A5003858015- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Veterinary Medicine and Surgery
- Adrenal Hormones and Disorders
- Thyroid Disorders and Treatments
- Veterinary Oncology Research
- Diabetes and associated disorders
- Herpesvirus Infections and Treatments
- Retinoids in leukemia and cellular processes
- Fibroblast Growth Factor Research
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Virus-based gene therapy research
- Reproductive Physiology in Livestock
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Sexual Differentiation and Disorders
- Diet and metabolism studies
- HIV Research and Treatment
- Animal health and immunology
- Rabies epidemiology and control
- Hypothalamic control of reproductive hormones
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
University of Buenos Aires
2012-2023
Universidad Católica de Córdoba
2023
Universitat Pompeu Fabra
2020
Indiana University – Purdue University Indianapolis
2014-2016
Indiana University Health
2014-2016
Fundación Cardiovascular de Colombia
2016
Universidade Federal de São Paulo
2014
Instituto de Genética Veterinaria
2012
Hospital de Clínicas "José de San Martín"
2008
Fundación Ciencias Exactas y Naturales
2006
Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation rodent models, we have studied its action dogs with disease. A randomized treatment (n = 22) vs. ketoconazole 20) was assigned for a period of 180 d. Clinical signs, plasma ACTH α-MSH, the cortisol/creatinine urine ratio, magnetic resonance imaging...
SOM230 (pasireotide) is a multiligand somatostatin (SRIF) analog able to bind receptor (SSTR) subtypes 1, 2, 3 and 5, trigger antisecretory antiproliferative signaling cascades. Canines have become in vivo models test the pharmacological treatment of corticotropinomas because they frequently develop Cushing’s disease spontaneous manner, due adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. Different levels expression SSTR2 SSTR5 been shown both mouse AtT20 cells canine tumoral...
Honokiol, a biologically active compound isolated from Magnolia bark, has been shown to possess promising anticancer effect through induction of apoptosis. However, there is relative lack information regarding its anti‑metastatic activity. Renal cell carcinoma (RCC) the most common malignancy adult kidney and known for high risk metastasis. Clinically, therapeutic methods metastatic RCC cases are limited efforts exploit new treatments still ongoing. The results our current investigation...
The aim of this study was to evaluate the efficacy antiretrovirals: Zidovudine (ZDV) alone; ZDV + Recombinant Human Interferon-α (rHuIFN-α); Lamivudine (3TC) and valproic acid (Valp) on naturally feline immunodeficiency virus (FIV)-infected cats, in late phase asymptomatic stage infection. follow-up performed over one year, through clinical evaluation determination viral loads CD4+/CD8+ ratios. Neurological signs were studied by visual auditory evoked potentials (VEP, AEP) responses abnormal...
For the conclusive diagnosis of Cushing's Syndrome, a stimulating ACTH test or low suppressive Dexamethasone is used. Reports in other species than dog indicate that plasma cortisol concentration after administration affected by gender. We investigated effect gender on response to and tests dogs.Seven healthy adult Cocker Spaniels (4 females 3 males) were assigned two factorial design: 4 dogs (2 2 received IV 0.01 mg/kg, while an saline solution (control group). Two weeks later treatments...
Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia, dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production the skeletal muscle adipose tissue. The aim this study was to evaluate effects metformin on control metabolic disorders dogs hyperadrenocorticism (HAC). Twenty-three HAC were randomly divided into two groups, consisting group (10 mg metformin/kg/12 h). Both groups received same treatment for HAC. At...
Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine (NET) are characterised synthesis peptides with hormone activity. A dog clinical diagnosis Cushing's syndrome and presenting abdominal tumour located area left adrenal gland was sent to hospital. Cortisol not inhibited at four eight hours after application low-dose dexamethasone cortisol/creatinine ratio elevated (93 × 10-6,...
Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of female Rottweiler with bilateral was described. Clinical manifestations muscle weakness, polydipsia, polyuria, diarrhea weight loss were observed. Two adrenal neoplasms identified incidentally ultrasonography, tumor left lobe palpation. Primary hyperparathyroidism diagnosed biochemical...
The objective of the present study was to compare effects isotretinoin 9-cis (RA9-cis) as a post-surgery treatment thyroid carcinoma traditional (doxorubicin) and no treatment. Owners who did not want their dogs receive were placed into control group A (GA; n=10). remaining randomly either B (GB; n=12) received doxorubicin at dose 30 mg/m2 every three weeks, for six complete cycles or C (GC; n=15) treated with RA9-cis 2 mg/kg/day 6 months. time recurrence significantly shorter in GA GB...
Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal's life. Among these effects, hypertension renal damage can be mentioned. A group 20 dogs with pituitary dependent hyperadrenocorticism (PDH) 12 control were used to study following parameters: nitric oxide (NO nit/nit) concentrations, diastolic systolic blood pressure, artery resistance index by...