A5032457652- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Diet and metabolism studies
- Carcinogens and Genotoxicity Assessment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- DNA Repair Mechanisms
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Anesthesia and Pain Management
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Anorectal Disease Treatments and Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Stoma care and complications
- Nausea and vomiting management
- DNA and Nucleic Acid Chemistry
- Pelvic and Acetabular Injuries
- Electrolyte and hormonal disorders
- Clinical Nutrition and Gastroenterology
- Muscle Physiology and Disorders
- COVID-19 and healthcare impacts
Ersta sjukhus
2014-2025
Karolinska Institutet
2015-2025
Finnish Safety and Chemicals Agency
2021
European Chemicals Agency
2021
Mayo Clinic
2001-2019
University of Manitoba
2019
The University of Texas MD Anderson Cancer Center
2019
Virginia Commonwealth University
2019
University of Calgary
2019
Dana-Farber Brigham Cancer Center
2019
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic production and increasing disposal in skeletal muscle; however, the molecular site of metformin action not well understood. AMP-activated protein kinase (AMPK) activity increases response to depletion cellular energy stores, this enzyme has been implicated stimulation uptake into muscle inhibition liver gluconeogenesis. We recently reported AMPK activated cultured rat hepatocytes,...
<h3>Background</h3> This is the first updated Enhanced Recovery After Surgery (ERAS) Society guideline presenting a consensus for optimal perioperative care in gynecologic/oncology surgery. <h3>Methods</h3> A database search of publications using Embase and PubMed was performed. Studies on each item within ERAS protocol were selected with emphasis meta-analyses, randomized controlled trials, large prospective cohort studies. These studies then reviewed graded according to Grading...
Abstract Background Single-centre studies have suggested that enhanced recovery can be achieved with multimodal perioperative care protocols. This international observational study evaluated the implementation of an programme in five European centres and examined determinants affecting length hospital stay. Methods Four hundred twenty-five consecutive patients undergoing elective open colorectal resection above peritoneal reflection between January 2001 2004 were enrolled a protocol defined...
We studied the effects of different preoperative oral fluid protocols on discomfort, residual gastric volumes, and acidity. Two-hundred-fifty-two elective abdominal surgery patients (ASA physical status I–II) were randomized to preparation with a 12.5% carbohydrate drink (CHO), placebo (flavored water), or overnight fasting. The CHO Placebo groups double-blinded given 800 mL evening before 400 morning surgery. Visual analog scales used score 11 discomfort variables. did not increase volumes...
Postoperative insulin resistance is a well-characterized metabolic state that has been shown to correlate with the length of postoperative stay in hospital. Preoperative intravenous or oral carbohydrate treatment attenuate development measured 1 day after surgery. To study effects preoperative on changes and substrate utilization, absence confounding factors, 15 patients were double-blindly treated either carbohydrate-rich beverage (12.5%) ( n = 8) placebo 7) before undergoing total hip...
Abstract Background A carbohydrate-rich drink (CHO) has been shown to reduce preoperative discomfort. It was hypothesized that it may also postoperative nausea and vomiting (PONV). Methods Patients undergoing elective laparoscopic cholecystectomy under inhalational anaesthesia (127 women 45 men; mean(s.d.) 48(15) years) were randomized either fasting, intake of CHO (50 kcal/100 ml, 290 mOsm/kg) or placebo. The non-fasting groups double-blinded; patients ingested 800 ml liquid on the evening...
on behalf of the Enhanced Recovery After Surgery (ERAS) Group Evidence for optimal perioperative care in colorectal surgery is abundant.By avoiding fasting, intravenous fluid overload, and activation neuroendocrine stress response, postoperative catabolism reduced recovery enhanced.The specific measures that can be used routinely include no bowel preparation, epidural anaesthesia/analgesia continued one to two days postoperatively, nasogastric decompression tube fluid/saline restriction,...
Background Overnight fasting is routine before elective surgery. This may not be the optimal way to prepare for surgical stress, however, because intravenous carbohydrate supplementation instead of has recently been shown reduce postoperative insulin resistance. In current study, gastric emptying a carbohydrate-rich drink was investigated surgery and in control situation. Methods Twelve patients scheduled were randomly given 400 mL either (285 mOsm/kg, 12.0% carbohydrates, n = 6) or water 4...
Abstract Background Preoperative oral carbohydrate (CHO) reduces postoperative insulin resistance. In this randomized trial, the effect of CHO on whole-body protein turnover was studied. Methods Glucose and kinetics ([6,62H2]D-glucose, [2H5]phenylalanine, [2H2]tyrosine [2H4]tyrosine) substrate oxidation (indirect calorimetry) were studied at baseline during hyperinsulinaemic normoglycaemic clamping before first day after colorectal resection. Fifteen patients to receive a preoperative...
Abstract Background The effects of immediate postoperative enteral nutrition on nitrogen balance and insulin resistance were studied in patients subjected to an enhanced-recovery protocol. Methods Eighteen undergoing major colorectal surgery protocol randomized feeding for 4 days with either complete or hypocaloric nutrition. Nitrogen changes glucose kinetics, substrate utilization (indirect calorimetry) sensitivity (hyperinsulinaemic–euglycaemic clamp) measured. Values are mean(s.e.m.)....
Abstract Background Hyperglycaemia following major surgery increases morbidity, but may be improved by use of enhanced-recovery protocols. It is not known whether preoperative haemoglobin (Hb) A1c could predict hyperglycaemia and/or adverse outcome after colorectal surgery. Methods Some 120 patients without diabetes underwent within an protocol. HbA1c was measured at admission and 4 weeks All received oral diet beginning h operation. Plasma glucose monitored five times daily. Patients were...
Background: Post‐operative insulin resistance and hyperglycaemia are associated with an impaired outcome after surgery. Pre‐operative oral carbohydrate loading (CHO) reduces post‐operative a reduced risk of during nutrition. Insulin‐resistant diabetic patients have not been given CHO because the effects on pre‐operative glycaemia gastric emptying unknown. Methods: Twenty‐five (45–73 years) type 2 diabetes [glycated haemoglobin (HbA1c) 6.2 ± 0.2%, mean SEM] 10 healthy control subjects (45–72...