A5042799915- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Immunotoxicology and immune responses
- Viral-associated cancers and disorders
- Reproductive Physiology in Livestock
- Animal health and immunology
- Oral and Maxillofacial Pathology
- Bacillus and Francisella bacterial research
- Retinal Development and Disorders
- Cardiac Arrhythmias and Treatments
- Congenital Anomalies and Fetal Surgery
- Statistical Methods in Clinical Trials
- Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Advanced Fluorescence Microscopy Techniques
- Cytomegalovirus and herpesvirus research
- Cardiac Valve Diseases and Treatments
- Zoonotic diseases and public health
- Mesenchymal stem cell research
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Computational Drug Discovery Methods
- Cardiovascular Conditions and Treatments
Scottsdale Community College
2024
Bristol-Myers Squibb (United States)
2007-2018
Bristol-Myers Squibb (Germany)
2007
Hochschule Hannover
1986
Data collected from 182 marketed and nonmarketed pharmaceuticals demonstrate that there is little value gained in conducting a rat two-year carcinogenicity study for compounds lack: (1) histopathologic risk factors neoplasia chronic toxicology studies, (2) evidence of hormonal perturbation, (3) positive genetic results. Using single result among these three criteria as test outcome the study, fifty-two sixty-six tumorigens were correctly identified, yielding 79% sensitivity. When all...
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/inhand.asp ) is a joint initiative the societies toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), North America (STP) to develop an internationally accepted nomenclature proliferative nonproliferative lesions in laboratory animals. purpose this publication provide standardized classifying observed most tissues organs dog used nonclinical safety...
Summary Morphological and functional aspects of placental maturation mechanisms in the cow 1. Light microscopical findings The criteria bovine placentone maturation, which can be evaluated by light microscopy, are illustrated progress these proceedings maternal crypts shown. A missing or a disturbed is considerable pathogenetic importance for occurrence retained placenta. How far other factors, especially leucocytes, directly responsible physiological separation placenta discussed...
BMS-645737, an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast (FGF) receptor-1, has anti-angiogenic activity was evaluated in nonclinical studies as a treatment for cancer. This article characterizes the BMS-645737-induced clinical, gross, histologic lesions incisor teeth Sprague-Dawley (SD) rats. Rats received 0 800 mg/kg BMS-645737 single-dose study or consecutive daily doses 20 mg/kg/day 1-month study. The reversibility these effects assessed White...
Spontaneous findings noted in the eyes of Mauritian cynomolgus monkeys are described and descriptions supplemented with illustrations. Findings observed after extensive histopathologic examinations (20 to 44 sections per eye) from 20 control, 17 treatment-naive stock monkeys, 2 drug-treated that were considered be spontaneous included. Also included 361 control routine toxicity studies performed at our laboratories, for most which a standard histopathological examination 1 section eye was...
The Tumor Combination Guide was created at the request of U. S. Food and Drug Administration (FDA) by a Working Group biopharmaceutical experts from international societies toxicologic pathology, (FDA), members Standard for Exchange Nonclinical Data (SEND) initiative, to assist pharmacology/toxicology reviewers biostatisticians in statistical analysis nonclinical tumor data. guide will also be useful study peer review pathologists interpreting This provides higher-level hierarchy types or...
Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and human fetuses newborns. We observed a high incidence (62 208 animals examined) of spontaneous on the atrioventricular (AV) valves 10– to 40–week-old Sprague-Dawley rats. The was predominately septal cusp right AV located near ostium 57 62 animals. Of remaining 5 valvular angiectases, 2 were present parietal 3 left valve. angiectases single or multiple, ranging from 40 300 um diameter characterized...