A5012778421- Polymer Surface Interaction Studies
- Dental materials and restorations
- Chemical Reactions and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Photopolymerization techniques and applications
- Advanced Polymer Synthesis and Characterization
- Synthesis and properties of polymers
- Bone Tissue Engineering Materials
- Surgical Sutures and Adhesives
- Surface Modification and Superhydrophobicity
- Chemical Reaction Mechanisms
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Platelet Disorders and Treatments
- Antimicrobial agents and applications
- Aerogels and thermal insulation
- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Nanofabrication and Lithography Techniques
- Facial Trauma and Fracture Management
- Click Chemistry and Applications
- biodegradable polymer synthesis and properties
Nanyang Technological University
2018-2022
Bioadhesives are a current unmet clinical need for mending of blood contacting soft tissues without inducing thrombosis. Recent development carbene precursor bioadhesives with the advantages on-demand curing, tuneable modulus, and wet adhesion have been synthesized by grafting diazirine onto poly (amidoamine) (PAMAM-G5) dendrimers. Herein, structure activity relationships platelet activation is evaluated first time on cured PAMAM-g-diazirine bioadhesives. Three strategies were employed to...
Driven by the clinical need for a strong tissue adhesive with elastomeric material properties, departure from legacy crosslinking chemistries was sought as multipurpose platform mending. A fresh approach to bonding wet substrates has yielded synthetic biomaterial that overcomes drawbacks of free-radical and nature-inspired bioadhesives. food-grade liquid polycaprolactone grafted carbene precursors yields CaproGlu. The first-of-its-kind low-viscosity prepolymer is VOC-free requires no...
Voltage-activated adhesion is a relatively new discovery that relies on direct currents for initiation of cross-linking. Previous investigations have found are linearly correlated to the migration rates electrocuring, but this limited by high voltages exceeding 100 V with instances incomplete curing voltage-activated adhesives semiconducting substrates. Practical applications electrocuring would benefit from lower mitigate high-voltage risks, especially regard potential medical applications....
Carbene-based macromolecules are an emerging new stimuli-sensitive class of biomaterials that avoid the impediments free radical polymerization but maintain a rapid liquid-to-biorubber transition. Activation diazirine-grafted polycaprolactone polyol (CaproGlu) is limited to UVA wavelengths have tissue exposure constraints and light intensities. For first time, circumvented with visible light-emitting diodes at 445 nm (blue) rapidly activate diazirine-to-carbene covalent cross-linking....
Abstract Photoactivation of aryl‐diazirines is an emerging method rapid, covalent crosslinking under ambient conditions. These attributes make those compounds candidates for grafting onto inert polymer backbones in order to produce stimuli‐sensitive biomaterials. However, no risk assessments are available gauge the toxicity leachable components after activation. Herein, a biomaterial formulated from diazirine‐grafted polycaprolactone tetrol. Also known as CaproGlu, this undergoes...
Trifluoromethyl phenyl diazirine (TPD) molecules are relatively stable carbene precursors, that readily form carbon covalent bonds with proteins. The stability of the diazoalkane intermediates is unknown, as factors which control carbene/diazoalkane ratios. This leads to incomplete insertion onto desired compounds. Herein, and decay kinetics diazoalkanes evaluated from TPDs various electron drawing groups, including 3-Phenyl-3-(trifluoromethyl)-3H-diazirine (TPD-H), p-benzyl alcohol...
Bone fractures are in need of rapid fixation methods, but the current strategies limited to metal pins and screws, which necessitate secondary surgeries upon removal. New techniques sought avoid surgical revisions, while maintaining or improving speed. Herein, a method bone is proposed with transparent biopolymers anchored place via light-activated biocomposites based on expanding CaproGlu bioadhesives. The serve as UV light guide for activation biocomposites, results evolution molecular...