A5032384353- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Pancreatic function and diabetes
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Polyamine Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Prenatal Substance Exposure Effects
- Genomics and Chromatin Dynamics
- Amino Acid Enzymes and Metabolism
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
Agency for Science, Technology and Research
2020-2022
Institute of Molecular and Cell Biology
2020-2022
University of Bologna
2017-2021
Abstract PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity fate determination, often dysregulated cancer. The PRDM15 gene is of particular interest, given its low expression adult tissues overexpression B-cell lymphomas. Despite well characterized role stem biology during early development, the cancer remains obscure. Herein, we demonstrate that while largely dispensable for mouse somatic homeostasis...
Abstract Deregulation of MYC is among the most frequent oncogenic drivers in hepatocellular carcinoma (HCC). Unfortunately, clinical success MYC‐targeted therapies limited. Synthetic lethality offers an alternative therapeutic strategy by leveraging on vulnerabilities tumors with deregulation. While several synthetic lethal targets have been identified HCC, need to prioritize greatest potential has unmet. Here, we demonstrate that pairing splice‐switch oligonucleotide (SSO) technologies our...
Ornithine decarboxylase (ODC1), a critical regulatory enzyme in polyamine biosynthesis, is direct transcriptional target of MYCN, amplification which powerful marker aggressive neuroblastoma. A single nucleotide polymorphism (SNP), G316A, within the first intron ODC1, results genotypes wildtype GG, and variants AG/AA. CRISPR-cas9 technology was used to investigate effects AG clones from MYCN-amplified SK-N-BE(2)-C cells effect SNP on MYCN binding, promoter activity investigated using EMSA...