A5091260231- Glycosylation and Glycoproteins Research
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Diet and metabolism studies
- Veterinary Oncology Research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Malaria Research and Control
- Prosthetics and Rehabilitation Robotics
- Polymer Surface Interaction Studies
- Mitochondrial Function and Pathology
- Infectious Diseases and Mycology
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Electrospun Nanofibers in Biomedical Applications
- Climate Change and Health Impacts
- Lipid metabolism and biosynthesis
- Tumors and Oncological Cases
- Mosquito-borne diseases and control
- interferon and immune responses
- Reproductive Physiology in Livestock
- Influenza Virus Research Studies
- Reconstructive Facial Surgery Techniques
Agency for Science, Technology and Research
2017-2022
Institute of Molecular and Cell Biology
2017-2022
Advanced Digital Sciences Center
2017
Michigan State University
2014
Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They orchestrators of chronic obstructive pulmonary disease (COPD), with their number significantly increased functions altered in COPD. However, it is unclear how AM function controlled a healthy if changes AMs without environmental assault sufficient to trigger inflammation We report here that absence isthmin 1 (ISM1) mice (Ism1-/- ) leads increase both functional heterogeneity, enduring inflammation,...
Malaria-associated acute respiratory distress syndrome (ARDS) and lung injury (ALI) are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms that lead to complications, such as vascular leakage, remain unclear. Here, we confirm depleting CD8+T cells with anti-CD8β antibodies in C57BL/6 mice infected P. berghei ANKA (PbA) prevent pulmonary leakage. When transfer activated parasite-specific into PbA-infected TCRβ-/- (devoid all T-cell populations), leakage...
Mouse models have contributed to the bulk of knowledge on Systemic Lupus Erythematosus (SLE). Nevertheless, substantial differences exist between human and mouse immune system. We aimed establish characterise a SLE model mediated by Injection pristane into immunodeficient mice reconstituted with system (humanised mice) recapitulated key features, including: production anti-nuclear autoantibodies, lupus nephritis, pulmonary serositis. There was reduction in number lymphocytes peripheral...
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Here we demonstrate the potential of multispectral optoacoustic tomography (MSOT), a new non-invasive structural and functional imaging modality, to track growth changes in blood oxygen saturation (sO
Abstract PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity fate determination, often dysregulated cancer. The PRDM15 gene is of particular interest, given its low expression adult tissues overexpression B-cell lymphomas. Despite well characterized role stem biology during early development, the cancer remains obscure. Herein, we demonstrate that while largely dispensable for mouse somatic homeostasis...
A catheter-based device activates voltage-curable adhesives in situ for minimally invasive closure of vascular lumen defects.
Abstract SUGCT ( C7orf10 ) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied vivo. Although mutations Sugct lead to Glutaric Aciduria Type 3 disease humans, patients remain largely asymptomatic despite high levels of the urine. To study mechanism, we generated SugctKO mice uncovered imbalanced lipid acylcarnitine metabolism kidney addition changes gut microbiome. After were treated with antibiotics,...
Driven by the clinical need for a strong tissue adhesive with elastomeric material properties, departure from legacy crosslinking chemistries was sought as multipurpose platform mending. A fresh approach to bonding wet substrates has yielded synthetic biomaterial that overcomes drawbacks of free-radical and nature-inspired bioadhesives. food-grade liquid polycaprolactone grafted carbene precursors yields CaproGlu. The first-of-its-kind low-viscosity prepolymer is VOC-free requires no...
Cell cycle progression and lipid metabolism are well-coordinated processes required for proper cell proliferation. In liver diseases that arise from dysregulated metabolism, hepatocyte proliferation is diminished. To study the outcome of CDK1 loss blocked on consequent impact whole-body physiology, we performed lipidomics, metabolomics, RNA-seq analyses a mouse model. We observed reduced triacylglycerides in young mice, caused by oxidative stress activated FOXO1 to promote expression Pnpla2...
Iodine excess and resultant hyperplastic goiter are well documented in neonatal ruminants, but little is reported on iodine adult ruminants associated histological changes of the thyroid gland. Two Holstein cows from a Michigan dairy herd that had lost several other animals nonspecific clinical signs illness were submitted for necropsy. Thyroid glands one these 2 grossly markedly enlarged, histologically, both regions cystic nodular hyperplasia follicular atrophy. elevated concentrations....
The highly pathogenic avian influenza A (H5N6) virus has caused sporadic human infections with a high case fatality rate. Due to the continuous evolution of this subtype and its ability transmit humans, there is an urgent need develop effective antiviral therapeutics. In study, murine monoclonal antibody 9F4 was shown display broad binding affinity against H5Nx viruses. Furthermore, can neutralize H5N6 pseudotyped particles prevent entry into host cells. Additionally, ADCC/ADCP deficient...
Macrophages are an important leukocyte component of the microenvironment neoplasms. have classically been subdivided into M1 and M2, depending on their roles in immune response, wound healing, promotion or inhibition tumor growth. In human breast cancer, increased presence M2 macrophages has associated with poor prognosis. The authors hypothesized that rat mammary carcinomas macrophage influx compared to benign proliferative lesions normal glands as well. humans, both express CD68, while...
Forceps, clamps, and haemostats are essential surgical tools required for all interventions. While they widely used to grasp, hold, manipulate soft tissue, their metallic rigid structure may cause tissue damage due the potential risk of applying excessive gripping forces. Soft pneumatic grippers fabricated by silicone elastomeric materials with low Young's modulus offer a promising solution minimize this unintentional inherent excellent compliance compressibility. The goal work is evaluate...
An 8-year-old 40.5-kg (89.1-lb) neutered male Mastiff X pit bull-type dog with a history of joint problems and suspected torn cranial cruciate ligament had sudden onset anorexia, started vomiting bile water, died day after these signs.In view the fact that this dog' s death occurred shortly recent party in house, client could have gained access to potentially toxic substances during event. Gross FindingsOn gross examination, was good nutritional status (body condition score, 6/9) but...