A5009751565- Organometallic Compounds Synthesis and Characterization
- Cholinesterase and Neurodegenerative Diseases
- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Image Processing and 3D Reconstruction
- Crystal structures of chemical compounds
- Handwritten Text Recognition Techniques
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Medicinal Plants and Neuroprotection
- Livestock Management and Performance Improvement
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Organometallic Complex Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- Genetic and phenotypic traits in livestock
- AI-based Problem Solving and Planning
- Software Engineering Techniques and Practices
- Dental Research and COVID-19
- Synthesis and Biological Evaluation
- COVID-19 diagnosis using AI
- Synthesis and Reactivity of Heterocycles
- Analytical Chemistry and Chromatography
- Synthesis and characterization of novel inorganic/organometallic compounds
- Multiple Sclerosis Research Studies
Chandigarh University
2022-2025
Banaras Hindu University
2018-2024
Indian Veterinary Research Institute
2000-2024
Virginia Commonwealth University
2023-2024
National Institute of Technology Hamirpur
2024
Institute of Management Technology
2024
University of Maryland, Baltimore
2023
Dar Al Uloom University
2021
Rhodes College
2021
Indian Institute of Technology Indore
1965-2020
The importance of the main protease (Mpro) enzyme SARS-CoV-2 in digestion viral polyproteins introduces Mpro as an attractive drug target for antiviral design. This study aims to carry out molecular docking, dynamics studies, and prediction ADMET properties selected potential molecules. provides insight into biomolecular interactions understand inhibitory mechanism spatial orientation tested ligands further, identification key amino acid residues within substrate-binding pocket that can be...
Alzheimer's disease (AD) is one of the most familiar multifactorial and complex neurodegenerative disorders characterized by loss cholinergic neurons in brain. The various attempts for drug development to treat AD have been hampered largely unsuccessful clinical trials last two decades. Developing a new from scratch takes enormous amounts time, effort money, mainly due several barriers therapeutic process. Drug repurposing strategy resuscitates this slow discovery process finding uses...
Abstract Alzheimer's disease (AD) is a common age‐related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Although there currently no successful pharmacotherapy for AD, researchers are continuously exploring various pathogenesis of AD to develop potential therapeutic drugs. Of multiple hypotheses cholinergic amyloid‐β (Aβ) hypothesis main targeting AD. Some proposed that symptoms involved (loss memory, impairment, amnesia) event...
Abstract: Resilient Apache Glue Jobs: Mitigating 404 and 429 Errors with Proactive Strategies This research paper examines incident management strategies for Jobs, specifically focusing on mitigating the impact of frequent Not Found Too Many Requests errors.Byanalyzing root causes these errors, such as data inconsistencies, network issues, resource limitations, we propose a framework proactive management. leverages combination techniques, including development comprehensive list error...
Abstract: Typically, large-scale data transfers into the database cause lots of locking which negatively affects query execution, concurrency, as well blocking operations such ALTER, UPDATE, and DELETE. To ensure consistency, a set locks are necessary, that can become performance bottleneck deadlocks. The contributions this paper include three novel techniques to improve operation defeat large loads through lock contention. We minimize handling efficiency by converting lists sets first....
Alzheimer's disease (AD) is the most prevalent cause of dementia and characterized by low levels acetyl butyrylcholine, increased oxidative stress, inflammation, accumulation metals, aggregations Aβ tau proteins. Current treatments for AD provide only symptomatic relief without impacting pathological hallmarks disease. In our ongoing efforts to develop naturally inspired novel multitarget molecules AD, through extensive medicinal chemistry efforts, we have developed 13a, harboring key...
The pathological hallmarks of Alzheimer's disease (AD) are manifested as an increase in the level oxidative stress and aggregation amyloid-β protein. In vitro, vivo, silico experiments were designed carried out with multifunctional cholinergic inhibitor, F24 (EJMC-7a) to explore its neuroprotective effects AD models. neuroprotection ability was tested SH-SY5Y cells, a widely used neuronal cell line. pretreatment subsequent co-treatment cells different doses effective rescuing from H2O2...
In this study, the miRNAome and proteome of virulent Peste des petits ruminants virus (PPRV) infected goat peripheral blood mononuclear cells (PBMCs) were analyzed. The identified differentially expressed miRNAs (DEmiRNAs) found to govern genes that modulate immune response based on data. top ten significantly enriched processes be governed by 98 genes. DEmiRNAs governing these number them. Out 10 DEmiRNAs, 7 upregulated 3 downregulated. These include miR-664, miR-2311, miR-2897, miR-484,...
Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout lifetime an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) most group inherited diseases that mainly affect children. Pathological features NCLs include accumulation lysosomal storage material, neuroinflammation, and degeneration, yet exact cause this remains poorly understood....
In 2019, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began infecting humans, resulting in the COVID-19 pandemic. While push for development of vaccines has yielded some positive results, emergence additional variants led to concerns surrounding sustained vaccine effectiveness as become dominant strains. This work was undertaken develop peptide-based antivirals capable targeting both wildtype (WT) heptad repeat 1 (HR1) domain SARS-CoV-2 and new HR1 which have developed....
This paper aims that analysing neural network method in pattern recognition. A is a processing device, whose design was inspired by the and functioning of human brain their components. The proposed solutions focus on applying Hamming Network MAXNET model for primary function which to retrieve stored memory, when an incomplete or noisy version presented. An associative memory storehouse associated patterns are encoded some form. In auto-association, input with itself states output units...