A5002125677- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Inhalation and Respiratory Drug Delivery
- Pharmacological Effects of Natural Compounds
- Phytochemical compounds biological activities
- Psidium guajava Extracts and Applications
- Transgenic Plants and Applications
- Multicomponent Synthesis of Heterocycles
- Nanoparticle-Based Drug Delivery
- Allergic Rhinitis and Sensitization
- Ethnobotanical and Medicinal Plants Studies
- Coconut Research and Applications
- Synthesis and biological activity
- Phytochemistry Medicinal Plant Applications
- Pediatric health and respiratory diseases
- Hydrogels: synthesis, properties, applications
- Phytochemistry and Biological Activities
- Rheumatoid Arthritis Research and Therapies
Amrita Vishwa Vidyapeetham
2013-2024
Amrita Institute of Medical Sciences and Research Centre
2018-2023
Aims Community College
2011-2015
Vinayaka Missions University
2012
Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease that causes disability due to progressive inflammation and destruction of the tissues around joints. Methotrexate mainly used prevent progression joint reduce deformity. The major challenge in treating RA with methotrexate systemic side effects limit dose escalation. Hence, novel formulation methotrexate-loaded nanoemulsion for subcutaneous administration was developed aims deliver into system via lymph. prepared by using...
Nanotechnology has transformed engineering designs across a wide spectrum of materials and applications. Mesoporous Silica Nanoparticles (MSNs) are one the new fabrications nanostructures as medication delivery systems. MSNs have pore sizes varying from 2 to 50 nm, making them ideal for variety biological They offer unique characteristics such tunable surface area, well-defined properties, ability improve drug pharmacokinetic characteristics. Moreover, they potential reduce adverse effects...
Samadera indica Gaetrn (Simaroubaceae) is claimed to possess various pharmacological activities like antioxidant, antifungal, antitumor, antiviral, and so on, but its taste bitter. The aim of the present study investigate toxicity methanolic extract develop suitable herbal formulations indica, having efficient antimicrobial activity. prepared from dried leaves by continuous hot percolation, were used examine toxicity, according OECD 423 guidelines, in Swiss Albino mice. Topical incorporating...
Purpose: The current study aims the lymphatic delivery of leflunomide loaded nanostructured lipid carriers (LNLC) for treatment rheumatoid arthritis, mainly focussed to enhance via chylomicron formation, improved bioavailability and reduced systemic toxicity. Methods: Melt emulsification ultra-sonication method was used formulate carrier (NLC) containing leflunomide. Four batches were prepared by using various concentration surfactants (tween 80 poloxmer 188) mixtures (stearic acid oleic...
Introduction: Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal economical implications. The relatively lower incidence adverse reactions to plant preparations compared modern pharmaceuticals is encouraging consuming public national health care institutions consider medicines as alternatives synthetic [1, 2, 3, 4] . Various crude extracts Mirabilis jalapa Linn family Nyctaginaceae has been widely used in traditional medicine....
Antioxidant has gained importance in the current scenario as it an ability to trap free radicals which are produced during degenerative diseases. Natural antioxidant is considered superior synthetic safe and produces a prominent action. Samadera indica bitter plant widely distributed throughout India, mostly found evergreen forest of Western Ghats along river shore, bitterness due presence flavanoids like Quassinoids. Literatures showed Quassinoids therefore, may show activity not yet ruled...
Allergen immunotherapy (AIT) involves the regimen of gradually incrementing doses allergen, thereby inducing desensitization and tolerance. Sublingual Immunotherapy tablets (SLIT-tablets) have been formulated for several allergies had manifested efficacy allergic rhinitis asthma. SLIT promises an alternative method to other routes AIT enabling patients self-administer AIT.
Objective: Formulation and characterization of clobetasol propionate (CP) pramoxine hydrochloride (PH) loaded nanostructured lipid carriers (NLC) offering improved performance in terms drug loading long-term stability for topical delivery.
 Methods: Drug-loaded NLC formulation was designed by melt-emulsification ultrasonication technique, fluctuating the concentration stearic acid oleic acid. Poloxamer F68 tween 80 were used as surfactants soya lecithin stabilizer co-surfactant....
ABSTRACTObjective: The current research deals with the formulation and evaluation of synthesized quinazolinone derivative for colon site specific delivery.Methods: was enteric coated 5% Eudragit L-100 by wet granulation method using guar gum, pectin,and gum pectin combination as hydrophilic polymer. prepared matrix tablet characterized differential scanning calorimetry andevaluated different pre-compression post-compression studies drug release profiles.Results: All tablets were within range...
Nonalcoholic Palm Nectar from Cocos nucifera (NPNC), a bio-refresher obtained the juvenile inflorescence of coconut palm; is prominent as nutritional health drink. The aim this study was to investigate and medicinal properties NPNC its products; sugar (NPNCS) honey (NPNCH). collected samples were subjected physicochemical evaluations such pH, Titrable Acidity, Total Soluble Solids, Ash value, using standard techniques. analysis revealed suitability natural drink over conventionally available...
The target of the study was development and in vitro characterisation an effective ethosomal formulation clotrimazole to performance investigated under different preparation conditions. EE from 9 formulations, optimisation done on basis its results which considering concentration lecithin ethanol as two factors release their responses. optimization F6 gained a very good drug highest entrapment efficiency 93.203%. permeation flux were obtained order MLVs > ESUVs SSUVs LUVs. This gives idea...
Objective: To formulate and evaluate an extended-release (ER) tablet of a new molecule, 2-amino-4-(4-bromophenyl)-7-hydroxy-4H-chromene-3- carbonitrile using combination two polymers (hydroxypropyl methyl cellulose [HPMC] K100 HPMC phthalate) which control the rate degree drug release through 12 hrs period protect from acidic pH.Methods: Five batches tablets (4HC1, 4HC2, 4HC3, 4HC4, 4HC5) were produced by direct compression method. Morphological evaluation powder blend was carried out...
Objective: Metformin is an oral antidiabetic drug in the biguanide class. It first-line of choice for treatment type 2 diabetes. The objective present study was to retard release metformin using carrier erythrocyte getting a parenteral slow depot formulation.Methods: retards by encapsulating carier erythrocyte. Endocytosis method used encapsulation metormin.Results: optimized formulation shows 98.34% within 12 days. From invitro data zero order kinetic graph best fit graph. % cell recovered...