A5041834360- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Cardiovascular Conditions and Treatments
- Cardiovascular and Diving-Related Complications
- Nitric Oxide and Endothelin Effects
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Vascular Anomalies and Treatments
- Transplantation: Methods and Outcomes
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Renal and Vascular Pathologies
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Ultrasound in Clinical Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Sinusitis and nasal conditions
The University of Texas Southwestern Medical Center
2016-2025
Children's Medical Center
1995-2024
Southwestern Medical Center
2020-2024
Pediatrics and Genetics
2020
C. S. Mott Children's Hospital
2017
University of Iowa Stead Family Children’s Hospital
2017
Cincinnati Children's Hospital Medical Center
2017
Children's Hospital of Philadelphia
2017
University of Utah
2017
Adult Congenital Heart Association
2017
Persistent pulmonary hypertension of the newborn causes systemic arterial hypoxemia because increased vascular resistance and right-to-left shunting deoxygenated blood. Inhaled nitric oxide decreases in newborns. We studied whether inhaled severe infants with persistent hypertension.
Background Angiotensin-converting enzyme inhibitors improve exercise capacity in adults with congestive heart failure by decreasing systemic vascular resistance and improving ventricular diastolic function. P atients who have undergone the Fontan procedure decreased cardiac output, increased resistance, abnormal function, compared normal people. Methods Results To test hypothesis that afterload reduction therapy alters hemodynamic variables augments patients after a procedure, we results of...
Abstract Introduction: Since the 1980s, stent implantation has evolved as an important therapeutic strategy for coarctation of aorta. However, available data is frequently flawed by short follow‐up, lack adequate follow‐up imaging, and retrospective nature collection. Methods : Data was prospectively collected using a multicenter registry congenital cardiovascular interventional study consortium (CCISC). Between 2000 2009, 302 patients from 34 centers with median weight 58 kg underwent...
Alterations in endothelium-derived relaxing factor (EDRF) production or mechanism of action may be involved the responses developing pulmonary vasculature to changes oxygenation. In this study effects acute vitro oxygen tension on EDRF were determined isolated segments ovine fetal intrapulmonary arteries (4th generation) obtained at 125-135 days gestation (term 144 +/- 4 days). was assessed by measuring segment guanosine 3',5'-cyclic monophosphate (cGMP) accumulation presence a...
Abstract Background: Procedure duration is an important predictor of patient outcomes in surgery. However, the relationship between procedure and adverse events congenital cardiac catheterization largely unexplored. Methods: All cases entered into Congenital Cardiac Catheterization Project on Outcomes from 2014 to 2017 were included. Cases ordered shortest longest case length, minus time spent managing events, for each type. The outcomes, Level 3bc/4/5 4/5 event rates, calculated above below...
Endothelin-1 causes vasodilation of the intact porcine pulmonary vascular bed. To determine cause this vasodilation, we investigated interactions endothelin-1 (ET-1), endothelium-derived nitric oxide (EDNO), and prostacyclin in isolated small arteries veins under vitro conditions. ET-1 caused concentration-dependent contractions veins, augmented by synthase (NOS) inhibitor, N omega-nitro-L-arginine, veins. BQ-123 (ETA-receptor antagonist) depressed ET-1-induced contractions. Sarafotoxin S6C,...
To investigate whether age and valve size at implant contribute to outcomes after Melody transcatheter pulmonary replacement (TPVR).Patient longevity of surgical valves.All patients discharged with a in the position, as part three prospective multicenter studies, comprised study cohort. Acute time-related were analyzed according age: children (≤12 years), adolescents (13-18 young adults (19-29 older (≥30 years).Successful implantation occurred 49 children, 107 adolescents, 96 adults, 57...
Abstract Background : Balloon angioplasty of bifurcating pulmonary artery (PA) stenoses is often inadequate, and stent treatment requires simultaneous implantation two stents. This study evaluates initial results long‐term follow up transcatheter placement in PAs. Methods a retrospective review patients (pts) who had PA stents placed main lobar branches from 1993 to 2007. Results Forty‐nine pts at median age 10.9 years (range 1–43 years). The mean minimum vessel diameter increased 5.7 ± 2.5...
This study examines factors associated with, and clinical effects of, wire frame fractures (WFF) of the GORE HELEX Septal Occluder (HELEX).Investigator-reported data from every implanted in United States between 4/2000 4/2005 were reviewed. Clinical procedural patients who experienced WFF compared with did not. The echocardiographic fluoroscopic images for reviewed predictors alterations function.With 90% subjects followed >12 months, 19/298 (6.4%) found to have WFF. Thirty WFFs observed,...
Abstract Novel commercially available software has enabled registration of both CT and MRI images to rapidly fuse with X-ray fluoroscopic imaging. We describe our initial experience performing cardiac catheterisations the guidance 3D imaging overlay using VesselNavigator system (Philips Healthcare, Best, NL). A total 33 patients CHD were included in study. Demographic, advanced imaging, catheterisation data collected between 1 December, 2016 31 January, 2019. report successful use this...