A5087248948- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Rheumatoid Arthritis Research and Therapies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Hip disorders and treatments
- Bone and Joint Diseases
- Lower Extremity Biomechanics and Pathologies
- Computational Drug Discovery Methods
- Urticaria and Related Conditions
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Advanced Biosensing Techniques and Applications
- Cardiovascular Effects of Exercise
- Nutritional Studies and Diet
- Mathematical Biology Tumor Growth
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
- Traumatic Brain Injury Research
- Lung Cancer Research Studies
- Cerebrospinal fluid and hydrocephalus
- Heparin-Induced Thrombocytopenia and Thrombosis
Aarhus University Hospital
1988-2025
Regionshospitalet Silkeborg
2013-2024
Aarhus University
2016-2024
Zealand University Hospital Køge
2024
Central Denmark Region
2024
University of Copenhagen
1984-2024
Institute of Genetics
1985
Rigshospitalet
1980
Otho S. A. Sprague Memorial Institute
1950
Lurie Children's Hospital
1950
Abstract Purpose 2-[18F]Fluoro-2-deoxy-D-glucose (FDG)–positron emission tomography (PET)/computed (CT) has been suggested as an imaging modality to diagnose polymyalgia rheumatica (PMR). However, the applicability of FDG-PET/CT remains unclear, especially following glucocorticoid administration. This study aimed investigate diagnostic accuracy before and during prednisolone treatment, well short-term discontinuation. Methods Treatment naïve suspected PMR patients were clinically diagnosed...
To develop international consensus-based recommendations for early referral of individuals with suspected polymyalgia rheumatica (PMR).
To identify the risk factors of injuries in handball, 221 players were followed during one indoor season. The injury incidence was 4.6/1000 playing hours and 11.4/1000 game hours. upper extremity involved 41% including 21% finger sprains. Ankle sprains most common (33%), overuse accounted for 18%. reinjury 32%. Contact with opponent running or shooting caused 31% injuries. Errors grasping ball reason Forty percent treated by themselves. After 73% absent from handball more than 1 week....
Approximately half of individuals with suspected polymyalgia rheumatica (PMR) initiate prednisolone before rheumatological evaluation, but it is unknown if reduces the ability to diagnose PMR. This study evaluated clinical assessment a PMR diagnosis and after initiation short-term discontinuation. Data from prospective cohort treatment-naïve patients (n = 66) non-PMR 27) were used create case report forms (CRFs). All assessed at baseline reassessed 8 weeks treatment 57) discontinuation week...
Experimental growth data for three human malignant tumors transplanted to nude mice of BALB/c origin are analyzed statistically in order investigate whether they can be described according the Gompertz function. The aim is set up unequivocal standards planned therapeutic experiments and develop an essential part determination proliferation parameters tumors. results indicate that course tumor with good approximation by A transformation this function depicts rectilinearly appears suitable as...
Abstract Objective The objective was to investigate the incidence of late-onset giant cell arteritis (GCA) within first year in patients diagnosed with polymyalgia rheumatica (PMR). Methods In this prospective study, treatment-naïve individuals a new clinical diagnosis PMR and without GCA symptoms underwent baseline assessments, including vascular ultrasonography 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography computed (FDG-PET/CT). To prevent biased inclusion, rapid referral...
Objective Bone formation is a hallmark of osteoarthritis (OA). It has been speculated that bone may occur because ossification at the bone-cartilage unit, is, directly involving calcified cartilage (CC). This study aimed to investigate thickness CC and subchondral (SCB) in relation severity overlying articular (AC) degeneration. Design We investigated femoral heads from 20 patients with OA 15 healthy subjects design-based stereology using systematic uniform random sampling entire joint...
Specimens from 24 patients with metastatic small cell carcinoma of the lung were explanted in vitro as well transplanted directly into nude mice. A method to obtain fibroblast‐free cultures is described. This resulted lines which could be grown for more than one year 79% cases. Fifty‐four % tumours established serially transplantable The characterized by histology, electron microscopy, DNA index, and cycle distribution. furthermore plating efficiency doubling time. macroscopic growth...
Following the approval of tocilizumab (TCZ) for giant cell arteritis (GCA), recent studies have shown a high relapse frequency after abrupt discontinuation TCZ. However, thorough exploration TCZ tapering compared to has never been undertaken. Likewise, adverse events only scarcely investigated in routine care. This study aimed compare incidence relapses GCA patients undergoing discontinuation.
To investigate bone changes in the metacarpophalangeal (MCP) joints of anti-citrullinated peptide antibody (ACPA)-positive patients with arthralgia, but not arthritis, compared to healthy controls.Using a cross-sectional study design, were recruited from hospitals and private care rheumatologists, controls test subject website. All subjects underwent medical history interview, clinical examination, biochemical screening including ACPA. Patients positive ACPA, no rheumatic disease included....
Abstract Objective In routine care, clinicians may employ 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-PET/CT to validate their initial clinical diagnosis of PMR. Nevertheless, the diagnostic utility combining FDG-PET/CT findings with presentation has not been explored. Therefore, this study aimed investigate whether accuracy for PMR could be enhanced by baseline or 2012 ACR/EULAR classification criteria Methods An investigation and a validation cohort were included from two countries, encompassing...
Dysregulation of the complement system is involved in development age-related macular degeneration (AMD). The cascade regulated by membrane bound regulatory proteins (Cregs) on mononuclear leukocytes among others. This study aims to investigate systemic and Cregs AMD stages their association with treatment response neovascular (nAMD).
A human malignant melanoma transplanted into nude mice was exposed to single-dose X irradiation. Experimental growth data described mathematically according a transformed Gompertz function were used determine the effect of irradiation on delay, rate, and tumor shrinkage. The radiation-induced changes in histology tumors also described. results showed that induced dose-dependent delay; this parameter therefore found suitable for assessment relative therapeutic effect. treatment reduction rate...
Abstract A study was made of the effect ovariectomy, 17β‐oestradiol, and tamoxifen on oestrogen progesterone receptor‐positive T61 human breast carcinoma grown in nude mice. The treatment evaluated by specific growth delay calculated basis Gompertz curves, changes cell cycle distribution monitored flow cytometric DNA analysis. results demonstrated that both oestradiol induced a temporary delay, whereas ovariectomy host had no tumour. oestradiol‐induced tumour accompanied decrease G 1...
Chicago, Illinois From the Children's Memorial Hospital, and Otho S. A. Sprague Laboratory, Chicago
A spontaneous change of cellular DNA content occurred in a hyperdiploid human colonic carcinoma grown nude mice. After the to hyperpentaploidy tumor was exposed single-dose X irradiation, and effects on growth curves cell cycle, determined by flow cytometric analysis (FCM), were compared results obtained with prior evolutionary event. The showed that radiation rate kinetics had changed after content. In hyperpentaploid irradiation no effect regrowth rate, whereas postirradiation decreased....
Journal Article Accepted manuscript Comment on: "Real-world outcomes of a dedicated fast-track polymyalgia rheumatica clinic" Get access Agnete Overgaard Donskov, Donskov Department Rheumatology, Aarhus University Hospital, Central Denmark Region, Aarhus, DenmarkDepartment Clinical Medicine, University, Health, Corresponding author details: Postal address: Palle Juul Jensen Boulevard 59, 8200 N, Denmark. Email agnead@rm.dk https://orcid.org/0000-0002-7909-1624 Search for other works by this...
BACKGROUND: The incidence of colorectal cancer is expected to increase, particularly among patients with significant frailty and comorbidities. A subgroup these may not be suitable for surgery due the high risk postoperative morbidity mortality. OBJECTIVE: aim this study was characterize clinical outcomes, management, social status, survival deemed nonoperable comorbidity and/or frailty. DESIGN: This a retrospective cohort study. SETTINGS: Overall estimated using Kaplan-Meier method. Cox...