Abstract Rapid variations in cortical state during wakefulness have a strong influence on neural and behavioural responses are tightly coupled to changes pupil size across species. However, the physiological processes linking largely unknown. Here we demonstrate that these rapid variations, both quiet waking locomotion, highly correlated with fluctuations activity of corticopetal noradrenergic cholinergic projections. dilations associated phasic axons, whereas longer-lasting pupil, such as...

Motoneuron death after spinal cord injury or disease results in muscle denervation, atrophy, and paralysis. We have previously transplanted embryonic ventral cells into the peripheral nerve to reinnervate denervated muscles reduce but reinnervation was incomplete. Here, our aim determine whether brief electrical stimulation of neurons peripheralnerve changes motoneuron survival, axon regeneration, function because neural depolarization is crucial for neuron survival may promote...

Few options exist for treatment of pervasive motoneuron death after spinal cord injury or in neurodegenerative diseases such as amyotrophic lateral sclerosis. Local transplantation embryonic motoneurons into an axotomized peripheral nerve is a promising approach to arrest the atrophy denervated muscles; however, muscle reinnervation limited by poor survival. The aim present study was test whether acute electrical stimulation transplanted neurons promotes survival, axon growth, and...

Data imbalance is a challenging and common problem in data mining machine learning areas, has attracted significant research efforts. A set considered imbalanced when the instances (samples) are not close to uniformly distributed across different classes/categories, which very real-world sets. It likely result biased classification results. In this paper, two-phase framework proposed make of more accurate stable. The based on correlations generated between concepts. general idea identify...

Abstract Motoneurons die in diseases like amyotrophic lateral sclerosis and after spinal cord trauma, inducing muscle denervation. We tested whether transplantation of embryonic cells with neurotrophic factors into peripheral nerve adult rats improves reinnervation motor unit function more than alone. One week sciatic section, ventral were transplanted the tibial or without glial cell line‐derived factor, hepatocyte growth insulin‐like factor‐1. These represented only neuron source for...

In recent years, we have witnessed a deluge of multimedia data such as texts, images, and videos. However, the research managing retrieving these efficiently is still in development stage. The conventional tag-based searching approaches suffer from noisy or incomplete tag issues. As result, content-based management framework has become increasingly popular. this direction, high-level semantic concept mining retrieval one fastest developing topics requesting joint efforts researchers both...

Motoneurons die following spinal cord trauma and with neurological disease. Intact axons reinnervate nearby muscle fibers to compensate for the death of motoneurons, but when an entire motoneuron pool dies, there is complete denervation. To reduce denervation atrophy, we have reinnervated muscles in Fisher rats from local transplants embryonic motoneurons peripheral nerve. Since growth neurons activity dependent, our aim was test whether brief electrical stimulation immediately after...

In this paper, we study the effects of neurofeedback method surface EMG on electrophysiology and evaluate its postural control, balance, motor function using relevant scales. We optimize rehabilitation intervention system based EMG, objective assessment initially try to apply mirror therapy treatment EMG. According different methods, they were divided into drug-only group, drug combined with electroacupuncture facial muscle training group. Starting from 10th day disease course, a course 15...

When limb movements are evoked by electrical stimulation, muscle contraction (e.g. 15-20 ms) and relaxation fast would be poorly sampled video-capture with average frame rates of 60 Hz. Our aim was to design a device capable monitoring ankle joint excursion nerve stimulation in anesthetized rats. A custom footplate coupled the wiper low-torque rotary style potentiometer so output voltage proportional dorsiflexion plantarflexion. Anesthetized rats lay prone hip knee clamped at 90o. The foot...

The substantial time lag that is often present when uncovering accounting misconduct has been largely ignored in prior misstatement prediction literature which causes hindsight biases performance evaluation. In this study, we adapt the restatement models for detection to mimic a realistic framework. Our framework enables real-time risk predictions and not hindered by suffered current literature. model evaluation, advocate an economic measure reflects value relevance of predicted risk. We...