A5059113679- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- semigroups and automata theory
- Computability, Logic, AI Algorithms
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- stochastic dynamics and bifurcation
- Advanced Chemical Sensor Technologies
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Cell Image Analysis Techniques
- Advanced Neuroimaging Techniques and Applications
- Organ Donation and Transplantation
- Photonic and Optical Devices
- Advanced MEMS and NEMS Technologies
- Advanced Memory and Neural Computing
- Topological and Geometric Data Analysis
KTH Royal Institute of Technology
2018-2024
Science for Life Laboratory
2020-2024
The basal ganglia play an important role in decision making and selection of action primarily based on input from cortex, thalamus, the dopamine system. Their main structure, striatum, is central to this process. It consists two types projection neurons, together representing 95% 5% interneurons, among which are cholinergic, fast-spiking, low threshold-spiking subtypes. membrane properties, soma-dendritic shape, intrastriatal extrastriatal synaptic interactions these neurons quite well...
Abstract The striatum is the main input stage of basal ganglia receiving extrinsic from cortex and thalamus. striatal projection neurons (SPN) constitute 95% in mice while remaining 5% are cholinergic GABAergic interneurons. (ChIN) low‐threshold spiking interneurons (LTS) spontaneously active form a subnetwork involved salience detection goal‐directed learning. Activation ChINs has been shown to inhibit LTS via muscarinic receptor type 4 (M4R) turn can modulate nitric oxide (NO) causing...
Plateau potentials are a critical feature of neuronal excitability, but their all-or-none behavior is not easily captured in modeling. In this study, we investigated models plateau multi-compartment neuron and found that including glutamate spillover provides robust behavior. This result arises due to the prolonged duration extrasynaptic glutamate. When included, very sensitive steepness Mg 2+ block. These results suggest potentially significant role potential generation, providing mechanism...
Abstract Computational models of ion channels represent the building blocks conductance-based, biologically inspired neurons and neural networks. Ion are still widely modelled by means formalism developed seminal work Hodgkin Huxley (HH), although electrophysiological features currently known to be better fitted kinetic Markov-type models. The present study is aimed at showing why simplified more suitable for modelling as compared HH ones, how a manual optimization process can rationally...
The basal ganglia are important for action initiation, selection, and motor learning. input level, the striatum, receives preferentially from cortex thalamus is to 95% composed of striatal projection neurons (SPNs) with sparse GABAergic collaterals targeting distal dendrites neighboring SPNs, in a distance-dependent manner. remaining 5% cholinergic interneurons. Our aim here investigate role surround inhibition intrinsic function striatum. Large-scale networks 20 40 thousand were simulated...
The majority of excitatory synapses in the brain uses glutamate as neurotransmitter, and synaptic transmission is primarily mediated by AMPA NMDA receptors postsynaptic neurons. Here, we present data-driven models currents these mouse striatum. It common to fit two decay time constants phases current profiles but then compute a single weighted mean constant describe them. We have shown that this approach does not lead an improvement fitting, and, hence, new model based on use both fast slow...
Abstract Striatum, the input stage of basal ganglia, is important for sensory-motor integration, initiation and selection behavior, as well reward learning. Striatum receives glutamatergic inputs from mainly cortex thalamus. In rodents, striatal projection neurons (SPNs), giving rise to direct indirect pathway (dSPNs iSPNs, respectively), account 95% neurons, remaining 5% are GABAergic cholinergic interneurons. Interneuron axon terminals local dSPN iSPN collaterals form an intricate network....
ABSTRACT Striatum, the input stage of basal ganglia, is important for sensory-motor integration, initiation and selection behaviour, as well reward learning. Striatum receives glutamatergic inputs from mainly cortex thalamus. In rodents, striatal projection neurons (SPNs), giving rise to direct indirect pathway (dSPNs iSPNs, respectively), account 95% remaining 5% are GABAergic cholinergic interneurons. Interneuron axon terminals local dSPN iSPN collaterals form an intricate network....
Plateau potentials are a critical feature of neuronal excitability, but their all-or-none behavior is not easily captured in modeling. In this study, we investigated models plateau multi-compartment neuron and found that including glutamate spillover provides robust behavior. When included, the very sensitive to steepness Mg block. These results suggest potentially significant role potential generation, providing mechanism for across wide range slopes block curve. We also illustrate...
Simulating large-scale networks of neurons is an important approach both when interpreting and synthesising experimental data from healthy diseased brains. Here we focus on the striatum, main input stage largest nucleus basal ganglia. The ganglia are involved in motor learning, action-selection reinforcement learning. Dysfunction these areas lead to a variety brain disorders such as Parkinson’s disease (PD), neurodegenerative disorder that affects nerve cells. We presented nearly full-scale...
In Italy, to show the willingness donate one's organs, there is principle of explicit consensus (or disagreement) (Law n. 91 01.04.1999, Art. 23; Decree Italian Health Ministry 08.04.2000). According data Association for donation tissues and cells (AIDO), in 2017 Campania Region (Southern Italy) an average 12.5 people x1,000,000 donated their organs vs. a national 23.7. This negative discrepancy between regional highlights that it imperative promote awareness-raising measures address...
Abstract Background Computational models of ionic channels represent the building blocks conductance-based, biologically inspired neurons and neural networks. Ionic are still widely modelled by means formalism developed seminal work Hodgkin Huxley, although electrophysiological features currently known to be better fitted kinetic (Markov-type) models. Objective The present study is aimed at showing why kinetic, simplified suited model compared Huxley models, how manual optimization process...
The relationship between the structure and network dynamics within striatum is currently not well understood. We have applied algebraic topology to investigate local structural connectivity in striatum, then used simulations predict how shapes dynamics. a full-scale digital reconstruction of mouse striatal microcircuitry: both healthy at different stages Parkinson’s Disease (PD). These are characterized by successively modified morphologies projection neurons (SPN), including changes...