A5074204507- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Synthesis and biological activity
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Research on Leishmaniasis Studies
- Nanoparticle-Based Drug Delivery
- Refrigeration and Air Conditioning Technologies
- Drug Solubulity and Delivery Systems
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- Advanced Thermoelectric Materials and Devices
- Chronic Myeloid Leukemia Treatments
- Silk-based biomaterials and applications
- Nanoparticles: synthesis and applications
- Dermatology and Skin Diseases
- Silkworms and Sericulture Research
- Inhalation and Respiratory Drug Delivery
- Plant Pathogens and Fungal Diseases
- Plant Pathogenic Bacteria Studies
- Aerodynamics and Fluid Dynamics Research
- Light effects on plants
Government Medical College
2024
Manipal Academy of Higher Education
2020-2023
Central Sericultural Research and Training Institute
2023
Mahatma Gandhi University
2022
Malabar Cancer Centre
2020
Amrita Institute of Medical Sciences and Research Centre
2018
Amrita Vishwa Vidyapeetham
2018
Banaras Hindu University
2004
In Bihar, India, where visceral leishmaniasis is hyperendemic, amphotericin B deoxycholate now first-line parenteral treatment. To test the efficacy of versus that its lipid formulations, Indian patients were randomized to receive treatment with (1 mg/kg on alternate days for 30 days; n=51), liposomal (2 per day 5 or complex n=51). Infusion-associated reactions frequent and persistent in subjects treated deoxycholate. The illness 3 failed respond treatment, experienced relapse. Final cure...
<ns4:p><ns4:bold>Background:</ns4:bold> The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), took more lives than combined epidemics of SARS, MERS, H1N1, and Ebola. Currently, the prevention control spread are goals in COVID-19 management as there no specific drugs to cure or vaccines available for prevention. Hence, drug repurposing was explored many research groups, target proteins have been examined. major protease...
The importance of the main protease (Mpro) enzyme SARS-CoV-2 in digestion viral polyproteins introduces Mpro as an attractive drug target for antiviral design. This study aims to carry out molecular docking, dynamics studies, and prediction ADMET properties selected potential molecules. provides insight into biomolecular interactions understand inhibitory mechanism spatial orientation tested ligands further, identification key amino acid residues within substrate-binding pocket that can be...
Abstract: The expression “as sure as night follows a day” emulates those certain cycles in the environment that are always stable. Circadian rhythms group of processes occur within body synchronisation with external factors 24 h cycle. Changes lifestyle and work shifts have disrupted these stable rhythms, which is leading cause diseases. Associations between biological clocks diseases abundant. However, it also known drugs more efficiently minimum toxicity when given during particular phase...
Purpose: The current study aims the lymphatic delivery of leflunomide loaded nanostructured lipid carriers (LNLC) for treatment rheumatoid arthritis, mainly focussed to enhance via chylomicron formation, improved bioavailability and reduced systemic toxicity. Methods: Melt emulsification ultra-sonication method was used formulate carrier (NLC) containing leflunomide. Four batches were prepared by using various concentration surfactants (tween 80 poloxmer 188) mixtures (stearic acid oleic...
The coronavirus disease (COVID-19) is a pandemic that started in the City of Wuhan, Hubei Province, China, caused by spread (SARS-CoV-2). Drug discovery teams around globe are race to develop medicine for its management. It takes time novel molecule enter market, and ideal way exploit already approved drugs repurpose them therapeutically. We have attempted screen selected molecules with an affinity towards multiple protein targets COVID-19 using Schrödinger suit silico predictions. proteins...
Any person who intends to travel outdoor must be prepared deal with all sorts of weather, starting from the dry hot condition chilled coolness. The extremities both conditions can lead serious health problems. Changes in single degree affect body's biochemistry leading various abnormalities. There is a limitation which layers clothing piled onto our body as well taking steps betray ourselves extreme weather. An appropriate solution weather introduced. With touch button, user control...
Abstract The human Abl kinases comprise a family of proteins that are known to be key stimulus drivers in the signaling pathways modulating cell growth, survival, adhesion, and apoptosis. Recent collative studies have indicated role activation Abl-related genes solid tumors; further terming as molecular switches which promote proliferation, tumorigenesis, metastasis. up-regulated Abl-kinase expression colorectal cancer (CRC) tyrosine kinase activity Matrigel invasion CRC cells cemented its...
Objective: Formulation and characterization of clobetasol propionate (CP) pramoxine hydrochloride (PH) loaded nanostructured lipid carriers (NLC) offering improved performance in terms drug loading long-term stability for topical delivery.
 Methods: Drug-loaded NLC formulation was designed by melt-emulsification ultrasonication technique, fluctuating the concentration stearic acid oleic acid. Poloxamer F68 tween 80 were used as surfactants soya lecithin stabilizer co-surfactant....
Background: SARS coronavirus-2 (SARS-CoV-2) infection causes Novel Coronavirus Disease (COVID-19). It is a respiratory tract and currently becoming pandemic worldwideaffecting more than 50 lakh people. As of now, there no treatment or vaccine developed for disease management. The main protease, Mpro in SARS-CoV-2 druggable target explored by many scientists. We targeted this with the well-known approach drug repurposing using computational tools. Methods: Schrödinger software was used study....
Assessing dental anxiety as a predictor of the likely behavior child in operatory is paramount importance for clinician to render quality care.This study aims correlate preschool children shown during doll placement test with that their behavioral patterns first visit.This cross-sectional was conducted between ages 3-7 years.During visit, background variables were elicited from parent/guardian at reception desk. Later play area, given set dolls representing dentist, child, and mother place...
Leaf spot in mulberry leaves affects the silk production significantly by reducing nutritive quality of leaves. The leaf disease can be caused diversified pathogens irrespective localities same climatic region. Under present investigation approximately 84% incidence has been recorded Karnataka as per survey conducted at farmer well germplasm locations. diversification causing agent observed including some new candidates such Bipolaris sorokiniana, Curvularia lunata, Cladosporium...