH knock-in animals, along with mice lacking 3.3, to investigate the biological impact R1346H (RH) variation. found RH altered cellular excitability in thalamic reticular nucleus (TRN), where is abundantly expressed. Moreover, produced marked deficits sleep...
The nucleus accumbens (Acb) shell and caudate-putamen (CPu) are respectively implicated in the motivational motor effects of dopamine, which mediated part through dopamine D₂-like receptors (D₂Rs) modulated by activation cannabinoid-1 receptor (CB₁R). D(₂/D3) agonist, quinpirole elicits internalization D₂Rs isolated cells; however, dendritic axonal targeting may be highly influenced circuit-dependent changes vivo potentially endogenous CB₁R activation.We sought to determine whether alters...
Summary The use of stem cell derived neurons for cell-based therapies is limited by a protracted maturation. We present novel approach accelerating the post-mitotic maturation human interneurons via activation mTOR signaling. Lox sites were placed within PTEN , key inhibitor, in cortical interneuron (CIn) reporter line. Following directed differentiation and purification FACS, CIns exposed to Cre-expressing lentivirus, then transplanted into mouse neocortex or plated onto cultured rat...
Adolescence is a transition period during which social interaction necessary for normal brain and behavior development. Severely abnormal interactions adolescence can increase the incidence of lifelong psychiatric disease. Decreased prepulse inhibition (PPI) quantifiable hallmark some illnesses in humans be elicited rodents by isolation rearing throughout adolescent period. PPI measure sensorimotor gating nucleus accumbens (Acb) crucially involved. The Acb comprised core shell subregions,...