A5086469680- Immunotoxicology and immune responses
- Veterinary Oncology Research
- Animal testing and alternatives
- Dermatological diseases and infestations
- Essential Oils and Antimicrobial Activity
- Acne and Rosacea Treatments and Effects
- Growth Hormone and Insulin-like Growth Factors
- Congenital gastrointestinal and neural anomalies
- Biological Research and Disease Studies
- Thyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Fungal Infections and Studies
- Gene expression and cancer classification
- Poxvirus research and outbreaks
- Carcinogens and Genotoxicity Assessment
- Neurogenesis and neuroplasticity mechanisms
- Animal Genetics and Reproduction
- Glioma Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Hedgehog Signaling Pathway Studies
- Complement system in diseases
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Craniofacial Disorders and Treatments
- Genetic and phenotypic traits in livestock
BASF (Germany)
2020-2024
Justus-Liebig-Universität Gießen
2007-2016
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/inhand.asp ) is a joint initiative the societies toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), North America (STP) to develop an internationally accepted nomenclature proliferative nonproliferative lesions in laboratory animals. purpose this publication provide standardized classifying observed most tissues organs dog used nonclinical safety...
The European Society of Toxicologic Pathology organized an expert workshop in May 2018 to address adversity considerations related thyroid follicular cell hypertrophy and/or hyperplasia (FCHH), which is a common finding nonclinical toxicity studies that can have important implications for risk assessment pharmaceuticals, food additives, and environmental chemicals. broad goal the was facilitate better alignment toxicologic pathology regulatory sciences on how determine FCHH. Key objectives...
The thyroid hormones (THs) regulate various physiological mechanisms in mammals, such as cellular metabolism, cell structure, and membrane transport. therapeutic drugs propylthiouracil (PTU) phenytoin are known to induce hypothyroidism decrease blood hormone levels. To analyze the impact of these two on systemic we focused metabolic changes after treatment. Therefore, a rat model, metabolome liver tissue well from plasma, 2-week 4-week administration following recovery phase, was...
In humans, rodents and horses, pigmentary anomalies in combination with other disorders, notably intestinal aganglionosis, are associated variants of the endothelin type-B receptor gene (EDNRB). an inbred Cameroon sheep flock, five white lambs light blue eyes were sired from same ram died within a few hours up to days after birth, some them signs obstruction. The aim this study was investigate if observed hypopigmentation possible lethal condition molecular change at ovine EDNRB locus, check...
Multi-omics data integration has been repeatedly discussed as the way forward to more comprehensively cover molecular responses of cells or organisms chemical exposure in systems toxicology and regulatory risk assessment. In Canzler et al. (Arch Toxicol 94(2):371-388. https://doi.org/10.1007/s00204-020-02656-y ), we reviewed state art applying multi-omics approaches toxicological research We developed best practices for experimental design studies, omics acquisition, subsequent integration....
Central neurocytoma is a rare, prognostically favorable neuronal tumor of the human central nervous system, typically located intraventricularly near foramen Monro. Extraventricular cerebral neurocytomas and spinal tumors have also been reported. To date, however, not documented in domestic animal species. In this report, we describe cord dog. The microscopic examination revealed cells forming loosely packed clusters some areas palisades other areas. addition, they showed fine fibrillary...
Anencephaly results from defects in neural tube closure early gestation and, to the authors' knowledge, has not been reported dogs. In this case, canine fetus was stillborn at 62nd day of and had a hypoplastic calvarium, with flattened base skull shallow orbits, causing protrusion eyes. Macroscopically, brain completely missing. Histologically, well-differentiated nerve fibers, fragments cerebellar folia, ganglia large neurons glial cells were detected loose stroma sections through cranial...
Summary A 3‐year‐old neutered male British shorthair cat was presented to the Clinic for Small Animal Medicine, Internal Medicine and Clinical Pathology, at Justus‐Liebig‐University Giessen with a short history of lethargy, severe dyspnoea, fever, anaemia, thrombocytopenia hyperbilirubinaemia. In blood smears lymph node aspirates, large pleomorphic lymphatic blasts were detected. On necropsy splenic infarcts moderate hydrothorax as well ascites could be observed. Histological examination...
Zusammenfassung Gegenstand und Ziel: Der Fallbericht geht auf die klinischen pathologischen Befunde bei einem Pferd ein, das an Adenokarzinom des Pankreas erkrankt war. Material Methoden: Ein 17 Jahre alter Warmblutwallach wies seit 2 Wochen Diarrhö, Gewichtsverlust erhöhte Leberwerte im Serum auf. Er wurde in der Klinik vorgestellt, als zusätzlich Fieber auftrat. Nach klinischer, labordiagnostischer sonographischer Untersuchung erfolgte eine symptomatische Behandlung. Ergebnisse: Das...
Zusammenfassung Gegenstand und Ziel: der vorliegenden Untersuchung war Nachweis von MHC-II-Antigenen auf den verschiedenen Zellen Haut bei Hunden mit Demodikose. MHC-IIProteine spielen eine zentrale Rolle zellvermittelten Immunantwort. Sie präsentieren Fragmente extrazellulär auftretendem Antigen, um Immunreaktion auszulösen. Material Methoden: Als dienten 15 Hautbiopsien Hunden, die in Jahren 2003 2004 zur Routinediagnostik an das Institut für Veterinär-Pathologie Justus-Liebig-Universität...
Zusammenfassung: Eine 6-jährige Warmblutstute wurde mit dem Verdacht auf eine chronisch obstruktive Bronchitis in der Gießener Klinik vorgestellt, da sie trotz staubarmer Haltung und Glukokortikoidgaben zunehmend Husten zeigte.Mittels Bronchoskopie ließ sich Zubildung im rechten Hauptbronchus darstellen.Bei radiologischen Untersuchung Lunge zeigten multiple, fokale Verschattungen gesamten Lungenfeld.Bei pathologisch-anatomischen wurden ausschließlich bis zu 40 mm Durchmesser große, weiße,...