A5027817271- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Glycosylation and Glycoproteins Research
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Reactions
- Diet, Metabolism, and Disease
- Asymmetric Hydrogenation and Catalysis
- Synthesis of Organic Compounds
- Synthesis and Catalytic Reactions
- Metal complexes synthesis and properties
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Click Chemistry and Applications
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Nanomaterials for catalytic reactions
- Inorganic and Organometallic Chemistry
- Crystallography and molecular interactions
- Marine Sponges and Natural Products
- Fluorine in Organic Chemistry
- Amino Acid Enzymes and Metabolism
- Multicomponent Synthesis of Heterocycles
Universidad de Oviedo
2013-2025
University of Almería
2017-2024
University of Aveiro
2012-2018
Universidade de Santiago de Compostela
2003-2014
Center for Research in Molecular Medicine and Chronic Diseases
2011-2013
University of Oxford
2004-2012
Universidade da Coruña
2006-2011
Mansfield University
2004-2006
Lipids are one of the primary metabolites microalgae and cyanobacteria, which enrich their utility in pharmaceutical, feed, cosmetic, chemistry sectors. This work describes isolation, structural elucidation, antibiotic antibiofilm activities diverse lipids produced by different cyanobacteria strains from two European collections (ACOI LEGE-CC). Three strain were selected for antibacterial and/or activity after screening about 600 carried out under NoMorFilm project. The total organic...
We describe the preparation and characterization of novel Au( iii ) cyclometallated κ 1 S-azoli(ni)um-2-dithiocarboxylatecomplexes their rearrangement to biscyclometallated 2 -S,S′-azoli(ni)um-2-(methoxy)methanedithiolate complexes.
Introduction/Objectives: Nosocomial infections caused by S. aureus and epidermidis resistant strains are an important cause of morbidity mortality worldwide. Due to the increasing rate resistance conventional antibiotics, discovery new antibiotic drugs is crucial keep pace with evolution these pathogenic bacterial species. Methods: The 3-nitro-2H-chromene moiety present in several compounds potent antibacterial activity; based on previous studies, we report herein synthesis 20...
This study describes the development of a novel liposomal formulation incorporating 3-O-ethyl-L-ascorbic acid (EAA), derivative vitamin C. The EAA-loaded liposomes were fully characterized, particle size and zeta potential values suitable for drug delivery. skin penetration studies revealed that enhanced EAA retention in compared to free EAA. Additionally, impact topical treatments with on photo-aging markers explants was investigated. charged display protective or stimulatory effect...
The cyclopropane motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, due to their strained ring, cyclopropanes possess higher reactivity compared other alkanes, giving access a wide range of transformations. Therefore, the preparation has attracted much attention over past decades. However, increased awareness environmental impact industries laboratories sparked interest synthesis using principles green chemistry. aim this review...
Chromenes represent a biologically significant family of heterocycles, widely present in pharmaceutical compounds and secondary metabolites. Their importance synthesis medicinal chemistry has driven continuous efforts to develop advanced efficient synthetic methodologies. Over the past decade, photoredox catalysis revolutionized Organic Synthesis, offering innovative sustainable strategies for construction functionalization complex molecules. The chromene derivatives greatly benefited from...
The worldwide emergence and spread of infections caused by multidrug-resistant bacteria endangers the efficacy current antibiotics in clinical setting. lack new pipeline points to need developing strategies. Recently, gold-based drugs are being repurposed for antibacterial applications. Among them, gold(III) complexes have received increasing attention as metal-based anticancer agents. However, reports on their activity scarce due stability issues. present work demonstrates complex 2...
The emergence and spread of multidrug-resistant bacteria are a global concern. lack new antibiotics in the pipeline points to need for developing strategies. In this sense, gold(III) complexes (G3Cs) could be promising alternative due their recently described antibacterial activity. aim study was evaluate antimicrobial activity G3Cs alone combination with colistin against pathogenic from veterinary sources. Minimal inhibitory concentration (MIC) values were determined by broth microdilution...
Antimicrobial resistance is a pressing global concern that has led to the search for new antibacterial agents with novel targets or non-traditional approaches. Recently, organogold compounds have emerged as promising class of agents. In this study, we present and characterize (C^S)-cyclometallated Au(III) dithiocarbamate complex potential drug candidate.The was found be stable in presence effective biological reductants, showed potent antibiofilm activity against wide range...
Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in healthy individuals and associated high morbidity immunosuppressed patients, particularly among paediatric population, a specific treatment for this virus has yet to be developed. In study, we report anti-HAdV activity sub-micromolar concentrations four heteroleptic (C^S)-cycloaurated complexes bearing single thiophosphinamide [
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTTotal Synthesis of (−)-DysithiazolamideAna Ardá, Raquel G. Soengas, M. Isabel Nieto, Carlos Jiménez, and Jaime RodríguezView Author Information Departamento de Química Fundamental, Facultade Ciencias, Campus da Zapateira, Universidade Coruña, 15071 A Spain[email protected]; [email protected]Cite this: Org. Lett. 2008, 10, 11, 2175–2178Publication Date (Web):May 7, 2008Publication History Received10 March 2008Published online7 May inissue 5 June...
Four natural lactylates of chlorinated fatty acids, chlorosphaerolactylates A–D (1–4), were isolated from the methanolic extract cyanobacterium Sphaerospermopsis sp. LEGE 00249 through a combination bioassay-guided and MS-guided approaches. Compounds 1–4 are esters (mono-, di-, or tri)chlorinated lauric acid lactic acid, whose structures assigned on basis spectrometric spectroscopic methods inclusive 1D 2D NMR experiments. High-resolution mass-spectrometry data sets also demonstrated...
A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N
Abstract A novel method for the preparation of 2‐nitroalkan‐1‐ols by an indium‐promoted reaction bromonitromethane with a variety aldehydes is reported. The was also performed 2‐bromo‐2‐nitropropanes to afford 2,2‐dialkyl‐2‐nitroalkan‐1‐ols. use chiral sugar‐derived furnished corresponding excellent stereoselectivity. utility 2,2‐dialkyl‐2‐nitroalkan‐1‐ols branched iminosugar derivatives demonstrated hydroxymethyl polyhydroxylated azepane.
An economical method to perform the addition of bromonitroalkanes aldehydes using zinc in presence a catalytic amount indium is established. This procedure affords corresponding nitroalkanols good yields and can be easily scaled up preparative amounts. indium-catalyzed Henry reaction performs better than classic base-catalyzed terms substrate scope avoids use stoichiometric amounts expensive powder.