A5101600204- Lung Cancer Treatments and Mutations
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Cytomegalovirus and herpesvirus research
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Lymphoma Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Cell death mechanisms and regulation
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
- Bone Tumor Diagnosis and Treatments
- Climate Change and Health Impacts
- Tumors and Oncological Cases
- Pneumonia and Respiratory Infections
- Click Chemistry and Applications
- Drug Transport and Resistance Mechanisms
- Silk-based biomaterials and applications
- Tendon Structure and Treatment
- Congenital Diaphragmatic Hernia Studies
- Nonmelanoma Skin Cancer Studies
General Hospital of Shenyang Military Region
2022-2024
Union Hospital
2016-2024
Huazhong University of Science and Technology
2016-2024
Jilin University
2024
Zhejiang Chinese Medical University
2024
Second Hospital of Anhui Medical University
2022-2023
Anhui Medical University
2022-2023
Zhengzhou University
2022
Henan Cancer Hospital
2022
Zhongda Hospital Southeast University
2022
N6 -methyladenosine (m6A) is one of the most abundant internal RNA modifications. We investigated role m6A-modified circRERE in osteoarthritis (OA) and its mechanism.CircRERE IRF2BPL were screened by microarrays. The m6A-modification was examined methylated precipitation morpholino oligo (MOs) treatment. axis circRERE/miR-195-5p/IRF2BPL/β-catenin determined using flow cytometry, western blotting immunofluorescence human chondrocytes (HCs) corroborated a mouse model destabilization medial...
Rearranged during transfection (RET) rearrangement has been identified as one of the crucial oncogenic drivers in non-small cell lung cancer (NSCLC). Recently, two highly selective RET inhibitors have approved by US Food and Drug Administration demonstrated remarkable responses. However, clinical characteristics, outcomes optimal diagnostic method RET-rearrangements are not well understood. This study sought to evaluate prevalence characteristics rearrangement, identify an effective for it,...
Gastric cancer (GC) is a highly heterogeneous disease, and the response of patients to clinical treatment varies substantially. There no satisfactory strategy for predicting curative effects date. We aimed explore new method efficacy GC based on immune variables detected via flow cytometry. collected 394 tumour tissues from cytometry analysis gating tumour-infiltrating cells (TIICs). Unsupervised consensus clusters were generated cohort classify into different phenogroups, their...
Ovarian cancer (OC) is one of the most prevalent malignant tumors affecting women's life and health.Since OC has a poor prognosis due to extensive metastasis, there need explore new mechanism metastasis.microRNAs (miRs) are single-stranded, non-coding RNAs.miR-9 been reported promote may provide strategy for diagnosis.The purpose this study was examine function underlying miR-9 in OC.RT-qPCR used assess expression levels.Transwell assays were determine number migrating invading cells.The...
Published studies reported that loss of function the p15(INK4B) gene is caused by hypermethylation; however, whether or not inactivation associated with incidence and clinical significance multiple myeloma (MM) remains unclear. In this study, we performed a meta-analysis to quantitatively determine effects p15 hypermethylation on MM. The related research articles in English Chinese languages were evaluated. data extracted assessed independently. pooled analyzed odds ratios calculated...
Abstract Background The anteroposterior view of the lumbar plain radiograph (AP-LPR) was chosen as original and first radiographic tool to determine classify lumbosacral transitional vertebra with morphological abnormality (MA-LSTV) according Castellvi classification. However, recent studies found that AP-LPR might not be sufficient detect or MA-LSTV correctly. present study aims verify reliability on detecting classifying types, taking coronal reconstructed CT images (CT-CRIs) gold...
Background: Although poly (ADP-ribose) polymerase family member 10 (PARP10) has been implicated in the progression of multiple cancer types, its role oral squamous cell carcinoma (OSCC) remains unknown. This study aimed to examine function PARP10 OSCC and investigate underlying mechanisms. Methods: The expression was investigated patient cohorts. Kaplan-Meier curve analysis performed assess association between prognosis OSCC. Correlation related variables analyzed by χ 2 test. CKK-8,...
Introduction Transformation from lung adenocarcinoma (LUAD) to small cell cancer (SCLC) is one of the mechanisms responsible for acquired EGFR-TKIs resistance. Although it rarely happens this event determines a rapid disease deterioration and needs specific treatment. Patient method We report case 75-year-old LUAD female with p.L858R mutation in Epidermal Growth Factor Receptor (EGFR) who presented SCLC transformation after responding first line osimertinib treatment only 6 months. To...
Lung cancer has the highest mortality rate among cancers worldwide, and most patients are diagnosed with non-small-cell lung (NSCLC), evaluating clinical efficacy of molecularly targeted therapy remains a major challenge.This paper retrospectively investigated outcome information 291 detected by next-generation sequencing (NGS) analysis fluorescence in situ hybridization (FISH), including 63 who were followed up. We analyzed epidermal growth factor receptor (EGFR) mutation abundance...
The aim of this study was to determine the differences in characteristics Mycoplasma pneumoniae pneumonia (MPP) children with and without asthma inhaled corticosteroid (ICS) therapy order risk factors for exacerbation effect regular ICS on MPP.Children MPP were divided into two groups according whether they had a history asthma. Children further an group therapy. clinical characteristics, laboratory test results, pulmonary images compared between Differences severity acute groups....
Quercetin (QCT) is a bioflavonoid derived from vegetables and fruits that has anti-inflammatory anti-ferroptosis effects against various diseases. Previous studies have shown QCT modulates the production of cellular inflammatory factors in asthma models delays development chronic airway inflammation. However, regulatory mechanism QCT, traditional Chinese medicine, treatment not been elucidated. The aim present study to investigate whether can inhibit ferroptosis via SIRT1/Nrf2 pathway play...
Background Asthma is the most common chronic pulmonary disease in children. MicroRNAs (miRNAs) play a regulatory role occurrence and development of asthma. We aimed to explore differential expression miRNAs peripheral blood children with asthma identify miRNA that can alleviate inflammation.
High temperature and hot sun environments are prevalent in many situations.The extreme have put forward a severe challenge to the health safety of outdoor workers.However, people duty booth still stick their post guarantee social normal production living activities.In this paper, security guards tower crane workers selected as research objects.In order study effects partial cooling, physiological responses three conditions including head limbs cooling no compared.The shows that can reduce...