A5066489034- Anatomy and Medical Technology
- Surgical Simulation and Training
- Synthesis and Catalytic Reactions
- Foot and Ankle Surgery
- Chemical Synthesis and Analysis
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Shoulder and Clavicle Injuries
- Neuroscience and Neuropharmacology Research
- Synthesis of β-Lactam Compounds
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Lower Extremity Biomechanics and Pathologies
- Spine and Intervertebral Disc Pathology
- Asymmetric Hydrogenation and Catalysis
- Bone Tumor Diagnosis and Treatments
- Neuroendocrine regulation and behavior
- Tendon Structure and Treatment
- Nerve Injury and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Cyclopropane Reaction Mechanisms
- Medical Imaging and Analysis
Istituto Ortopedico Rizzoli
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
GlaxoSmithKline (Italy)
2001-2011
GlaxoSmithKline (United Kingdom)
2002-2007
University of Bologna
1991-1998
This paper presents the application of a low-cost 3D printing technology in pre-operative planning and intra-operative decision-making. Starting from Computed Tomography (CT) scans, we were able to reconstruct model area interest with very simple rapid workflow, using open-source software an entry level printer. The use High Temperature Poly-Lactic Acid (HTPLA) by ProtoPasta allowed fabricating sterilizable models, which could be used within surgical field. We believe that our method is...
[1,5]Benzothiazepines are widely used in a number of different therapeutic areas and therefore represent an interesting scaffold for de novo exploration. Recent literature reports suggest their value as antibacterial agents. The present paper the exploration this generation combinatorial libraries both solution on solid phase.
The introduction of aminic nitrogen in organic molecules has been achieved many different ways, one the most popular being use imines. main disadvantage these starting materials lies difficulty synthesising and using imines ammonia, due to their instability, which results tendency trimerize, giving corresponding triazine. Recently a new class imines, N-metalloimines, stable form elusive found very useful applications synthesis nitrogen-containing compounds. This review will cover syntheses...
This work aims to present an in-house low-cost computer-aided simulation (CASS) process that was recently implemented in the preoperative planning of complex osteotomies for limb deformities children. Five patients admitted Unit Paediatric Orthopaedics and Traumatology from April 2018 December 2019, correcting congenital or post-traumatic were included study. Three-dimensional (3D) digital models generated Computed Tomography (CT) scans, using free open-source software, surgery planned...
Three-dimensional printed custom cutting guides (CCGs) are becoming more and investigated in medical literature, as a patient-specific approach is often desired very much needed today’s surgical practice. printing applications computer-aided simulations (CASS) allow for meticulous preoperatory planning substantial reductions of operating time risk human error. However, several limitations seem to slow the large-scale adoption 3D CCGs. CAD designing skills inevitably develop workflow address...
(2S)-2-Methoxycyclohexanone [(2S)-6], reacts with the 4-acetoxyazetidinone 3a in presence of SnCl4 and a tertiary amine base (such as N,N-diisopropylethylamine) to give ketoazetidinone 5 (a key intermediate synthesis broad-spectrum antibiotic sanfetrinem 2a) high yield diastereoselectivity. Low-temperature NMR studies reaction indicated formation 1:1 chelate complex 11 between (2S)-6 which, on addition is transformed into highly reactive chelated tin enolate 12. The compound has been...
Background: Neglected fractures of the lateral humeral condyle (LHC) are misdiagnosed or insufficiently treated fractures, presenting later than 3 weeks after injury. The management neglected LHC in children remains controversial. Methods: Twenty-seven were included this retrospective study. Charts and medical records investigated for demographics, time interval between injury treatment, type treatment. Baseline radiographs assessed fracture grading displacement. Final bone healing,...
Improvements in software for image analysis have enabled advances both medical and engineering industries, including the use of tools to recreate internal parts human body accurately. A research found that FDM-sourced elements shown viability a customized reliable approach orthopedics field. Three-dimensional printing has allowed enhanced accuracy preoperative planning, leading reduced surgery times, fewer unnecessary tissue perforations, healing complications. Furthermore, using custom...
Abstract Background The management of painful rigid flatfoot (RFF) with talocalcaneal coalition (TCC) is controversial. We aimed to compare operative and nonoperative treatment in children RFF TCC. Methods retrospectively reviewed medical records radiographs TTC treated between 2005 2015. consisted manipulation under anesthesia, cast immobilization shoe insert after removal. combined TCC resection, graft interposition subtalar arthroereisis. Results Thirty-four (47 ft) the group twenty-one...
Patellar instability is the most common disorder of knee during childhood and adolescence. Surgical treatment significantly reduces rate redislocation, but underlying pathologies pattern may affect results. We aimed to report clinical functional outcomes three-in-one procedure for patellar realignment in a cohort skeletally immature patients with or without syndromes various patterns chronic instability. retrospectively investigated 126 (168 knees) affected by idiopathic syndromic...
Osteoporotic vertebral fractures represent a constantly increasing pathology that may compromise life quality and general health. Among various treatment options, percutaneous vertebroplasty has been used widely over the past 20 years. Although there is vast amount of retrospective reports in literature, high-level evidence emerged only recently. In this paper, authors provide synopsis current literature on efficacy safety while also presenting step-by-step description surgical procedure,...
Abstract Two new classes of potent and selective CRF 1 receptor antagonists are presented. Exploration general templates 3 4 through modifications the top amine bottom phenyl substituents led to optimization in vitro affinity pharmacokinetic profiles. The typical alkyl chains present region were replaced by substituted heteroaryl moieties, leading a dramatic improvement metabolic stability. This was apparent when compounds dosed vivo: several exhibited low plasma clearance, good oral...
Potent and selective CRF1 receptor antagonists based on the 5,6-dihydro-1H-pyrrolo[2,3-d]pyrimidines 2 were discovered characterized. Identification of two complementary synthetic pathways allowed an efficient SAR exploration, which was facilitated by computational methods that rational design target compounds within a defined drug-like physicochemical space.