A5062605787- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Cancer Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Phytochemical compounds biological activities
- Genetic Neurodegenerative Diseases
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Synthesis and bioactivity of alkaloids
- MicroRNA in disease regulation
- Metabolism and Genetic Disorders
- Bacterial Genetics and Biotechnology
- Lipid Membrane Structure and Behavior
- Synthesis and Biological Evaluation
University of British Columbia
2021-2023
Austrian Academy of Sciences
2020
Institute of Molecular Biotechnology
2020
École Polytechnique Fédérale de Lausanne
2015
Article23 August 2021Open Access Transparent process Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites David Hoffmann IMBA, Institute Molecular Biotechnology the Austrian Academy Sciences, Vienna, Austria These authors contributed equally to this work Search more papers by author Stefan Mereiter orcid.org/0000-0002-4832-3090 Yoo Jin Oh orcid.org/0000-0002-9636-3329 Biophysics, Johannes Kepler University Linz, Vanessa Monteil orcid.org/0000-0002-2652-5695...
Abstract Protein-based affinity reagents (like antibodies or alternative binding scaffolds) offer wide-ranging applications for basic research and therapeutic approaches. However, whereas small chemical molecules efficiently reach intracellular targets, the delivery of macromolecules into cytosol cells remains a major challenge; thus cytosolic protein-based are rather limited. Some pathogenic bacteria have evolved conserved type III secretion system (T3SS) which allows effector proteins...
Abstract Dopa-responsive dystonia (DRD) and Parkinson’s disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways biomarkers for guiding therapies is crucial due to debilitating nature these disorders. Recent genetic studies have identified variants GTP cyclohydrolase-1 (GCH1), rate-limiting enzyme in tetrahydrobiopterin (BH4) synthesis, as causative Here, we show that pharmacological inhibition BH4 synthesis mice...
Abstract New SARS-CoV-2 variants are continuously emerging with critical implications for therapies or vaccinations. All 22 N-glycan sites of Spike remain highly conserved among the B.1.1.7, 501Y.V2 and P.1, opening an avenue robust therapeutic intervention. Here we used a comprehensive library mammalian carbohydrate-binding proteins (lectins) to probe sugar residues on full-length trimeric receptor binding domain (RBD) SARS-CoV-2. Two lectins, Clec4g CD209c, were identified strongly bind...