A5016768426- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Water Treatment and Disinfection
- Microplastics and Plastic Pollution
- Atmospheric chemistry and aerosols
- Nutritional Studies and Diet
- Per- and polyfluoroalkyl substances research
- Microbial bioremediation and biosurfactants
- Healthcare and Environmental Waste Management
- Metabolomics and Mass Spectrometry Studies
- Carcinogens and Genotoxicity Assessment
- Marine and coastal ecosystems
- Computational Drug Discovery Methods
- Environmental Toxicology and Ecotoxicology
- COVID-19 impact on air quality
- Wastewater Treatment and Reuse
- Pesticide and Herbicide Environmental Studies
- Nanoparticles: synthesis and applications
- Mercury impact and mitigation studies
- Atmospheric Ozone and Climate
- Reliability and Maintenance Optimization
- Marine Bivalve and Aquaculture Studies
- Indoor Air Quality and Microbial Exposure
Nanyang Technological University
2018-2023
Peking University
2013-2014
Jilin University
2011
BACKGROUND: Due to the ubiquitous use of chemicals in modern society, humans are increasingly exposed thousands that contribute a major portion human exposome.Should comprehensive and risk-based exposome database be created, it would conducive rapid progress exposomics research.In addition, once xenobiotic is biotransformed with distinct half-lives upon exposure, monitoring parent compounds alone may not reflect actual exposure.To address these questions, risk-prioritized needed.OBJECTIVES:...
Humans are constantly being exposed to various xenobiotics at relatively low concentrations. To date, limited evidence is available ascertain whether a complex xenobiotic mixture human-relevant levels causes any health effect. Moreover, there no effective method pinpoint the contribution of each chemical toward such an effect.This study aims understand responses cells containing 23 and develop feasible decipher chemical(s) that contribute significantly observed effect.We characterized...
Laser printers emit high levels of nanoparticles (PM0.1) during operation. Although it is well established that toners contain multiple engineered nanomaterials (ENMs), little known about inhalation exposures to these and work practices in printing centers. In this report, we present a comprehensive exposure assessment indoor microenvironments at six commercial centers Singapore, the first such outside United States, using real-time personal stationary monitors, time-integrated...
Human exposure to hundreds of chemicals, a primary component the exposome, has been associated with many diseases. Urinary biomarkers these chemicals are commonly monitored quantify their exposure. However, because low concentrations and great variability in physicochemical properties biomarkers, exposome research limited by low-throughput costly methods. Here, we developed sensitive high-throughput analytical platform (CIL-EXPOSOME) isotopically labeling urinary common functional groups...
Humans are exposed to many xenobiotics simultaneously, but little is known about the toxic effects based on chemical-chemical interactions. This study aims at evaluating binary interactions between 13 common environmental organic compounds (resulting in 78 pairs) by observing their cytotoxicity HepG2 cells. Among all of tested pairs, combination flame-retardant triphenyl phosphate (TPP) and tris(1,3-dichloro-2-propyl)phosphate (TDCPP) exhibited one most significant synergistic effects. We...
Bisphenol analogs (BPs) are widely used as industrial alternatives for A (BPA). Their toxicity assessment in humans has mainly focused on estrogenic activity, while other effects and mechanisms resulting from BPs exposure remain unclear. In this study, we investigated the of three (Bisphenol AF (BPAF), G (BPG) PH (BPPH)) metabolic pathways HepG2 cells. Results comprehensive cellular bioenergetics analysis nontarget metabolomics indicated that most important process affected by was energy...
Halogenated BPA (XBPA) forms resulting from water chlorination can lead to increased toxicity and different biological effects. While previous studies have reported the occurrence of XBPAs, analytical limitation hindered analysis differentiation many potential isomeric forms. Using online solid-phase extraction - liquid chromatography ion-mobility high-resolution mass spectrometry (OSPE-LC-IM-HRMS), we demonstrated a rapid method for XBPA after chlorination, with total time less than 10 min...
Exposure to organic contaminants in house dust is linked the development or exacerbation of many allergic and immune disorders. In this work, we evaluate effects on different cell bioenergetics endpoints using five lines (16HBE14o-, NuLi-1, A549, THP-1 HepG2), examine its lung epithelial cells conventional 2D 3D (air–liquid interface/ALI) models. Proposed rapid bioenergetic assays relies a quick, 40 min, exposure protocol that provides equivalent dose–response curves for ATP production,...