Abstract The effect of substituting sodium for calcium on enhanced osteoconductivity hydroxyapatite was newly investigated. Sodium‐substituted synthesized by reacting hydroxide and phosphoric acid with nitrate followed sintering. As a control, pure prepared under identical conditions, but without the addition nitrate. Substitution in produced structural vacancies carbonate ion from phosphate site hydrogen after total system energy sodium‐substituted defects calculated ab initio methods based...

Abstract Owing to enhanced biocompatibility and osseointegration, hydroxyapatite (HAp) coatings are often applied biomedical devices that implanted directly on the bone. Although various HAp coating techniques have been developed, they restricted due time‐consuming synthesis additional processes. Herein, development of a rapid single‐step method for simultaneous via nanosecond laser surface treatment is described. In conventional HAp‐coating method, resulting interface between layer base...

Abstract Prompt and robust bone regeneration has been clinically achieved using supraphysiological doses of morphogenetic protein‐2 (BMP‐2) to overcome the short half‐life rapid clearance. However, uncontrolled burst release exogenous BMP‐2 causes severe complications such as heterotopic ossification soft tissue inflammation. Therefore, numerous researches have focused on developing a new delivery system for sustained profile by immobilizing in various polymeric vehicles. Herein, avoid...

Hydroxyapatite, an essential mineral in human bones composed mainly of calcium and phosphorus, is widely used to coat bone graft implant surfaces for enhanced biocompatibility formation. For a strong implant–bone bond, the bone-forming cells must not only adhere surface but also move requiring However, adhesion tends inhibit cell migration on hydroxyapatite. Herein, highway pattern that can promote was prepared using nanosecond laser hydroxyapatite coating. The developed promoted movement...

During the past decade, there has been extensive research toward possibility of exploring magnesium and its alloys as biocompatible biodegradable materials for implantable applications. Its practical medical application, however, limited to specific areas owing rapid corrosion in initial stage consequent complications. Surface coatings can significantly reduce Mg alloys, several studies have carried out improve adhesion strength coating surfaces alloys. The composition hydroxyapatite (HAp)...

Lasers that exhibit monochromaticity, directionality, coherence, and focusability have been used in health care defense industries for over five decades. Recently, the application of lasers medical biomedical devices has increased significantly. Considering materials are attached to skin or implanted into body, immune response, inflammation control, cell adhesion, migration, biocompatibility device must be investigated. Therefore, researchers actively studying laser processing technology...

Abstract This study aimed to develop a simulation model that accounts for skin-specific properties in order predict photothermal damage during skin laser treatment. To construct computational model, surface geometry information was obtained from an optical coherence tomography image, and the absorption coefficient of determined through spectrophotometry. The distribution internal light dose inside medium calculated using propagation based on Monte Carlo method. response due modeled by finite...

Abstract A novel anorganic bovine bone xenograft with enhanced bioactivity and osteoconductivity was prepared by an ion substitution method using sodium hypochlorite. Bovine granules were defatted, washed, then soaked in hypochlorite solution at room temperature. Subsequently, the dried heat‐treated 1000°C As a control, same conditions but without treatment. Phase, functional group, elemental analyses XRD, FTIR, EPMA showed that pure hydroxyapatite sodium‐chlorine‐bearing hydroxyapatite,...

Mg has received much attention as a next-generation implantable material owing to its biocompatibility, bone-like mechanical properties, and biodegradability in physiological environments. The application of various polymer coatings been conducted the past reduce rapid formation hydrogen gas local change pH during initial phase chemical reaction with body fluids. Here, we propose femtosecond (fs) laser-mediated surface patterning for significant enhancement binding strength coating material,...

Synthetic biomaterials are used to overcome the limited quantity of human-derived and impart additional biofunctionality. Although numerous synthetic processes have been developed using various phases methods, currently commonly some issues, such as a long process time difficulties with extensive size control high-concentration metal ion substitution achieve functionality. Herein, we introduce rapid synthesis method laser-induced hydrothermal process. Based on thermal interaction between...

Polyetheretherketone (PEEK), a bioinert polymer known for its mechanical properties similar to bone, is capable of averting stress shielding. Due these attributes, it finds applications in diverse fields like orthopedics, encompassing cervical disc replacement the neck and spine, along with dentistry plastic surgery. However, due insufficient bonding various methods such as hydroxyapatite (HA) coating on surface are attempted. Nonetheless, interface between ceramic, two different materials,...

Abstract A new method to deliver fluoride using biodegradable poly(lactic‐ co ‐glycolic acid) microcapsules suppress cariogenic bacterial growth during orthodontic treatment was investigated. coaxial ultrasonic atomizer used encapsulate KF solution into microcapsules. The adhesive resin disk containing loaded (DFLM) prepared by LED light curing. microstructure of microcapsules, successful loading KF, fracture strength, and shear bonding strength were assessed FE‐SEM, confocal laser scanning...

Abstract A modified mineral‐trioxide‐aggregate (mMTA) with rapid setting capacity was newly synthesized by spray‐pyrolysis following a sol–gel reaction. Its faster and initially higher compressive strength compared Portland cement (PC) were evaluated. The precursor solution of the mMTA prepared through condensation hydrolysis among Ca(NO 3 ) 2 ·4H O, Si(OC H 5 4 , Al(NO ·9H O under nitric acid. powder then at 1500°C. particle shape spherical an average size 0.8 ± 0.3 μm, while PC particles...

Abstract The capacity of hydroxyl ions when used as a nucleating agent to form apatite in simulated body fluid (SBF) was investigated. A 25 wt% poly(ϵ-caprolactone) solution prepared using 1,1,3,3-hexafluoro-2-propanol solvent and electrospun under an electric field 1 kV/cm. Subsequently, non-woven fabrics were dipped into 4 M NaOH the experimental group then directly air-dried (NaOH coated), while control washed with deionized water treated) ambient conditions. that coated treated exposed...

The effect of grain size dental zirconia on the shear bond strength composite resin cement was newly studied. Disc-shaped with small (sample S) and large L) grains were made by sintering pre-sintered at 1450°C for 0.5 h 40 h, respectively. After sintering, average sample S 1.37 ± 0.15 µm, while that L 3.74 0.50 µm. sintered discs successively polished different grades diamond alumina slurries. interfacial free energies 63.5 4.2 dyne/cm 52.1 5.5 L. Stainless steel cylinders, previously...

<TEX>$^1H-^{15}N$</TEX> heteronuclear dipolar coupling solid-state NMR experiments on lipid bilayer or bicelle samples are very useful for the structural studies of membrane proteins. However, to study these biological using NMR, a specific probe with high efficiency and capability is required. In this paper, we describe optimized design, construction, 400 MHz wide-bore 5-mm solenoidal rf coil power, multi-pulse sequence experiments, such as 2D PISEMA SAMMY.

The effect of grain size hydroxyapatite on its osteoconductivity was newly investigated. discs, which had small (specimen S) and large L), were prepared through microwave sintering at 1100°C for 6 720 min, respectively. average specimen S about 15 times smaller than that L. surface energy 1.6 higher L under the same roughness. For test, porous granules using PEG porogen. superior to four weeks after implantation in calvarial defects New Zealand white rabbits. Taken together, it can be...

Cells in the human body experience different growth environments and conditions, such as compressive pressure oxygen concentrations, depending on type location of tissue. Thus, a culture device that emulates environment inside is required to study cells outside body.A blanket-type cell (Direct Contact Pressing: DCP) was fabricated with an alginate-based hydrogel. Changes morphology due DCP were observed using phase contrast microscope. The changes permeability according hydrogel...

Event Abstract Back to Preparation of an MTA through spray-pyrolysis Sumin Lim1, Jeong-Cheol Lee1, Seung-Hoon Um1 and Sanghoon Rhee1 1 Seoul National University, Dental Biomaterials Science, Korea The method coupled with a sol-gel reaction was newly applied synthesize homogeneous small powder because it provides relatively easy way control stoichiometry, can achieve high purity, is highly reproducible, good candidate for mass production via continuous process. After the synthesis powder, its...

Bone Regeneration In article number 2200416, Hojeong Jeon, Justin J. Chung, and co-workers fabricate complex coacervate of fucoidan poly-l-lysine to prevent bone morphogenetic protein-2 (BMP-2) leakage from collagen sponges. The microencapsulation ability the significantly enhances BMP-2 bioactivity provides protection against antagonist proteolysis. Moreover, containing allows regeneration precisely within defect site.

Abstract Background: Cells in the human body experience different growth environments and conditions, such as pressure oxygen concentrations, depending on type location of tissue. For this reason, a culture device that emulates environment inside to study cells outside is required. Method: A blanket-type cell (Direct Contact Pressing: DCP) was fabricated with an alginate-based hydrogel. Changes morphology due DCP were observed phase-contrast microscope. The modification permeability...