A5084983294- Enzyme function and inhibition
- Synthesis and biological activity
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Mast cells and histamine
- Cancer Mechanisms and Therapy
Ministry of Education of the People's Republic of China
2024
Zhengzhou University
2024
Gastric cancer (GC) is a highly heterogeneous disease, and the response of patients to clinical treatment varies substantially. There no satisfactory strategy for predicting curative effects date. We aimed explore new method efficacy GC based on immune variables detected via flow cytometry. collected 394 tumour tissues from cytometry analysis gating tumour-infiltrating cells (TIICs). Unsupervised consensus clusters were generated cohort classify into different phenogroups, their...
Given the malignancy of gastric cancer, developing highly effective and low-toxic targeted drugs is essential to prolong patient survival improve outcomes. In this study, we conducted structural optimizations based on benzimidazole scaffold. Notably, compound 8 f presented most potent antiproliferative activity in MGC803 cells induced cell cycle arrest at G0/G1 phase. Further mechanistic studies demonstrated that caused apoptosis by elevating intracellular reactive oxygen species (ROS)...
LSD1 (histone lysine-specific demethylase 1) has been gradually disclosed to act as an immunomodulator enhance antitumor immune response. Despite the identification of numerous potent inhibitors, there remains a lack inhibitors approved for marketing. Novel with different mechanisms are therefore needed. Herein, we reported series novel quinazoline-based inhibitors. Among them, compound Z-1 exhibited best inhibitory activity (IC