A5041368809- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Animal Disease Management and Epidemiology
- Livestock and Poultry Management
- Cancer-related molecular mechanisms research
- Livestock Management and Performance Improvement
- Virology and Viral Diseases
- Silkworms and Sericulture Research
- Livestock Farming and Management
- Animal Virus Infections Studies
- Animal Genetics and Reproduction
- Viral Infections and Vectors
- Microbial infections and disease research
- interferon and immune responses
- Animal Nutrition and Physiology
- Immune Response and Inflammation
- Virus-based gene therapy research
- Agricultural Systems and Practices
- Agricultural Economics and Practices
- vaccines and immunoinformatics approaches
- Poxvirus research and outbreaks
- Vector-Borne Animal Diseases
- Molecular Biology Techniques and Applications
- Animal Diversity and Health Studies
National Bureau of Animal Genetic Resources
2009-2023
Indian Veterinary Research Institute
2014-2023
Biological E (India)
2016-2022
Indian Council of Agricultural Research
2020-2022
The recently constructed river buffalo whole-genome radiation hybrid panel (BBURH5000) has already been used to generate preliminary (RH) maps for several chromosomes, and buffalo-bovine comparative chromosome have constructed. Here, we present the first-generation whole genome RH map (WG-RH) of generated from cattle-derived markers. aligned bovine sequence assembly Btau_4.0, providing valuable mapping information both species. A total 3990 markers were typed on BBURH5000 panel, which 3072...
Summary The aim of the present study was to assess genetic variation and establish relationship amongst three Indian zebu cattle breeds using 20 bovine‐specific microsatellite markers. A total 136 unrelated DNA samples from Sahiwal (SC), Hariana (HC) Deoni (DC) were genotyped estimate within between breed diversity indices. estimated mean allelic 5.2, 6.5 5.9 in SC, HC DC, respectively, with a 167 alleles. average observed expected heterozygosity for population varied 0.42 (SC) 0.59 (DC),...
The water buffalo (Bubalus bubalis) is an important dairy animal on the Indian subcontinent and in Southeast Asian countries. diversity differentiation among 12 populations or breeds of were studied. Data generated analyzed from 527 animals belonging to 10 recognized 2 additional by using 22 microsatellite loci. Relationships estimated based genetic distances. Bayesian analysis grouped into 8 distinctive clusters. Geographically close clustered together, except for Jaffarabadi Murrah, which...
Peste des petits ruminants (PPR), is an acute transboundary viral disease of economic importance, affecting goats and sheep. Mass vaccination programs around the world resulted in decline PPR outbreaks. Sungri 96 a live attenuated vaccine, widely used Northern India against PPR. This vaccine virus, isolated from goat works efficiently both sheep goat. Global gene expression changes under virus infection are not yet well defined. Therefore, this study we investigated host-vaccine interactions...
Knowledge about genetic diversity is very essential for the management and sustainable utilization of livestock resources. In this study, we presented a comprehensive genome-wide analysis diversity, ROH, inbreeding, linkage disequilibrium, effective population size haplotype block structure in Tharparkar cattle India. A total 24 animals used study were genotyped with Illumina BovineSNP50 array. After quality control, 22,825 biallelic SNPs retained, which HWE, MAF > 0.05 genotyping rate >90%....
Vrindavani is an Indian composite cattle breed developed by crossbreeding taurine dairy breeds with native indicine cattle. The constituent were selected for higher milk production and adaptation to the tropical climate. However, selection response traits in genome not explored. In this study, we provide first overview of signatures genome. A total 96 genotyped using BovineSNP50 BeadChip SNP genotype data its collected from a public database. Within-breed investigated integrated haplotype...
Copy number variations (CNVs) are major forms of genetic variation with an increasing importance in animal genomics. This study used the Illumina BovineSNP 50 K BeadChip to detect genome-wide CNVs Tharparkar cattle. With aid PennCNV software, we noticed a total 447 copy regions (CNVRs) across autosomal genome, occupying nearly 2.17% bovine genome. The average size detected CNVRs was found be 122.2 kb, smallest CNVR being 50.02 kb size, largest 1,232.87 Kb. Enrichment analyses genes these...
Indian cattle (Bos indicus) and riverine buffalo (Bubalus bubalis) give a poor yield of milk but it has high fat protein percentage compared to taurine cattle. The identification QTLs (Quantitative Trait Loci) on BTA14 BTA6 its subsequent fine mapping led two non conservative mutations affecting production composition. Our objective was estimate the frequency K232A (DGAT1--diacylglycerol-acyltransferase 1) Y581S (ABCG2--ATP binding cassette sub family G member 2) polymorphisms in diverse...
Estimation of genetic variability and relationship among different livestock breeds is important for management resources their sustainable utilization conservation. This more when the species, like camel, have shown a sharp decline in head count during last decade. In present study we estimated four camel India using 23 microsatellite loci. A total 252 alleles were observed across all populations with mean number per locus as 8.04, 7.30, 6.39, 7.43 Bikaneri, Jaisalmeri, Kutchi, Mewari...
Summary The present study aimed at assessing the status of Chilika buffalo population eastern India employing cytogenetic and molecular markers. buffaloes investigated cytogenetically possess a somatic chromosome count 50, identical to that typical riverine buffaloes. Various diversity estimates, viz. observed number alleles (4.68), effective (2.79), (0.487) expected (0.602) heterozygosity across 25 heterologous microsatellite markers indicated presence moderate level genetic in buffaloes,...
This study analysed buffaloes from north-east India and compared their nuclear mitochondrial DNA variations with of mainland India, China, Mediterranean South-East Asia. Microsatellite genotypes 338 including 210 six Indian buffalo populations three breeds were to evaluate genetic structure evolutionary relationships. Phylogenetic analysis multidimensional scaling plot pairwise FST revealed the clustering all swamp-type Lower Assamese (significantly hybrid type) in one plane river another...
In this study, the miRNAome and proteome of virulent Peste des petits ruminants virus (PPRV) infected goat peripheral blood mononuclear cells (PBMCs) were analyzed. The identified differentially expressed miRNAs (DEmiRNAs) found to govern genes that modulate immune response based on data. top ten significantly enriched processes be governed by 98 genes. DEmiRNAs governing these number them. Out 10 DEmiRNAs, 7 upregulated 3 downregulated. These include miR-664, miR-2311, miR-2897, miR-484,...
In this study, transcriptome analysis of PPRV infected PBMCs subsets - T helper cells, cytotoxic monocytes and B lymphocytes was done to delineate their role in host response. found infect not monocytes. The established receptor for PPRV-SLAM downregulated non-dysregulated A profound deviation the global gene expression profile with a large number unique upregulated genes (893) (799) observed comparison lymphocytes. ISGs ISG15, Mx1, Mx2, RSAD2, IFIT3, IFIT5 that play antiviral response viral...
Abstract Identification of suitable candidate reference genes is an important prerequisite for validating the gene expression data obtained from downstream analysis RNA sequencing using quantitative real time PCR (qRT-PCR). Though existence a universal myth, commonly used can be assessed stability to confer their suitability as in studies. In this study, we evaluated ten most ( GAPDH , ACTB HSP90 HMBS 18S rRNA B2M POLR2A HPRT1 ACAC YWHAZ ) fourteen different Peste des petits ruminants virus...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral pathogen causing life-threatening diseases in humans. Interaction between the spike protein of SARS-CoV-2 and angiotensin-converting enzyme (ACE2) potential factor infectivity host. In this study, interaction with its receptor, ACE2, different hosts was evaluated to predict probability entry. Phylogeny alignment comparison ACE2 sequences did not lead any meaningful conclusion on entry hosts. The binding ability assessed...
Elucidation of genetic variability and relationship among breeds has direct relevance with the issues sustainable use domestic animal resources. In present study, polymorphism was evaluated using 22 microsatellite loci in unrelated samples Red Kandhari Deoni cattle inhabiting same geographical area Marathwada region Maharashtra state (western India). This work mainly aimed at assessing current diversity to understand whether two zebu populations question are genetically differentiated. A...
Three buffalo populations viz.Bhadawari, Tarai and local buffaloes of Kerala were genotyped using 24 heterologous polymorphic microsatellite loci.A total 140 alleles observed with an average heterozygosity 0.63.All the loci neutral 18 out in Hardy Weinberg Equilibrium.The F IS values (estimate inbreeding) for 16 all three negative.This indicated lack population structure populations.The effective number immigrants was 5.88 per generation between Bhadawari which quite high suggesting...