A5037231630- Mycotoxins in Agriculture and Food
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Pulmonary Hypertension Research and Treatments
- Climate Change and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Plant Disease Resistance and Genetics
- Nanoparticles: synthesis and applications
- Pharmacological Effects of Natural Compounds
- Hydrogen's biological and therapeutic effects
- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Plant Pathogens and Resistance
- Connexins and lens biology
- Heavy Metal Exposure and Toxicity
- Ion Channels and Receptors
- Selenium in Biological Systems
- Marine Toxins and Detection Methods
- Wheat and Barley Genetics and Pathology
- Insect and Pesticide Research
- Air Quality Monitoring and Forecasting
- Inhalation and Respiratory Drug Delivery
- Energy and Environment Impacts
- Eicosanoids and Hypertension Pharmacology
Inserm
2008-2023
Centre de Recherche Cardio-Thoracique de Bordeaux
2013-2023
Université de Bordeaux
2006-2023
Bordeaux Population Health
2010-2023
Hôpital Xavier Arnozan
2022
GTx (United States)
2000
Click to increase image sizeClick decrease sizeKeywords: Ochratoxin A Beverages Wine Morocco
In intrapulmonary arteries (IPA), endothelial cells (EC) respond to mechanical stimuli by releasing vasoactive factors set the vascular tone. Piezo1, a stretch-activated, calcium-permeable channel, is sensor of stress in EC. The present study was undertaken investigate implication Piezo1 endothelium-dependent regulation IPA tone and potential involvement pulmonary hypertension, main disease this circulation. quantified means myograph control Piezo1+/+ mice lacking (EC-Piezo1-/-). Endothelial...
Because pulmonary circulation is the primary vascular target of inhaled particulate matter (PM), and nitric oxide a major vasculoprotective agent, in this study we investigated effect various particles on NO-cyclic guanosine monophosphate (cGMP) pathway arteries.We used intrapulmonary arteries and/or endothelial cells, either exposed vitro to or removed from PM-instilled animals for assessment vasomotricity, cGMP reactive oxygen species (ROS) levels, cytokine/chemokine release.Endothelial...
Regulations on ambient particulate matter (PM) are becoming more stringent because of adverse health effects arising from PM exposure. PM-induced oxidant production is a key mechanism behind the observed and heavily dependent composition. Measurement intrinsic oxidative potential (OP) could provide an integrated indicator bioreactivity serve as better metric hazard exposure than mass concentration. The OP two chemically contrasted PM2.5 samples was compared through four acellular assays,...
In intrapulmonary arteries (IPAs), mechanical forces due to blood flow control vessel tone, and these change during pulmonary hypertension (PH). Piezo1, a stretch-activated calcium channel, is sensor of stress present in both endothelial cells (ECs) smooth muscle (SMCs). The study investigated the role Piezo1 on IPA chronic hypoxia model PH. Rats were raised chronically hypoxic conditions for 1 (1W-CH, early stage) or 3 weeks (3W-CH, late-stage) PH normoxic (Nx). Immunofluorescence labeling...
Available epidemiological information seems to indicate that Balkan endemic nephropathy is associated with consumption patterns involving foodstuffs contaminated ochratoxin A (OTA) and a higher frequency of OTA-positive blood samples. The aim this preliminary study was assess OTA concentrations in human plasma Morocco. Therefore, samples from 309 healthy volunteers (213 males, 96 females) were analysed. analyses revealed 60% the sampled positive for (61.5% male 56% female population), an...
Cases of karyomegaly were described by Sclare 30 and Mihatch 31 in patients affected with tubular-interstitial nephropathy. The Karyomegalic cells showed enlarged nuclei accumulation genetic material. No aetiology was suggested. Our study rats experimentally intoxicated ochratoxin A, a well-known nephrotoxic compound, indicates the presence alteration tubular tissue. In control animals no karyomegalic detected. These observations suggest that megacytosis may be caused A kidney. addition...
Abstract Abnormal Savda Munziq (ASMq) is a traditional Uighur medicinal herbal preparation commonly used to treat diseases such as diabetes, cardiovascular diseases, chronic asthma and especially digestive cancer. Earlier studies have shown that ASMq free radical scavenger could prevent mitochondrial DNA oxidative damage. In this study, we tested the effects of aqueous extract on human hepatoma cells (HepG2) explore possible mechanism its putative anticancer properties. Aqueous was HepG2...
In New Caledonia, anthropic activities, such as mining, increase the natural erosion of soils in nickel mines, which turn, releases oxide nanoparticles (NiONPs) into atmosphere. Pulmonary vascular endothelial cells represent one primary targets for inhaled nanoparticles. The objective this vitro study was to assess cytotoxic effects NiONPs on human pulmonary artery (HPAEC). Special attention will be given level oxidative stress and calcium signaling, are involved physiopathology...