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Katherine McGrath

ORCID: 0000-0001-8201-0234
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About
Contact & Profiles
A5068558727
Research Areas
  • Cancer-related gene regulation
  • RNA modifications and cancer
  • Epigenetics and DNA Methylation
  • Erythrocyte Function and Pathophysiology
  • CRISPR and Genetic Engineering
  • Autophagy in Disease and Therapy
  • Zebrafish Biomedical Research Applications
  • Peptidase Inhibition and Analysis
  • Eicosanoids and Hypertension Pharmacology
  • Atherosclerosis and Cardiovascular Diseases
  • Fatty Acid Research and Health

Boston Children's Hospital
 2014-2020

Harvard Stem Cell Institute
 2020

Dana-Farber Cancer Institute
 2013-2020

Boston Children's Museum
 2014

Harvard University
 2014

 Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors
OPENALEX - Publications 
Sergei Doulatov Linda T. Vo Elizabeth R. Macari Lara Wahlster Melissa A. Kinney and 18 more Alison M. Taylor Jessica Barragan Manav Gupta Katherine McGrath Hsiang‐Ying Lee Jessica M. Humphries Alexander L. DeVine Anupama Narla Blanche P. Alter Alan H. Beggs Suneet Agarwal Benjamin L. Ebert Hanna T. Gazda Harvey F. Lodish Colin A. Sieff Thorsten M. Schlaeger Leonard I. Zon George Q. Daley

A stem cell reprogramming approach enables disease modeling and drug discovery for a genetic blood disorder uncovers candidate therapeutic.

10.1126/scitranslmed.aah5645 article EN Science Translational Medicine 2017-02-08
 Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families
OPENALEX - Publications 
Kari G. Rabe Elizabeth R. Macari Lea Jessop Steven R. Ellis Timothy A. Myers and 13 more Neelam Giri Alison M. Taylor Katherine McGrath Jessica M. Humphries Bari J. Ballew Meredith Yeager Joseph F. Boland Ji He Belynda Hicks Laurie Burdett Blanche P. Alter Leonard I. Zon Sharon A. Savage

10.1182/blood-2013-11-540278 article EN Blood 2014-05-15
 Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia
OPENALEX - Publications 
Alison M. Taylor Elizabeth R. Macari Iris T. Chan Megan C. Blair Sergei Doulatov and 18 more Linda T. Vo David M. Raiser Kavitha Siva Anindita Basak Mehdi Pirouz Arish N Shah Katherine McGrath Jessica M. Humphries Emma Stillman Blanche P. Alter Eliezer Calo Richard I. Gregory Vijay G. Sankaran Johan Flygare Benjamin L. Ebert Yi Zhou George Q. Daley Leonard I. Zon

Calmodulin inhibitors rescue erythropoiesis and p53-dependent phenotypes of Diamond-Blackfan anemia.

10.1126/scitranslmed.abb5831 article EN Science Translational Medicine 2020-10-21
 Calmodulin Inhibition Rescues DBA Models with Ribosomal Protein Deficiency through Reduction of RSK Signaling
OPENALEX - Publications 
Elizabeth R. Macari Alison M. Taylor David M. Raiser Kavitha Siva Katherine McGrath and 4 more Jessica M. Humphries Johan Flygare Benjamin L. Ebert Leonard I. Zon

10.1182/blood.v128.22.332.332 article EN Blood 2016-12-02
 Modeling Diamond Blackfan Anemia in Vivo Using Human Induced Pluripotent Stem Cells
OPENALEX - Publications 
Sergei Doulatov Linda T. Vo Elizabeth R. Macari Stephanie Chou Manav Gupta and 5 more Michelle Godfrey Katherine McGrath Thorsten M. Schlaeger Leonard I. Zon George Q. Daley

10.1182/blood.v124.21.359.359 article EN Blood 2014-12-06
 Drug discovery using induced pluripotent stem cells identifies autophagy as a therapeutic pathway for anemia
OPENALEX - Publications 
Sergei Doulatov Linda T. Vo Elizabeth R. Macari Lara Wahlster Alison M. Taylor and 12 more Manav Gupta Katherine McGrath Anupama Narla Blanche P. Alter Hanna T. Gazda Colin A. Sieff Suneet Agrawal Alan H. Beggs Benjamin L. Ebert Thorsten M. Schlaeger Leonard I. Zon George Q. Daley

10.1016/j.exphem.2016.06.063 article EN publisher-specific-oa Experimental Hematology 2016-08-24
 Engineering hematopoietic stem and progenitor cells from human pluripotent stem cells for modeling congenital anemias
OPENALEX - Publications 
Linda T. Vo Sergei Doulatov Elizabeth R. Macari Stephanie Chou Manav Gupta and 5 more Michelle Godfrey Katherine McGrath Thorsten M. Schlaeger Leonard I. Zon George Q. Daley

10.1016/j.exphem.2014.07.051 article EN Experimental Hematology 2014-08-01
 Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency in in Vitro and In Vivo Diamond Blackfan Anemia Models
OPENALEX - Publications 
Elizabeth R. Macari Alison M. Taylor David M. Raiser Kavitha Siva Katherine McGrath and 4 more Jessica M. Humphries Johan Flygare Benjamin L. Ebert Leonard I. Zon

10.1182/blood.v126.23.672.672 article EN Blood 2015-12-03
 Functional Consequences Of RPS29 Germline Mutations In Diamond-Blackfan Anemia
OPENALEX - Publications 
Kari G. Rabe Elizabeth R. Macari Lea Jessop Timothy A. Myers Neelam Giri and 12 more Alison M. Taylor Katherine McGrath Jessica M. Humphries Bari J. Ballew Meredith Yeager Joseph F. Boland Ji He Belynda Hicks Laurie Burdett Blanche P. Alter Leonard I. Zon Sharon A. Savage

10.1182/blood.v122.21.2465.2465 article EN Blood 2013-11-15
 Abstract: 1066 HIGH DENSITY LIPOPROTEINS (HDLS) INDUCE A MILD OXIDATIVE STRESS RESPONSE IN HUMAN ENDOTHELIAL CELLS THAT INCREASES CELLULAR ANTIOXIDANT PROTEIN EXPRESSION AND PROTECTS AGAINST INFLAMMATORY INSULT
OPENALEX - Publications 
Adam Heather XH Li Katherine McGrath K.-A. Rye P Barter

10.1016/s1567-5688(09)70407-6 article EN Atherosclerosis Supplements 2009-06-01
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